Alan Cheng

US Patent:

20130111931, May 9, 2013

Filed:

Apr 27, 2012

Appl. No.:

13/457879

Inventors:

Nigel J. Grinter - Buffalo Grove IL, US
Alan T. Cheng - Naperville IL, US
Ying Zhou - Naperville IL, US

International Classification:

F25D 13/00
F25D 3/10

US Classification:

62 62, 62440

Abstract:

A method and system for controlled rate freezing and nucleation of biological materials is provided. The presently disclosed system and method provides the ability to rapidly cool the materials contained in vials or other containers within a cooling unit via forced convective cooling and optionally simultaneous pressure drop using uniform and unidirectional flow of cryogen in proximity to the plurality of vials disposed within a cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as well as the chamber pressure as a function of time.

US Patent:

20230111536, Apr 13, 2023

Filed:

Sep 21, 2022

Appl. No.:

17/933950

Inventors:

- Manalapan FL, US
Alan Cheng - Redwood City CA, US
Ryan Powell - Sunnyvale CA, US
Jennifer Teng - San Francisco CA, US

International Classification:

A61N 1/36
A61N 1/05
A61B 17/34
A61N 1/372

Abstract:

One aspect of the present disclosure includes a delivery tool configured to deliver a neurostimulator into a pterygopalatine fossa of a subject. The neurostimulator can include a body connected to an integral stimulation lead having one or more stimulating electrodes. The delivery tool can comprise a handle, an elongated shaft extending from the handle, a hub portion, and a double barrel sheath. The hub portion can be located between the shaft and a spine member that extends axially away from the hub portion. The hub portion can be sized and dimensioned to releasably mate with the neurostimulator. The double barrel sheath can be connected to the spine member. A central lumen can extend through at least a portion of the shaft and the hub portion. The central lumen can be adapted to receive a lead ejector for selective deployment of the stimulation lead from the double barrel sheath.

US Patent:

20200197697, Jun 25, 2020

Filed:

Jan 7, 2020

Appl. No.:

16/736004

Inventors:

- Redwood City CA, US
Alan Cheng - Redwood City CA, US
Ryan Powell - Sunnyvale CA, US
Jennifer Teng - San Francisco CA, US

International Classification:

A61N 1/36
A61N 1/372
A61N 1/05
A61B 17/34

Abstract:

One aspect of the present disclosure includes a delivery tool configured to deliver a neurostimulator into a pterygopalatine fossa of a subject. The neurostimulator can include a body connected to an integral stimulation lead having one or more stimulating electrodes. The delivery tool can comprise a handle, an elongated shaft extending from the handle, a hub portion, and a double barrel sheath. The hub portion can be located between the shaft and a spine member that extends axially away from the hub portion. The hub portion can be sized and dimensioned to releasably mate with the neurostimulator. The double barrel sheath can be connected to the spine member. A central lumen can extend through at least a portion of the shaft and the hub portion. The central lumen can be adapted to receive a lead ejector for selective deployment of the stimulation lead from the double barrel sheath.

US Patent:

20190300507, Oct 3, 2019

Filed:

Nov 3, 2017

Appl. No.:

16/347970

Inventors:

- Thousand Oaks CA, US
Alan C. CHENG - San Francisco CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Paul John DRANSFIELD - Arlington MA, US
James S. HARVEY - Arlington MA, US
Jonathan HOUZE - Cambridge MA, US
Aarif Yusuf KHAKOO - Woodside CA, US
Su-Jen LAI - Cambridge MA, US
Zhihua MA - Lexington MA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Charles KREIMAN - Hopkinton MA, US
David C. MOEBIUS - Westwood MA, US
Ankit SHARMA - Quincy MA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 405/14
C07D 417/14
C07D 413/14
A61P 9/04

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, I or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.

US Patent:

20180319773, Nov 8, 2018

Filed:

Jul 12, 2018

Appl. No.:

16/033632

Inventors:

- Thousand Oaks CA, US
Xiaoqi CHEN - Palo Alto CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Jeffrey DEIGNAN - San Francisco CA, US
Paul John DRANSFIELD - Arlington MA, US
Xiaohui DU - Belmont CA, US
Zice FU - Foster City CA, US
Julie Anne HEATH - Chico CA, US
Daniel B. HORNE - Natick MA, US
Jonathan HOUZE - Cambridge MA, US
Matthew R. KALLER - Ventura CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Washington DC, US
Su-Jen LAI - Boston MA, US
Zhihua MA - Lexington MA, US
Lawrence R. MCGEE - Pacifica CA, US
Julio C. MEDINA - San Carlos CA, US
Jeffrey T. MIHALIC - San Francisco CA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Kevin YANG - San Gabriel CA, US
Wen-Chen YEH - Belmont CA, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Robert P. FARRELL - Thousand Oaks CA, US
Simon J. HEDLEY - Thousand Oaks CA, US
Ted C. JUDD - Granada Hills CA, US
Frank KAYSER - San Francisco CA, US

Assignee:

AMGEN INC. - Thousand Oaks CA

International Classification:

C07D 401/14
C07D 401/12
A61K 31/437
C07D 417/14
A61K 45/06
C07B 57/00
C07B 59/00
C07D 211/54
C07D 213/71
C07D 213/82
C07D 239/26
C07D 239/30
C07D 241/12
C07D 241/24
C07D 249/08
C07D 471/04
C07D 413/14
C07D 413/04
C07D 401/04
C07D 213/61
C07D 239/34
C07D 241/18
C07F 7/08
C07D 295/16
C07C 311/13
A61K 31/695
A61K 31/4439
A61K 31/444
A61K 31/497
A61K 31/501
A61K 31/506
A61K 31/513
C07D 405/14

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.

US Patent:

20180222895, Aug 9, 2018

Filed:

Apr 5, 2018

Appl. No.:

15/945852

Inventors:

- Thousand Oaks CA, US
Alan C. Cheng - San Francisco CA, US
Richard V. Connors - Mesa AZ, US
Mikkel V. Debenedetto - Waltham MA, US
Paul John Dransfield - Arlington MA, US
Zice Fu - Foster City CA, US
James S. Harvey - Brookline MA, US
Julie Anne Heath - Chico CA, US
Jonathan Houze - Cambridge MA, US
Ted C. Judd - Granada Hills CA, US
David John Kopecky - Washington DC, US
Su-Jen Lai - Boston MA, US
Zhihua Ma - Lexington MA, US
Nobuko Nishimura - West Hills CA, US
Steven H. Olson - Millbrae CA, US
Vatee Pattaropong - Bedford MA, US
Xiaodong Wang - Johns Creek GA, US

International Classification:

C07D 405/14
C07D 409/14
C07D 403/14
C07D 403/04
C07D 401/14
A61K 45/06
A61K 31/4439
A61K 31/437
A61K 31/506
A61K 31/5383
C07D 498/04
C07D 405/04
C07D 471/04
A61K 31/497

Abstract:

Compounds of Formula V, salts thereof, tautomers thereof, and salts of the tautomers have the following structure and are useful compounds in preparing small molecule agonists of the APJ Receptor:where the definitions of the variables are provided herein.

US Patent:

20170320860, Nov 9, 2017

Filed:

May 2, 2017

Appl. No.:

15/584109

Inventors:

- Thousand Oaks CA, US
Yinhong CHEN - Hayward CA, US
Alan C. CHENG - San Francisco CA, US
Richard V. CONNORS - Mesa AZ, US
Mikkel V. DEBENEDETTO - Waltham MA, US
Paul John DRANSFIELD - Arlington MA, US
Zice FU - Foster City CA, US
James S. HARVEY - Brookline MA, US
Julie Anne HEATH - Chico CA, US
Simon J. HEDLEY - Thousand Oaks CA, US
Jonathan HOUZE - Cambridge MA, US
Ted C. JUDD - Granada Hills CA, US
Aarif Yusuf KHAKOO - Woodside CA, US
David John KOPECKY - Studio City CA, US
Su-Jen LAI - Boston MA, US
Zhihua MA - Lexington MA, US
Nobuko NISHIMURA - West Hills CA, US
Steven H. OLSON - Millbrae CA, US
Vatee PATTAROPONG - Bedford MA, US
Gayathri SWAMINATH - Brisbane CA, US
Xiaodong WANG - Johns Creek GA, US
Wen-Chen YEH - Belmont CA, US

International Classification:

C07D 405/14
C07D 471/04
C07D 405/04
A61K 31/5383
A61K 31/437
A61K 31/506
A61K 31/497
A61K 31/4439
C07D 498/04
A61K 45/06

Abstract:

Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures:where the definitions of the variables are provided herein.

US Patent:

20170165482, Jun 15, 2017

Filed:

Dec 9, 2016

Appl. No.:

15/373698

Inventors:

- Redwood City CA, US
Alan Cheng - Redwood City CA, US
Ryan Powell - Sunnyvale CA, US
Jennifer Teng - San Francisco CA, US

International Classification:

A61N 1/36
A61N 1/372
A61N 1/05

Abstract:

One aspect of the present disclosure includes a delivery tool configured to deliver a neurostimulator into a pterygopalatine fossa of a subject. The neurostimulator can include a body connected to an integral stimulation lead having one or more stimulating electrodes. The delivery tool can comprise a handle, an elongated shaft extending from the handle, a hub portion, and a double barrel sheath. The hub portion can be located between the shaft and a spine member that extends axially away from the hub portion. The hub portion can be sized and dimensioned to releasably mate with the neurostimulator. The double barrel sheath can be connected to the spine member. A central lumen can extend through at least a portion of the shaft and the hub portion. The central lumen can be adapted to receive a lead ejector for selective deployment of the stimulation lead from the double barrel sheath.