Alan F Gasiecki

US Patent:

6506876, Jan 14, 2003

Filed:

Oct 11, 1994

Appl. No.:

08/321184

Inventors:

Nizal Samuel Chandrakumar - Vernon Hills IL
Barbara Baosheng Chen - Glenview IL
Michael Clare - Skokie IL
Bipinchandra Nanubhai Desai - Vernon Hills IL
Stevan Wakefield Djuric - Malvern PA
Stephen Hermann Docter - Mt. Prospect IL
Alan Frank Gasiecki - Vernon Hills IL
Richard Arthur Haack - Chicago IL
Julie Marion Miyashiro - Chicago IL
Thomas Dale Penning - Elmhurst IL
Mark Andrew Russell - Gurnee IL
Stella Siu-tzyy Yu - Morton Grove IL

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A01N 4340

US Classification:

530330, 514317, 546225

Abstract:

The present invention provides compounds of the formula Ar âQâAr âYâRâZ and pharmaceutically acceptable salts thereof wherein Ar and Ar are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB production, such as psoriasis, ulcerative colitis, IBD and asthma.

US Patent:

6531494, Mar 11, 2003

Filed:

Aug 29, 2001

Appl. No.:

09/942214

Inventors:

Ish Kumar Khanna - Libertyville IL
Yi Yu - Glenview IL
Balekudru Devadas - Chesterfield MO
Nizal S Chandrakumar - Vernon Hills IL
Renee M. Huff - Park Ridge IL
Bipinchandra N. Desai - Vernon Hills IL
Srinivasan Raj Nagarajan - Chesterfield MO
Alan F. Gasiecki - Vernon Hills IL
Thomas D. Penning - Elmhurst IL
Mark A. Russell - Gurnee IL
Mark L. Boys - Mt. Prospect IL
Lori A. Schretzman - Gurnee IL
Barbara B. Chen - Glenview IL
Thomas Rogers - Ballwin MO
John Adam Wendt - Libertyville IL
Albert Khilevich - Buffalo Grove IL
Yaping Wang - Naperville IL

Assignee:

Pharmacia Corporation - Peapack NJ

International Classification:

A61K 3144

US Classification:

514352, 546312, 546194, 514318

Abstract:

The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the and/or the integrin.

US Patent:

6677308, Jan 13, 2004

Filed:

Aug 28, 1998

Appl. No.:

09/141547

Inventors:

Nizal Chandrakumar - Vernon Hills IL
Michael Clare - Skokie IL
Wendell Doubleday - Encinitas CA
Alan F. Gasiecki - Vernon Hills IL
Mark A. Russell - Gurnee IL

Assignee:

G. D. Searle Co. - Chicago IL

International Classification:

A61K 3800

US Classification:

514 19, 514476

Abstract:

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the integrin.

US Patent:

6689754, Feb 10, 2004

Filed:

Apr 8, 1999

Appl. No.:

09/289140

Inventors:

Nizal Samuel Chandrakumar - Vernon Hills IL
Bipinchandra Nanubhai Desai - Vernon Hills IL
Balekudru Devadas - Chesterfield MO
Alan Frank Gasiecki - Vernon Hills IL
Renee Huff - Park Ridge IL
Ish K. Khanna - Vernon Hills IL
James W. Malecha - Libertyville IL
Julie M. Miyashiro - Skokie IL
Shashidhar N. Rao - Mundelein IL
Joseph Gerace Rico - Ballwin MO
Thomas Edward Rogers - Ballwin MO
Peter Gerrard Ruminski - Dardenne Prairie MO
Mark Andrew Russell - Gurnee IL
Yi Yu - Skokie IL

Assignee:

G. D. Searle Co. - Chicago IL

International Classification:

C07K 506

US Classification:

514 20, 514 19, 546304

Abstract:

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and methods of treating conditions mediated by the integrin.

US Patent:

6900232, May 31, 2005

Filed:

Jun 15, 2001

Appl. No.:

09/882186

Inventors:

Ish Kumar Khanna - Libertyville IL, US
Michael Clare - Skokie IL, US
Alan F. Gasiecki - Vernon Hills IL, US
Thomas Rogers - Ballwin MO, US
Barbara Chen - Northbrook IL, US
Mark Russell - Gurnee IL, US

Assignee:

Pharmacia Corporation - Peapack NJ

International Classification:

A61K031/44
C07D213/72

US Classification:

514352, 546312, 546194, 546318

Abstract:

The present invention relates to a class of compounds represented by the Formula I Wherein Ais a pyridinyl of the formula optionally substituted by one or more Rselected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αβand/or αβintegrin.

US Patent:

6921767, Jul 26, 2005

Filed:

Dec 20, 2002

Appl. No.:

10/326299

Inventors:

Nagarajan R. Srinivasan - Chesterfield MO, US
Ish Kumar Khanna - Libertyville IL, US
Michael Clare - Skokie IL, US
Alan Gasiecki - Vernon Hills IL, US
Thomas Rogers - Ballwin MO, US
Barbara Chen - Glenview IL, US
Mark Russell - Gurnee IL, US
Yu Yi - Skokie IL, US
Renee M. Huff - Park Ridge IL, US
Bipinchandra N. Desai - Vernon Hills IL, US
Balekudru Devadas - Chesterfield MO, US
Mihir D. Parikh - Chesterfield MO, US
Thomas Penning - Elmhurst IL, US

Assignee:

Pharmacia Corporation - Chesterfield MO

International Classification:

C07D239/14
A61K031/505
A61P019/10
A61P009/10

US Classification:

514269, 514275, 544332, 544298, 544318

Abstract:

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αβand/or αβintegrin.

US Patent:

6949578, Sep 27, 2005

Filed:

Jul 14, 2004

Appl. No.:

10/891361

Inventors:

Ish Kumar Khanna - Libertyville IL, US
Michael Clare - Skokie IL, US
Alan F. Gasiecki - Vernon Hills IL, US
Thomas Rogers - Ballwin MO, US
Barbara Chen - Northbrook IL, US
Mark Russell - Gurnee IL, US

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

C07D231/38
C07D233/38
A61K031/415
A61K031/4172

US Classification:

514397, 5483111, 5483164, 5483315, 5483265, 5483401, 5483411, 5483641, 5483714, 5483717, 5483721, 5483751, 5483761, 514398, 514399, 514406, 514407

Abstract:

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αβand/or αβintegrin.

US Patent:

7119203, Oct 10, 2006

Filed:

Apr 25, 2003

Appl. No.:

10/618288

Inventors:

Thomas E. Barta - Evanston IL, US
Daniel P. Becker - Glenview IL, US
Louis J. Bedell - Mt. Prospect IL, US
Terri L. Boehm - Ballwin MO, US
David L. Brown - Chesterfield MO, US
Jeffery N. Carroll - Columbia IL, US
Yiyuan Chen - Skokie IL, US
Yvette M. Fobian - Wildwood MO, US
John N. Freskos - Clayton MO, US
Alan F. Gasiecki - Vernon Hills IL, US
Margaret L. Grapperhaus - Troy IL, US
Robert M. Heintz - Ballwin MO, US
Susan L. Hockerman - Lincolnwood IL, US
Darren J. Kassab - O'Fallon MO, US
Ish K. Khanna - Libertyville IL, US
Stephen A. Kolodziej - Ballwin MO, US
Mark A. Massa - Ballwin MO, US
Joseph J. McDonald - Wildwood MO, US
Brent V. Mischke - Defiance MO, US
Deborah A. Mischke - Defiance MO, US
Patrick B. Mullins - St. Louis MO, US
Mark A. Nagy - Chesterfield MO, US
Monica B. Norton - St. Louis MO, US
Joseph G. Rico - Ballwin MO, US
Michelle A. Schmidt - Belleville IL, US
Nathan W. Stehle - Grafton WI, US
John J. Talley - Cambridge MA, US
William F. Vernier - St. Louis MO, US
Clara I. Villamil - Glenview IL, US
Lijuan J. Wang - Wildwood MO, US
Thomas A. Wynn - Chicago IL, US

Assignee:

Pharmacia Corporation - St. Louis MO

International Classification:

C07D 405/14
C07D 405/12
A61K 31/496

US Classification:

544364, 544130, 544238, 544295, 544357, 544360, 544336, 544366, 544367, 544369, 544374, 544383, 544408, 546187, 546193, 546194, 546207, 546210, 546212, 546214, 546233, 5142355, 51425202, 51425203, 51425211, 51425218, 51425309, 51425312, 51425311, 5142541, 51425405, 51425502, 51425505, 51425403, 514314, 514316, 514318, 514323, 514326, 514327, 51425503

Abstract:

This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula:.