Alan K Mallams

US Patent:

6358968, Mar 19, 2002

Filed:

Jan 14, 2000

Appl. No.:

09/484375

Inventors:

Stacy W. Remiszewski - Washington Township, Bergen County NJ
Alan K. Mallams - Hackettstown NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514290, 546 93

Abstract:

Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

US Patent:

6362188, Mar 26, 2002

Filed:

Dec 16, 1999

Appl. No.:

09/465523

Inventors:

Timothy Guzi - Chatham NJ
Dinanath F. Rane - Morganville NJ
Alan K. Mallams - Hackettstown NJ
Alan B. Cooper - West Caldwell NJ
Ronald J. Doll - Maplewood NJ
Viyyoor M. Girijavallabhan - Parsippany NJ
Arthur G. Taveras - Denville NJ
Corey Strickland - North Plainfield NJ
Joseph M. Kelly - Parlin NJ
Jianping Chao - Summit NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31496

US Classification:

51425302, 51421705, 5142282, 5142328, 514218, 540544, 540598, 540575, 544 60, 544121, 544361, 544370, 544360

Abstract:

Disclosed are compounds of the formula: wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

US Patent:

6365588, Apr 2, 2002

Filed:

Jul 9, 1999

Appl. No.:

09/350870

Inventors:

Robert W. Bishop - Pompton Plains NJ
Ronald J. Doll - Maplewood NJ
Alan K. Mallams - Long Valley NJ
F. George Njoroge - Union NJ
Joanne M. Petrin - Cedar Grove NJ
John J. Piwinski - Clinton Township NJ
Ronald L. Wolin - Westfield NJ
Arthur G. Taveras - Rockaway NJ
Stacy W. Remiszewski - Washington Township NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 3154

US Classification:

5142282, 514253, 514254, 514290, 544 582, 544361, 546 93

Abstract:

A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1. 0: to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of the formulas 5. 0, 5. 1 and 5. 2, wherein R is âC(R )(R )(R ), and 5. 3, 5. 3A and 5. 3B, wherein R is âN(R )(R ), are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5. 0, 5. 1, 5. 2 and 5. 3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5. 0, 5. 1, 5. 2 and 5. 3.

US Patent:

6492381, Dec 10, 2002

Filed:

May 16, 2000

Appl. No.:

09/571922

Inventors:

W. Robert Bishop - Pompton Plains NJ
Ronald J. Doll - Maplewood NJ
Alan K. Mallams - Long Valley NJ
F. George Njoroge - Union NJ
Joanne M. Petrin - Cedar Grove NJ
John J. Piwinski - Clinton Township NJ
Ronald L. Wolin - Westfield NJ
Arthur G. Taveras - Rockaway NJ
Stacy W. Remiszewski - Township of Wasington NJ

Assignee:

Schering Corp. - Kenilworth NJ

International Classification:

A61K 31435

US Classification:

514290, 546 93

Abstract:

A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1. 0 Also disclosed are novel compounds of the formulas: and Also disclosed are processes for making 3-substituted compounds of the Formulas 1. 1, 1. 2 and 1. 3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1. 1, 1. 2, and 1. 3.

US Patent:

6576639, Jun 10, 2003

Filed:

Mar 8, 2000

Appl. No.:

09/520449

Inventors:

Ronald J. Doll - Maplewood NJ
Joseph M. Kelly - Parlin NJ
Alan K. Mallams - Hackettstown NJ
F. George Njoroge - Union NJ
Stacy W. Remiszewski - Washington Township NJ
Arthur G. Taveras - Rockaway NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 3144

US Classification:

514290, 546 93, 544361

Abstract:

Novel compounds, such as: are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds.

US Patent:

6699872, Mar 2, 2004

Filed:

Nov 1, 2001

Appl. No.:

10/004612

Inventors:

Stacy W. Remiszewski - Township of Washington, Bergen County NJ
Alan K. Mallams - Hackettstown NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31496

US Classification:

51425303, 514290, 544361, 546 93

Abstract:

Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

US Patent:

6740661, May 25, 2004

Filed:

Dec 20, 2001

Appl. No.:

10/026999

Inventors:

Arthur G. Taveras - Denville NJ
Ronald J. Doll - Maplewood NJ
Alan B. Cooper - West Caldwell NJ
Johan A. Ferreira - Bensalem PA
Timothy Guzi - Chatham NJ
Alan K. Mallams - Hackettstown NJ
Dinanath F. Rane - Morganville NJ
Viyyoor M. Girijavallabhan - Parsippany NJ
Adriano Afonso - West Caldwell NJ
Cynthia J. Aki - Rutherford NJ
Jianping Chao - Summit NJ
Carmen Alvarez - Roselle Park NJ
Joseph M. Kelly - Parlin NJ
Tarik Lalwani - Philadelphia PA
Jagdish A. Desai - Spotswood NJ
James J-S Wang - Westfield NJ
Jay Weinstein - Upper Montclair NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514290, 514326, 51425501, 51425211, 51425303, 51425405, 514256, 546 93, 546210, 544361, 544370, 544333, 544357

Abstract:

Disclosed are compounds of the formula: wherein R represents an imidazole ring; R represents a carbamate, urea, amide or sulfonamide group; R represents H when the alkyl chain between the amide group and the R imidazole group is substituted, or R represents a substituent such as arylalkyl, heteroarylalkyl or cycloalkyl; and the remaining substituents are as defined herein. Also disclosed are compounds wherein R is H, and the alkyl chain between the amide group and the R imidazole group is unsubstituted. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.

US Patent:

6800636, Oct 5, 2004

Filed:

Dec 20, 2001

Appl. No.:

10/028251

Inventors:

Timothy Guzi - Chatham NJ
Dinanath F. Rane - Morganville NJ
Alan K. Mallams - Hackettstown NJ
Alan B. Cooper - West Caldwell NJ
Ronald J. Doll - Maplewood NJ
Viyyoor M. Girijavallabhan - Parsippany NJ
Arthur G. Taveras - Denville NJ
Corey Strickland - North Plainfield NJ
Joseph M. Kelly - Parlin NJ
Jianping Chao - Summit NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514290, 514325, 51425302, 51421705, 5142282, 5142328, 514218, 546 93, 546195, 546203, 540544, 540598, 540575, 544 60, 544121, 544361, 544370, 544360

Abstract:

Disclosed are compounds of the formula: wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.