Alan Gary Palestine

US Patent:

52946045, Mar 15, 1994

Filed:

Dec 20, 1989

Appl. No.:

7/453793

Inventors:

Robert B. Nussenblatt - Bethesda MD
Alan G. Palestine - Potomac MD

Assignee:

The Government of the United States of America as represented by the
Secretary of the Department of Health and Human Services - Washington DC

International Classification:

A61K 3702
C07K 706
C07K 512

US Classification:

514 11

Abstract:

The present invention provides a method of treating ocular diseases by the administration of cyclosporine A or G by periocular injection in a pharmaceutically acceptable carrier.

US Patent:

59619775, Oct 5, 1999

Filed:

Apr 10, 1995

Appl. No.:

8/419505

Inventors:

David Allen Hafler - Newton MA
Robert B. Nussenblatt - Bethesda MD
Alan G. Palestine - Potomac MD
Howard L. Weiner - Brookline MA

Assignee:

AutoImmune Inc. - Lexington MA
The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

A61K 3900
A61K 3938
A61K 3800
C07K 500

US Classification:

4241841

Abstract:

The present invention provides a method of treating or preventing the clinical manifestation of an autoimmune disease having the symptoms of uveoretinitis in a mammal in need of such treatment comprising orally administering to said mammal an effective amount of an autoantigen, e. g. , S antigen (S-Ag), and/or biologically active fragments, or analogs thereof specific for uveoretinitis. Also provided is a pharmaceutical formulation useful for treating or preventing uveoretinitis in mammals comprising an effective amount of one or more of the foregoing autoantigen, fragments or analogs.