Alan I West

US Patent:

7588550, Sep 15, 2009

Filed:

Jul 11, 2007

Appl. No.:

11/776360

Inventors:

Edward F. Leonard - Scarsdale NY, US
Alan C. West - Tenafly NJ, US
Zhongliang Tang - San Diego CA, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61M 37/00
B32B 27/04
B32B 27/12

US Classification:

604 504, 604 401, 604 501, 604 611, 604 616, 422 44

Abstract:

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

US Patent:

7727399, Jun 1, 2010

Filed:

May 22, 2007

Appl. No.:

11/814117

Inventors:

Edward F. Leonard - Scarsdale NY, US
Alan C. West - Tenafly NJ, US
Christian P. Aucoin - New York NY, US
Edgar E. Nanne - New York NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

B01D 61/38
B01D 61/24
B01D 61/14
A61M 1/34
A61M 37/00
B01D 11/00

US Classification:

210643, 210634, 210644, 210645, 210646, 210649, 210650, 210651, 604 501, 604 504, 604 601, 604 602, 604 609

Abstract:

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

US Patent:

7850633, Dec 14, 2010

Filed:

Jul 24, 2009

Appl. No.:

12/509395

Inventors:

Edward F. Leonard - Bronxville NY, US
Alan C. West - Tenafly NJ, US
Nina C. Shapley - New York NY, US
Zhongliang Tang - San Diego CA, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61M 1/34
B01D 61/24
B01D 61/14
B01D 61/38

US Classification:

604 504, 210643, 210645, 210646, 210767, 210805, 604 401, 604 501, 604 609, 604 611, 604 616

Abstract:

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

US Patent:

8021318, Sep 20, 2011

Filed:

Nov 9, 2010

Appl. No.:

12/942519

Inventors:

Edward F. Leonard - Bronxville NY, US
Alan C. West - Tenafly NJ, US
Nina C. Shapley - New York NY, US
Zhongliang Tang - San Diego CA, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61M 1/34
B01D 61/24
B01D 61/14
B01D 61/38

US Classification:

604 504, 210643, 210645, 210646, 210767, 210805, 604 401, 604 501, 604 609, 604 611, 604 616

Abstract:

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

US Patent:

8083706, Dec 27, 2011

Filed:

Jul 7, 2009

Appl. No.:

12/499038

Inventors:

Edward F. Leonard - Bronxville NY, US
Alan C. West - Tenafly NJ, US
Nina C. Shapley - New York NY, US
Zhongliang Tang - San Diego CA, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61M 37/00
A61M 29/00
G10N 21/00
G01N 31/00
G01N 33/00
B01D 21/24
B01D 25/30
B01D 33/70
B01D 11/00
B01D 12/00

US Classification:

604 504, 604 501, 604 601, 604 602, 604 609, 604 611, 422 81, 422 82, 422 99, 422101, 209155, 209156, 210 97, 210137, 210200, 210203, 210209, 210511, 210634, 210645, 210646, 210806

Abstract:

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

US Patent:

8092684, Jan 10, 2012

Filed:

Nov 17, 2010

Appl. No.:

12/948325

Inventors:

Edward F. Leonard - Bronxville NY, US
Alan C. West - Tenafly NJ, US
Christian Paul Aucoin - New York NY, US
Edgar E. Nanne - Bronx NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

B01D 61/38
B01D 61/24
B01D 61/14
B01D 11/00
A61M 1/34
A61M 37/00

US Classification:

210643, 210634, 210644, 210645, 210646, 210649, 210650, 210651, 604 501, 604 504, 604 601, 604 602, 604 609

Abstract:

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

US Patent:

8097153, Jan 17, 2012

Filed:

Apr 13, 2010

Appl. No.:

12/759157

Inventors:

Edward F. Leonard - Bronxville NY, US
Alan C. West - Tenafly NJ, US
Christian Paul Aucoin - New York NY, US
Edgar E. Nanne - Bronx NY, US

Assignee:

The Trustees of Columbia in the City of New York - New York NY

International Classification:

B01D 61/38
B01D 61/24
B01D 61/14
B01D 11/00
A61M 1/34
A61M 37/00

US Classification:

210203, 210 97, 210137, 210200, 210209, 210511, 210644, 210645, 210646, 210647, 210649, 210650, 210651, 210634, 210643, 210767, 210806, 604 401, 604 501, 604 601, 604 602, 604 609, 422 81, 422 82, 422 99, 209155, 209196

Abstract:

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

US Patent:

8097162, Jan 17, 2012

Filed:

Nov 17, 2010

Appl. No.:

12/948284

Inventors:

Edward F. Leonard - Bronxville NY, US
Alan C. West - Tenafly NJ, US
Christian Paul Aucoin - New York NY, US
Edgar E. Nanne - Bronx NY, US

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

B01D 61/38
B01D 61/24
B01D 61/14
B01D 11/00
A61M 1/34
A61M 37/00

US Classification:

210643, 210511, 210634, 210644, 210645, 210651, 210767, 210806, 604 501, 604 504, 604 601, 604 602, 604 609

Abstract:

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.