Alex K So

age ~59

from Union City, CA

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Regulation Of Macrophage Activation Using Mir-125B
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US Patent:

20120322854, Dec 20, 2012
Filed:

Jun 18, 2012
Appl. No.:

13/526347
Inventors:

Aadel Chaudhuri - Santa Clara CA, US
Alex Steven So - Los Angeles CA, US
David Baltimore - Pasadena CA, US
Ryan M. O'Connell - Salt Lake City UT, US
Assignee:

CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA
International Classification:

A61K 31/7088
A61P 1/00
A61P 19/02
A61P 25/00
US Classification:

514 44 A
Abstract:

The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125or anti-miR-125, to macrophages. For example, in some embodiments, macrophage activation can be elevated or reduced by administering miR-125or anti-miR-125oligonucleotides. Also disclosed are methods for promoting T cell activation and method for treating various disorders such as tumor and autoimmune diseases.

Error Suppression In Sequenced Dna Fragments Using Redundant Reads With Unique Molecular Indices (Umis)
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US Patent:

20210108262, Apr 15, 2021
Filed:

Oct 21, 2020
Appl. No.:

17/076715
Inventors:

- San Diego CA, US
Byoungsok Jung - Atherton CA, US
Emrah Kostem - Redwood City CA, US
Alex Aravanis - San Mateo CA, US
Alex So - San Diego CA, US
Xuyu Cai - Natick MA, US
Zhihong Zhang - San Diego CA, US
Frank J. Steemers - Encinitas CA, US
International Classification:

C12Q 1/6869
G16B 30/00
C12Q 1/6806
C12N 15/10
C12Q 1/6855
Abstract:

The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index (UMI) sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length. In some implementations, the UMIs include both physical UMIs and virtual UMIs. In some implementations, the unique molecular index sequences include non-random sequences. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.

Error Suppression In Sequenced Dna Fragments Using Redundant Reads With Unique Molecular Indices (Umis)
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US Patent:

20160319345, Nov 3, 2016
Filed:

Apr 15, 2016
Appl. No.:

15/130668
Inventors:

- San Diego CA, US
Byoungsok Jung - Atherton CA, US
Emrah Kostem - Redwood City CA, US
Alex Aravanis - San Mateo CA, US
Alex So - San Diego CA, US
Xuyu Cai - Natick MA, US
Zhihong Zhang - San Diego CA, US
International Classification:

C12Q 1/68
C12N 15/10
G06F 19/22
Abstract:

The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index (UMI) sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length. In some implementations, the UMIs include both physical UMIs and virtual UMIs. In some implementations, the unique molecular index sequences include non-random sequences. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.