Alexander Brill

US Patent:

20140199329, Jul 17, 2014

Filed:

May 25, 2012

Appl. No.:

14/119499

Inventors:

Denisa D. Wagner - Dover MA, US
Tobias A. Fuchs - Gunzenbach, DE
Simon De Meyer - Hooglede, BE
Kimberly Martinod - Cambridge MA, US
Alexander Brill - Brookline MA, US
Grace M. Thomas - Boston MA, US

Assignee:

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

International Classification:

A61K 38/46
A61M 1/34
A61K 31/166
A61K 45/06
A61K 39/395

US Classification:

4241721, 424 946, 514616, 4353071, 435 2, 210435

Abstract:

Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries.