Alexander J Nichols

US Patent:

20210000921, Jan 7, 2021

Filed:

Jan 11, 2017

Appl. No.:

16/067948

Inventors:

- Cambridge MA, US
Alexander Nichols - Cambridge MA, US
Douglas Ewen Cameron - Auburndale MA, US
Brett Blackman - Bedford MA, US
Chantal Kuhn - Jamaica Plain MA, US

International Classification:

A61K 38/20
A61K 39/395
C07K 16/28
A61P 31/00
A61P 35/00
A61P 37/04

Abstract:

The invention described herein features methods and compositions for modifying thymic function and/or activity in a subject (e.g., a human, e.g., a human patient in need thereof; or a non-human animal, e.g., a companion animal or an agricultural animal).

US Patent:

20200171172, Jun 4, 2020

Filed:

Feb 11, 2020

Appl. No.:

16/787480

Inventors:

- Boston MA, US
Gabriela Apiou - Boston MA, US
Alexander J. Nichols - Boston MA, US
Emmanouil Rousakis - Boston MA, US
Zongxi Li - Boston MA, US

International Classification:

A61K 49/00
C07D 487/22
A61B 5/00
A61B 5/1455
A61B 90/00

Abstract:

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

US Patent:

20180344878, Dec 6, 2018

Filed:

Aug 3, 2018

Appl. No.:

16/054028

Inventors:

- Boston MA, US
Gabriela Apiou - Boston MA, US
Alexander J. Nichols - Boston MA, US
Emmanouil Rousakis - Boston MA, US
Zongxi Li - Boston MA, US

International Classification:

A61K 49/00
C07D 487/22
A61B 5/1455
A61B 5/00
A61B 90/00
A61F 13/00

Abstract:

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

US Patent:

20170348437, Dec 7, 2017

Filed:

Aug 23, 2017

Appl. No.:

15/684040

Inventors:

- Boston MA, US
Gabriela Apiou - Boston MA, US
Alexander J. Nichols - Boston MA, US
Emmanouil Rousakis - Boston MA, US
Zongxi Li - Boston MA, US

International Classification:

A61K 49/00
A61B 5/00
A61B 5/1455
C07D 487/22

Abstract:

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

US Patent:

20160338631, Nov 24, 2016

Filed:

Feb 2, 2015

Appl. No.:

15/114951

Inventors:

- Boston MA, US
Conor L. Evans - Charlestown MA, US
Alexander J. Nichols - Cambridge MA, US

International Classification:

A61B 5/1455
A61B 5/1477
A61B 5/00
A61F 13/00

Abstract:

In one aspect, the present disclosure provides a system A system, including a light source, a detector, and a controller in electrical communication with the light source and the detector. The controller is configured to execute a program stored in the controller to trigger the light source to emit a first pulse of light having a first pulse duration for illumination of a target, actuate the detector after a first delay time following emission of the first pulse of light to begin detecting a first signal from the target for a first detection time, and repeat the steps of triggering the light source and actuating the detector at least once, varying for each repetition at least one of the first pulse duration, the first delay time, and the first detection time.

US Patent:

20160159842, Jun 9, 2016

Filed:

Jun 13, 2014

Appl. No.:

14/903710

Inventors:

Conor L. Evans - Boston MA, US
Gabriela Apiou - Boston MA, US
Alexander J. Nichols - Boston MA, US
Emmanouil Rousakis - Boston MA, US
Zongxi Li - Boston MA, US

International Classification:

C07F 15/00
A61B 5/00
A61K 49/00
A61B 5/1455

Abstract:

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

US Patent:

20150182166, Jul 2, 2015

Filed:

Jul 10, 2013

Appl. No.:

14/413571

Inventors:

Conor L. Evans - Boston MA, US
Gabriela Apiou - Boston MA, US
Reginald Birngruber - Boston MA, US
Alexander J. Nichols - Boston MA, US
Emmanouil Rousakis - Boston MA, US
Zongxi Li - Boston MA, US

International Classification:

A61B 5/00
A61B 19/00
A61B 5/1455

Abstract:

A system and method are provided for the design and assembly of a device including a sensor capable and a compatible matrix material incorporated into a dressing. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions, and the matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte.