The present invention provides methods for the treatment, and pharmaceuticals for the use in the treatment, of mammalian subjects having, or at risk of developing, chronic demyelinating neuropathies, e.g., CIDP. The methods involve the administration of IFN-β therapeutics.
Therapies For Chronic Inflammatory Demyelinating Polyneuropathy Using Interferon-Ss
The present invention provides methods for the treatment, and pharmaceuticals for the use in the treatment, of mammalian subjects having, or at risk of developing, chronic demyelinating neuropathies, e.g., CIDP. The methods involve the administration of IFN-β therapeutics.
Methods Of Treating Multiple Sclerosis And Preserving And/Or Increasing Myelin Content
- Cambridge MA, US Gilmore O'Neill - Medford MA, US Alfred Sandrock - Newton MA, US
Assignee:
Biogen IDEC MA Inc. - Cambridge MA
International Classification:
A61K 31/225
US Classification:
514547
Abstract:
Methods of treating multiple sclerosis in a subject, including: reducing the frequency of relapse, reducing the annualized relapse rate, reducing the risk of disability progression, reducing the number of new or newly enlarging T2 lesions, reducing the number of gadolinium lesions; and methods of preserving/increasing myelin content in a subject having multiple sclerosis; by daily administering a composition containing a fumarate, such as dimethyl fumarate or monomethyl fumarate, to the subject.
Medicine Doctors
Dr. Alfred W Sandrock, Boston MA - MD (Doctor of Medicine)
15 Parkman St, Boston, MA 02114 (617)7243914 (Phone), (617)7266991 (Fax)
Certifications:
Neurology, 1994
Awards:
Healthgrades Honor Roll
Languages:
English Japanese
Hospitals:
15 Parkman St, Boston, MA 02114
Massachusetts General Hospital 55 Fruit Street, Boston, MA 02114
Education:
Medical School Harvard Medical School Graduated: 1988 Medical School Massachusetts General Hospital Graduated: 1988 Medical School Mass Gen Hosp Graduated: 1988
This is exactly what we do at Biogen -- cutting-edge research and breakthrough therapies, said Alfred Sandrock, the companys chief medical officer. We feel a high sense of urgency to introduce it as soon as [it is] feasible to make sure patients get acccess to this drug.
By collaborating with regulators through programs like Fast Track, we hope to bring effective treatments to patients and families affected by Alzheimers disease as quickly as possible, said Dr. Alfred Sandrock, Biogens executive vice president and chief medical officer.
Incidences of brain-imaging abnormalities called ARIA-E, indicative of fluid build-up in the brain, also cropped up dose-dependently, but these abnormalities were transient. Alfred Sandrock of Biogen in Cambridge, Massachusetts, and Roger Nitsch of Neurimmune in Zurich co-led the trial. Some researc
Date: Sep 02, 2016
Category: Health
Source: Google
Early Research Shows 'Hint' Of Slowing Alzheimer's, But More Testing Is Needed
Dr. Alfred Sandrock of Cambridge-based Biogen, and the study's senior author, summed up the researchhighlightsduring a press briefing in advance of the paper's release. He said the studyshowed that treatment with aducanumab, a human-derived monoclonal antibody, resulted in reducing the potentiall
We are pretty certain of the fact that the antibody reduces the amyloid plaques and in some ways gets rid of the majority of it, says Alfred Sandrock, senior author of the paper from Massachusetts-based Biogen. Thats important because if we really want to treat Alzheimers at even the very earli
Date: Aug 31, 2016
Category: Sci/Tech
Source: Google
Biogen (BIIB), Ionis (IONS) Announce Nusinersen Phase 3 Met Primary Endpoint in Infantile-Onset SMA
rticipating in the clinical trials, who continue to inspire us. We want to thank them, along with the investigators who have worked tirelessly on this program and the broader SMA community, for their partnership. Without their contributions, we would not be here today, said Alfred Sandrock, M.D., Ph
Date: Aug 01, 2016
Category: Health
Source: Google
Biogen Shells Out $75M to Develop Ionis' Nusinersen after Positive Phase III Results
We remain committed to understanding the potential of nusinersen in the broader SMA population and will continue to focus on the rapid completion of our ongoing studies, Alfred Sandrock, M.D., Ph.D., Biogen evp and CMO, said in a statement. We share the communitys sense of urgency as we strive t
Date: Aug 01, 2016
Category: Business
Source: Google
Biogen tumbles on PhII MS flop, but refuses to write off drug
Despite these setbacks, Biogen has seen something in the data that could compel it to continue with development of the antibody. While we missed the primary endpoint, the SYNERGY study results suggest evidence of a clinical effect of opicinumab, Biogen CMO Alfred Sandrock said in a statement. Due