Alison E Baird

US Patent:

20060046259, Mar 2, 2006

Filed:

Jun 17, 2005

Appl. No.:

11/155835

Inventors:

Alison Baird - Bethesda MD, US
David Moore - Rockville MD, US
Ehud Goldin - Rockville MD, US

International Classification:

C12Q 1/68
G01N 33/00

US Classification:

435006000, 436086000

Abstract:

Methods are provided for evaluating a stroke, for example for determining whether a subject has had an ischemic stroke, determining the severity or likely neurological recovery of a subject who has had an ischemic stroke, and determining a treatment regimen for a subject who has had an ischemic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression in ischemic stroke related genes (or proteins), such as white blood cell activation and differentiation genes (or proteins), genes (or proteins) related to hypoxia, genes (or proteins) involved in vascular repair, and genes (or proteins) related to a specific peripheral blood mononuclear cell (PBMC) response to the altered cerebral microenvironment. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of an ischemic stroke-related molecule.

US Patent:

20100086481, Apr 8, 2010

Filed:

Jul 11, 2007

Appl. No.:

12/307910

Inventors:

Alison E. Baird - Brooklyn NY, US
David F. Moore - Rockville MD, US
Ehud Goldin - Rockville MD, US
Kory Johnson - Rockville MD, US

International Classification:

C12Q 1/68
C40B 40/06
C40B 40/10
A61K 49/00

US Classification:

424 91, 435 6, 506 16, 506 18

Abstract:

Methods are provided for evaluating a stroke, for example for determining whether a subject has had a hemorrhagic stroke, determining the severity or likely neurological recovery of a subject who has had a hemorrhagic stroke, and determining a treatment regimen for a subject who has had a hemorrhagic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression of hemorrhagic stroke related genes (or proteins), such as genes (or proteins) involved in suppression of the immune response, genes (or proteins) involved in vascular repair, genes (or proteins) involved in the acute inflammatory response, genes (or proteins) involved in cell adhesion, genes (or proteins) involved in hypoxia, genes (or proteins) involved in signal transduction, and genes (or proteins) involved in the response to the altered cerebral microenvironment. Arrays and kits are provided that can be used in the disclosed methods. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of a hemorrhagic stroke-related molecule.

US Patent:

20100267582, Oct 21, 2010

Filed:

Jul 1, 2010

Appl. No.:

12/829229

Inventors:

ALISON E. BAIRD - BETHESDA MD, US
DAVID F. MOORE - ROCKVILLE MD, US
EHUD GOLDIN - ROCKVILLE MD, US

International Classification:

C40B 30/04
C12Q 1/68
C40B 40/08

US Classification:

506 9, 435 6, 506 17

Abstract:

Methods are provided for evaluating a stroke, for example for determining whether a subject has had an ischemic stroke, determining the severity or likely neurological recovery of a subject who has had an ischemic stroke, and determining a treatment regimen for a subject who has had an ischemic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression in ischemic stroke related genes (or proteins), such as white blood cell activation and differentiation genes (or proteins), genes (or proteins) related to hypoxia, genes (or proteins) involved in vascular repair, and genes (or proteins) related to a specific peripheral blood mononuclear cell (PBMC) response to the altered cerebral microenvironment. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of an ischemic stroke-related molecule.