Allan Xi Chen

US Patent:

7037901, May 2, 2006

Filed:

Feb 12, 2002

Appl. No.:

10/075718

Inventors:

Allan Y. Chen - Sacramento CA, US

Assignee:

University of California - Davis CA

International Classification:

A61K 31/70
A61K 31/40

US Classification:

514 43, 514410, 514416

Abstract:

The present invention is based on the discovery of a composition that provides radiosensitization effect. Specifically the composition contains an indolocarbazole derivative. The present invention provides methods for radiosensitizing neoplastic cells using indolocarbazole derivatives and methods for treating neoplastic cells using indolocarbazole derivatives in combination with radiation or radiation and chemotherapy.

US Patent:

20200324145, Oct 15, 2020

Filed:

Jun 18, 2020

Appl. No.:

16/905342

Inventors:

- Redwood City CA, US
Craig Mathew Brown - Santa Clara CA, US
Allan Xi Chen - Daly City CA, US
Charles Kevin Gary - Palo Alto CA, US
Yao Zong Guan - San Francisco CA, US
Yoshio Horii - Fukushima, JP
Yuji Kokubo - Fukushima, JP
Naoyuki Yamada - Fukushima, JP
Shotaro Komura - Fukushima, JP

Assignee:

Adelphi Technology, Inc. - Redwood City CA

International Classification:

A61N 5/10
G21G 4/02

Abstract:

A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber for a subject, and eight substantially identical neutron generators, each comprising a pre-moderator block. The eight neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.

US Patent:

20200316405, Oct 8, 2020

Filed:

Jun 18, 2020

Appl. No.:

16/905261

Inventors:

- Redwood City CA, US
Craig Mathew Brown - Santa Clara CA, US
Allan Xi Chen - Daly City CA, US
Charles Kevin Gary - Palo Alto CA, US
Yao Zong Guan - San Francisco CA, US
Yoshio Horii - Fukushima, JP
Yuji Kokubo - Fukushima, JP
Naoyuki Yamada - Fukushima, JP
Shotaro Komura - Fukushima, JP

Assignee:

Adelphi Technology, Inc. - Redwood City CA

International Classification:

A61N 5/10
G21G 4/02

Abstract:

A Boron neutron cancer treatment system has a central treatment chamber for a subject, with six substantially identical neutron generators each having an acceleration chamber, the generators positioned around a secondary moderator with the axis of each acceleration chamber passing through center of the treatment chamber, and with angled sides of the neutron generators fully adjacent.

US Patent:

20200316406, Oct 8, 2020

Filed:

Jun 18, 2020

Appl. No.:

16/905445

Inventors:

- Redwood City CA, US
Craig Mathew Brown - Santa Clara CA, US
Allan Xi Chen - Daly City CA, US
Charles Kevin Gary - Palo Alto CA, US
Yao Zong Guan - San Francisco CA, US
Yoshio Horii - Fukushima, JP
Yuji Kokubo - Fukushima, JP
Naoyuki Yamada - Fukushima, JP
Shotaro Komura - Fukushima, JP

Assignee:

Adelphi Technology, Inc. - Redwood City CA

International Classification:

A61N 5/10
G21G 4/02

Abstract:

A treatment system for evaluating boron sources for boron neutron cancer therapy (BNCT) has a substantially square secondary moderator having a central treatment chamber for a subject; and four substantially identical neutron generators positioned around the substantially square secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber.

US Patent:

20200316407, Oct 8, 2020

Filed:

Jun 18, 2020

Appl. No.:

16/905538

Inventors:

- Redwood City CA, US
Craig Mathew Brown - Santa Clara CA, US
Allan Xi Chen - Daly City CA, US
Charles Kevin Gary - Palo Alto CA, US
Yao Zong Guan - San Francisco CA, US
Yoshio Horii - Fukushima, JP
Yuji Kokubo - Fukushima, JP
Naoyuki Yamada - Fukushima, JP
Shotaro Komura - Fukushima, JP

Assignee:

Adelphi Technology, Inc. - Redwood City CA

International Classification:

A61N 5/10
G21G 4/02

Abstract:

A Boron neutron cancer treatment system has a moderator chamber filled with liquid or granular moderator material except for a central treatment chamber, the moderator chamber having parallel upper and lower surfaces, and a plurality of modular neutron generators fully immersed in the liquid or granular moderator material of the moderator chamber.

US Patent:

20200246638, Aug 6, 2020

Filed:

Feb 26, 2020

Appl. No.:

16/801918

Inventors:

- Redwood City CA, US
Craig Mathew Brown - Santa Clara CA, US
Allan Xi Chen - Daly City CA, US
Charles Kevin Gary - Palo Alto CA, US
Yao Zong Guan - San Francisco CA, US
Yoshio Horii - Fukushima, JP
Yuji Kokubo - Fukushima, JP
Naoyuki Yamada - Fukushima, JP
Shotaro Komura - Fukushima, JP

Assignee:

Adelphi Technology, Inc. - Redwood City CA

International Classification:

A61N 5/10
G21G 4/02

Abstract:

A Boron neutron cancer treatment system has a secondary moderator having a central treatment chamber, and several generators, each comprising a pre-moderator block, an acceleration chamber, a vacuum pump engaging the acceleration chamber at a right angle, a plasma ion chamber opening into the acceleration chamber, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a cylindrical primary isolation well extending into the pre-moderator block, a secondary isolation well surrounding the primary isolation well, and a water-cooled titanium target disk at a lower extremity of the isolation well. The neutron generators are positioned around the secondary moderator with the axis of each acceleration chamber passing through the center of the treatment chamber, and with the angled sides of the neutron generators fully adjacent.

US Patent:

20200069974, Mar 5, 2020

Filed:

Oct 24, 2019

Appl. No.:

16/662523

Inventors:

- Redwood City CA, US
Craig Mathew Brown - Santa Clara CA, US
Allan Xi Chen - Daly City CA, US
Charles Kevin Gary - Palo Alto CA, US
Yao Zong Guan - San Francisco CA, US
Yoshio Horii - Fukushima, JP
Yuji Kokubo - Fukushima, JP
Naoyuki Yamada - Fukushima, JP
Shotaro Komura - Fukushima, JP

Assignee:

Adelphi Technology, Inc. - Redwood City CA

International Classification:

A61N 5/10
G21G 4/02

Abstract:

A neutron generator has a pre-moderator block of moderating material, an acceleration chamber, a vacuum pump evacuating the acceleration chamber to a moderately high vacuum, a plasma ion chamber opening into the acceleration chamber through an ion extraction iris, a gas source providing deuterium gas to the plasma ion chamber, a microwave energy source ionizing the gas in the plasma ion chamber, a primary and a secondary isolation well extending into the pre-moderator block, a water-cooled titanium target disk positioned at a lower extremity of the primary isolation well, the target disk biased to a substantial negative DC voltage, and electrically grounded metal cladding covering surfaces of the pre-moderator block. Ions extracted through the ion extraction iris are accelerated to bombard the titanium target producing energetic neutrons that pass through and are moderated by the pre-moderator block.