Amale A Hawi

US Patent:

20110263720, Oct 27, 2011

Filed:

Mar 9, 2011

Appl. No.:

13/044056

Inventors:

Steven D. PAISLEY - Danbury CT, US
Jason M. LePree - Demarest NJ, US
Amale Hawi - Ridgefield CT, US
Michael Eckhoff - Ridgefield CT, US

Assignee:

Penwest Pharmaceuticals Co. - Patterson NY

International Classification:

A61K 31/122
C07C 49/497
A61P 25/00
A61P 3/10
A61P 25/28
A61P 25/18
A61P 35/00
C07C 45/60
A61P 25/08

US Classification:

514678, 568323, 568308

Abstract:

The present invention is directed to a method of synthesizing a compound of Formula I:the method comprising oxidizing alpha-tocopherol with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4. The invention is also directed to a method of synthesizing a compound of Formula I, the method comprising (a) hydrolyzing alpha-tocopheryl acetate in the presence of a base; (b) neutralizing the hydrolyzing of (a), thereby forming alpha-tocopherol; and (c) oxidizing the alpha-tocopherol of (b) with a metal salt oxidizing agent to form the compound of Formula I, wherein the stoichiometric ratio (mol/mol) of metal salt oxidizing agent/alpha-tocopherol is 1.6 to 4.

US Patent:

20120101169, Apr 26, 2012

Filed:

Jul 11, 2011

Appl. No.:

13/180185

Inventors:

Amale HAWI - Ridgefield CT, US

Assignee:

Penwest Pharmaceuticals Co. - Chadds Ford PA

International Classification:

A61K 31/122
C07C 49/713
A61P 9/00
C07C 39/11
A61P 7/02
A61P 9/10
A61K 31/05
C07C 39/24

US Classification:

514690, 514734, 568377, 568765, 568763

Abstract:

The present invention is directed to methods of providing anticoagulation effects in subjects in need thereof, comprising administering to the subjects at least twice a day compounds of the present invention, stereoisomers, and racemates thereof.

US Patent:

61720593, Jan 9, 2001

Filed:

Aug 11, 1998

Appl. No.:

9/131829

Inventors:

Karl G. Grozinger - Ridgefield CT
Amale A. Hawi - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

A61K 31551

US Classification:

514220

Abstract:

An aqueous pharmaceutical suspension consisting essentially of nevirapine hemihydrate having a particle size between about 1 and 150 microns in diameter.

US Patent:

62554816, Jul 3, 2001

Filed:

Mar 2, 2000

Appl. No.:

9/517564

Inventors:

Karl G. Grozinger - Ridgefield CT
Amale A. Hawi - Danbury CT

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield

International Classification:

C07D24310
A61K 914
A61K 3155

US Classification:

540495

Abstract:

An aqueous pharmaceutical suspension consisting essentially of nevirapine hemihydrate having a particle size between about 1 and 150 microns in diameter.

US Patent:

20220347171, Nov 3, 2022

Filed:

Dec 8, 2021

Appl. No.:

17/545487

Inventors:

- New Haven CT, US
Jennifer L. Good - Sandy Hook CT, US
Amale Hawi - Ridgefield CT, US

International Classification:

A61K 31/485
A61P 17/04
A61K 9/00

Abstract:

The present invention relates to methods for treating prurigo nodularis with anti-pruritic compositions, wherein the method provides a therapeutic effect in a patient.

US Patent:

20200016150, Jan 16, 2020

Filed:

Jul 10, 2019

Appl. No.:

16/507433

Inventors:

- New Haven CT, US
Amale Hawi - Ridgefield CT, US

International Classification:

A61K 31/485
A61P 1/16
A61K 9/00
A61K 45/06
A61K 9/20

Abstract:

The present disclosure relates to methods for treating patients with pruritus associated with liver disease with anti-pruritic compositions; methods for treating patients with pruritus associated with obstructive cholestasis secondary to bile duct obstruction due to non-hepatic tissue disease; and the anti-pruritic compositions used in such methods.

US Patent:

20180125840, May 10, 2018

Filed:

Oct 25, 2017

Appl. No.:

15/793153

Inventors:

- New Haven CT, US
Jennifer L. Good - Sandy Hook CT, US
Amale Hawi - Ridgefield CT, US

International Classification:

A61K 31/485
A61P 17/04
A61K 9/00
A61K 45/06

Abstract:

The present invention relates to methods for treating prurigo nodularis with anti-pruritic compositions, wherein the method provides a therapeutic effect in a patient.

US Patent:

20180008592, Jan 11, 2018

Filed:

Mar 21, 2017

Appl. No.:

15/465158

Inventors:

- New Haven CT, US
Jennifer L. Good - Sandy Hook CT, US
Amale Hawi - Ridgefield CT, US

International Classification:

A61K 31/485
A61K 9/20
A61K 9/00
A61K 45/06

Abstract:

The present invention relates to methods for treating uremic pruritus with anti-pruritic compositions, wherein the method provides a therapeutic effect in a patient.