Amy Lynn Gryshuk

US Patent:

7820143, Oct 26, 2010

Filed:

Feb 19, 2009

Appl. No.:

12/378751

Inventors:

Ravindra K. Pandey - Williamsville NY, US
Amy Gryshuk - Pleasanton CA, US
Lalit Goswami - Amherst NY, US
William Potter - Grand Island NY, US
Allan Oseroff - Buffalo NY, US

Assignee:

Health Research, Inc. - Buffalo NY

International Classification:

A61B 5/055

US Classification:

424 93, 424 961, 514279, 514410

Abstract:

A tetrapyrollic photosensitizer compound having at least one pendant —CHCHCON(CHCON(CHCOOH))or —N(CHCOOH)group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula:.

US Patent:

8198432, Jun 12, 2012

Filed:

Aug 5, 2009

Appl. No.:

12/462535

Inventors:

Ravindra K. Pandey - Williamsville NY, US
Munawwar Sajjad - Clarence Center NY, US
Suresh Pandey - Chelmsford MA, US
Amy Gryshuk - Livermore CA, US
Allan Oseroff - Buffalo NY, US
Stephanie Pincus, legal representative - Buffalo NY, US
Hani A. Nabi - Clarence NY, US

Assignee:

Health Research, Inc. - Buffalo NY
The Research Foundation of SUNY - Amherst NY

International Classification:

C07B 47/00
C07D 487/22

US Classification:

540145

Abstract:

This invention describes a first report on the synthesis of certain I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.

US Patent:

8586759, Nov 19, 2013

Filed:

Feb 28, 2011

Appl. No.:

13/037106

Inventors:

Amy L. Gryshuk - Livermore CA, US
Julie Perkins - Sunnyvale CA, US
John V. LaTour - Alameda CA, US

Assignee:

Lawrence Livermore National Security, LLC - Livermore CA

International Classification:

C07D 277/68

US Classification:

548178

Abstract:

Methods and systems to generate 6-amino-6-deoxy--luciferin precursor, 2-cyano-6-aminobenzothiazole and related compounds and derivatives.

US Patent:

20060198783, Sep 7, 2006

Filed:

Feb 14, 2006

Appl. No.:

11/353626

Inventors:

Ravindra Pandey - Williamsville NY, US
Munawwar Sajjad - Clarence Center NY, US
Suresh Pandey - Buffalo NY, US
Amy Gryshuk - Pleasanton CA, US
Allan Oseroff - Buffalo NY, US
Hani Nabi - Clarence NY, US

Assignee:

Health Research, Inc., Roswell Park Cancer Institute Division - Buffalo NY
The Research Foundation of State University of New York - Amherst NY

International Classification:

A61K 51/00
A61M 36/14
C07H 17/02

US Classification:

424001110, 540145000, 536017400, 534011000

Abstract:

This invention describes a first report on the synthesis of certain I-labelled photosensitizers related to chlorines and bacteriochlorins with long wavelength absorption in the range of 660-800 nm. In preliminary studies, these compounds show a great potential for tumor detection by positron emission tomography (PET) and treatment by photodynamic therapy (PDT). The development of tumor imaging or improved photodynamic therapy agent(s) itself represent an important step, but a dual function agent (PET imaging and PDT) provides the potential for diagnostic body scan followed by targeted therapy.

US Patent:

20070149497, Jun 28, 2007

Filed:

Jun 14, 2006

Appl. No.:

11/452511

Inventors:

Ravindra Pandey - Williamsville NY, US
Amy Gryshuk - Pleasanton CA, US
Lalit Goswami - Amherst NY, US
William Potter - Grand Island NY, US
Allan Oseroff - Buffalo NY, US

Assignee:

Health Research, Inc. - Buffalo NY

International Classification:

A61K 31/555
C07D 487/22
A61K 31/409

US Classification:

514185000, 540145000, 514410000

Abstract:

A tetrapyrollic photosensitizer compound having at least one pendant —CHCHCON(CHCON(CHCOOH))or —N(CHCOOH)group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula: or a pharmaceutically acceptable derivative thereof, wherein R-Rand Rare various substituents and Ris substituted or unsubstituted —CHCHCON(CHCON(CHCOOH)); or —N(CHCOOH). The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.

US Patent:

20110091390, Apr 21, 2011

Filed:

Oct 26, 2010

Appl. No.:

12/912033

Inventors:

Ravindra K. Pandey - Williamsville NY, US
Amy Gryshuk - Pleasanton CA, US
Lalit Goswami - Amherst NY, US
William Potter - Grand Island NY, US
Allan Oseroff - Buffalo NY, US

Assignee:

Health Research, Inc. - Buffalo NY

International Classification:

A61K 49/00
A61P 35/00

US Classification:

424 961, 424 96

Abstract:

A tetrapyrollic photosensitizer compound having at least one pendant —CHCHCON(CHCON(CHCOOH))or —N(CHCOOH)group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula:or a pharmaceutically acceptable derivative thereof, wherein R—Rand Rare various substituents and Ris substituted or unsubstituted —CHCHCON(CHCON(CHCOOH)); or —N(CHCOOH). The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.

US Patent:

20110213124, Sep 1, 2011

Filed:

Feb 28, 2011

Appl. No.:

13/037163

Inventors:

Amy L. GRYSHUK - Livermore CA, US
Julie Perkins - Sunnyvale CA, US

International Classification:

C07K 7/06
C07K 1/113

US Classification:

530329, 530345

Abstract:

Methods and systems to generate 6-amino-6-deoxy--luciferin precursor, 2-cyano-6-aminobenzothiazole and related compounds and derivatives