Amy J Hall

US Patent:

20200361939, Nov 19, 2020

Filed:

May 13, 2020

Appl. No.:

15/931256

Inventors:

- Boston MA, US
Cavan McKeon BLIGH - Melrose MA, US
Diane BOUCHER - South Hamilton MA, US
Michael John BOYD - Sharon MA, US
Michael Aaron BRODNEY - Newton MA, US
Michael Philip CLARK - Concord MA, US
Veronique DAMAGNEZ - Boston MA, US
Lev Tyler Dewey FANNING - San Marcos CA, US
Robert Francis FIMOGNARI - Brookline MA, US
Gabrielle Simone FLEMING - Boston MA, US
Kevin James GAGNON - Burlington MA, US
Pedro Manuel GARCIA BARRANTES - Melrose MA, US
Robert Daniel GIACOMETTI - Malden MA, US
Simon GIROUX - Cambridge MA, US
Samantha GUIDO - Quincy MA, US
Amy Beth HALL - Wellesley Hills MA, US
Sarah Carol HOOD - Worcester MA, US
Dennis James HURLEY - San Marcos CA, US
Peter Jones - Sharon MA, US
Sarathy KESAVAN - Quincy MA, US
Mei-Hsiu LAI - Waltham MA, US
Siying LIU - Malden MA, US
Adam LOOKER - Newtonville MA, US
Brad MAXWELL - Holliston MA, US
John Patrick MAXWELL - Hingham MA, US
Ales MEDEK - Winchester MA, US
Kirk Alan OVERHOFF - Lynn MA, US
Setu RODAY - Arlington MA, US
Stefanie ROEPER - Medford MA, US
Steven M. RONKIN - Watertown MA, US
Rupa SAWANT - Wayland MA, US
Yi SHI - Natick MA, US
Muna SHRESTHA - Belmont MA, US
Marisa SPOSATO - Cambridge MA, US
Kathy STAVROPOULOS - Quincy MA, US
Rebecca Jane SWETT - Somerville MA, US
Timothy Lewis TAPLEY - Cardiff CA, US
Qing TANG - Boxborough MA, US
Stephen THOMSON - Del Mar CA, US
Jinwang XU - Framingham MA, US
Mariam ZAKY - Boston MA, US

International Classification:

C07D 487/04
C07D 491/18
C07H 15/26
C07D 519/00
C07F 9/6561
C07D 513/04
A61K 9/16
A61K 31/4162

Abstract:

The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.