Amy T Lee

US Patent:

7049132, May 23, 2006

Filed:

Jun 28, 2000

Appl. No.:

09/606804

Inventors:

Amy S. Lee - San Marino CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

C12N 15/00
C12N 15/09
C12N 15/63
C12N 15/70
C12N 15/74

US Classification:

4353201, 514 44, 424 932

Abstract:

This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78 (grp78) stress-responsive promoter and its use in gene therapy and the production of transgenic animals.

US Patent:

7378427, May 27, 2008

Filed:

Jun 17, 2005

Appl. No.:

11/155851

Inventors:

Brian Hugh Ridgway - Belmont CA, US
William Jay Moore - Collegeville PA, US
Mark Anthony Ashwell - Carlisle MA, US
William Ronald Solvibile - East Windsor NJ, US
Amy Tsai-Ting Lee - Los Altos CA, US
Molly Elizabeth Hoke - Hightstown NJ, US
Madelene Antane - West Windsor NJ, US
Amedeo A. Failli - Princeton Junction NJ, US

Assignee:

Wyeth - Madison NJ

International Classification:

A61K 31/44
C07D 221/12

US Classification:

514298, 546108

Abstract:

Synthetic methods are provided for production of compounds of the formula:.

US Patent:

7666220, Feb 23, 2010

Filed:

Jul 7, 2006

Appl. No.:

11/482503

Inventors:

Michael A. Evans - Palo Alto CA, US
Gwendolyn A. Watanabe - Sunnyvale CA, US
Amy Lee - Sunnyvale CA, US
Steven L. Herbowy - Palo Alto CA, US

Assignee:

Nellix, Inc. - Palo Alto CA

International Classification:

A61F 2/06

US Classification:

623 125, 623 132

Abstract:

Embodiments provide methods and systems for treating aneurysms using filling structures filled with a curable medium. An embodiment of a method comprises positioning at least one double-walled filling structure across the aneurysm and filling the structure(s) with a filling medium so that an outer wall conforms to the inside of the aneurysm and an inner wall forms a generally tubular lumen to provide for blood flow. The lumen is supported with a balloon or other expandable device while and/or after filling. The pressure within the structure and/or in the space between an external wall of the structure and the aneurysm wall is monitored and a flow of the medium into the structure is controlled responsive to the pressure. The pressure can also be used to determine a filling endpoint. The medium is hardened while the lumen remains supported by the balloon.

US Patent:

7790273, Sep 7, 2010

Filed:

May 23, 2007

Appl. No.:

11/752750

Inventors:

Amy Lee - Mountain View CA, US
Michael A. Evans - Palo Alto CA, US

Assignee:

Nellix, Inc. - Palo Alto CA

International Classification:

A61F 2/06
B32B 27/06
B32B 27/16
B32B 27/32

US Classification:

428213, 4283066, 428421, 428422, 428523, 623 12, 623 144

Abstract:

The present invention provides multilayered materials, such as films usable in particular in medical devices in the form of vascular grafts, biocompatible coverings, and/or inflatable bladders, prosthesis for the endoluminal treatment of aneurysms, particularly aortic aneurysms including both abdominal aortic aneurysms (AAA's) and thoracic aortic aneurysms (TAA's).

US Patent:

7923243, Apr 12, 2011

Filed:

Aug 27, 2004

Appl. No.:

10/928806

Inventors:

Amy S. Lee - San Marino CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

C12N 15/00

US Classification:

4353201

Abstract:

This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78 (grp78) stress-responsive promoter and its use in gene therapy and the production of transgenic animals.

US Patent:

7951448, May 31, 2011

Filed:

Aug 17, 2010

Appl. No.:

12/858274

Inventors:

Amy Lee - Mountain View CA, US
Michael A. Evans - Palo Alto CA, US

Assignee:

Nellix, Inc. - Palo Alto CA

International Classification:

A61F 2/06
B32B 3/10
B32B 27/06
B32B 27/16
B32B 27/40

US Classification:

4283066, 4283084, 428422, 4284231, 623 12, 623 144

Abstract:

The present invention provides multilayered materials, such as films usable in particular in medical devices in the form of vascular grafts, biocompatible coverings, and/or inflatable bladders, prosthesis for the endoluminal treatment of aneurysms, particularly aortic aneurysms including both abdominal aortic aneurysms (AAA's) and thoracic aortic aneurysms (TAA's).

US Patent:

8048145, Nov 1, 2011

Filed:

Apr 28, 2006

Appl. No.:

11/413460

Inventors:

Michael A. Evans - Palo Alto CA, US
Gwendolyn A. Watanabe - Sunnyvale CA, US
Amy Lee - Sunnyvale CA, US
Steven L. Herbowy - San Francisco CA, US

Assignee:

Endologix, Inc. - Irvine CA

International Classification:

A61F 2/06

US Classification:

623 125, 606194, 606195, 623 132

Abstract:

Aneurysms are treated by filling at least one double-walled filling structure with a curable medium within the aneurysm. The filling structures may be delivered over balloon deployment mechanisms in order to shape and open tubular lumens therethrough. Scaffolds are placed into the tubular lumens in order to help maintain the shape, anchor the filling structures in place, and provide improved blood flow transition into and out of the tubular lumens.

US Patent:

8133559, Mar 13, 2012

Filed:

May 4, 2011

Appl. No.:

13/100483

Inventors:

Amy Lee - Mountain View CA, US
Michael A. Evans - Palo Alto CA, US

Assignee:

Endologix, Inc. - Irvine CA

International Classification:

A61F 2/06
B32B 1/00
B32B 27/06
B32B 27/18

US Classification:

428 357, 428421, 600424

Abstract:

The present invention provides multilayered materials, such as films usable in particular in medical devices in the form of vascular grafts, biocompatible coverings, and/or inflatable bladders, prosthesis for the endoluminal treatment of aneurysms, particularly aortic aneurysms including both abdominal aortic aneurysms (AAA's) and thoracic aortic aneurysms (TAA's).