Amy P Lee

US Patent:

7049132, May 23, 2006

Filed:

Jun 28, 2000

Appl. No.:

09/606804

Inventors:

Amy S. Lee - San Marino CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

C12N 15/00
C12N 15/09
C12N 15/63
C12N 15/70
C12N 15/74

US Classification:

4353201, 514 44, 424 932

Abstract:

This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78 (grp78) stress-responsive promoter and its use in gene therapy and the production of transgenic animals.

US Patent:

7923243, Apr 12, 2011

Filed:

Aug 27, 2004

Appl. No.:

10/928806

Inventors:

Amy S. Lee - San Marino CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

C12N 15/00

US Classification:

4353201

Abstract:

This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78 (grp78) stress-responsive promoter and its use in gene therapy and the production of transgenic animals.

US Patent:

8445455, May 21, 2013

Filed:

Apr 12, 2011

Appl. No.:

13/084772

Inventors:

Amy Lee - San Marino CA, US

Assignee:

University of Southern California - Los Angeles CA

International Classification:

A61K 31/70

US Classification:

514 44R

Abstract:

This invention relates to compositions and methods for selective expression of a heterologous nucleic acid sequence in a targeted tissue, and more particularly to the glucose regulated protein 78 (grp78) stress-responsive promoter and its use in gene therapy and the production of transgenic animals.

US Patent:

20050143291, Jun 30, 2005

Filed:

Oct 26, 2004

Appl. No.:

10/975045

Inventors:

Amy Lee - San Marino CA, US

International Classification:

A61K048/00
A61K038/16

US Classification:

514008000, 514044000

Abstract:

This invention relates to compositions and methods for modulating apoptosis by regulating the activity of endoplasmic reticulum transmembrane glucose regulated protein 78 (GRP78).

US Patent:

20060082807, Apr 20, 2006

Filed:

Sep 17, 2004

Appl. No.:

10/943336

Inventors:

Yokichi Tanaka - Forthill Ranch CA, US
Don Purpura - Yorba Linda CA, US
Amy Lee - Cypress CA, US
Bret Hassler - Mission Viejo CA, US

International Classification:

G06F 3/12
G06F 15/00

US Classification:

358001150

Abstract:

Printing an electronic document by dynamically creating a destination identifier and transmitting the electronic document with the destination identifier to a destination e-mail address. A server dynamically stores the electronic document with the associated destination identifier and waits to receive the identification-account information from an input device. An agent verifies the inputted identification-account information with the destination identifier stored on the server. The electronic document(s) associated with the destination identifier is then sent to the printer for printing upon verification.

US Patent:

20080075664, Mar 27, 2008

Filed:

Aug 24, 2007

Appl. No.:

11/844721

Inventors:

Amy Lee - San Marino CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

A61K 31/353
A01K 67/00
A61K 31/6615
A61K 39/395
A61P 3/04
A61P 3/10
G01N 33/15

US Classification:

424009200, 424130100, 514102000, 514456000, 800009000

Abstract:

Provided are methods of increasing resistance to and methods of treating disorders associated with weight gain. Also provided are methods of screening for an agent that prevents or treats a disorder associated with weight gain using animal models heterozygous for IP3R1.

US Patent:

20100015128, Jan 21, 2010

Filed:

Aug 15, 2007

Appl. No.:

12/444076

Inventors:

Amy S. Lee - San Marino CA, US
Richard Cote - Los Angeles CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

A61K 39/395
C12Q 1/68
G01N 33/48
A61K 31/7088
A61K 31/435
A61K 31/337
A61K 31/352

US Classification:

4241301, 435 6, 435 792, 514 44 R, 514 44 A, 514284, 514449, 514456

Abstract:

The present application provides methods for detecting, diagnosing, monitoring, predicting responsiveness to therapeutic agents and staging cancer. The present application provides methods and compositions useful for suppression of GRP78 expression or activity in cancer cells to overcome resistance of certain therapeutic agents. The present application also provides methods for predicting whether a subject with cancer is at risk for developing resistance to certain therapeutic agents.

US Patent:

20100239596, Sep 23, 2010

Filed:

Aug 22, 2008

Appl. No.:

12/674583

Inventors:

Amy S. Lee - San Marino CA, US
Florence Hofman - Venice CA, US

Assignee:

UNIVERSITY OF SOUTHERN CALIFORNIA - Los Angeles CA

International Classification:

A61K 39/395
A61K 31/713
A61K 31/352
A61K 31/60
A61K 31/704
A61K 38/14
A61P 35/00

US Classification:

4241721, 514 44 A, 514456, 514159, 514 34, 514 31

Abstract:

Methods of preventing or reducing tumor angiogenesis in a subject, comprising administering to the subject one or more agents that inhibit expression or activity of GRP78 are provided. Also provided are methods of sensitizing tumor blood vessels to a chemotherapeutic agent comprising administering to the subject one or more agents that inhibit expression or activity of GRP78. Provided is also a method of reducing tumor microvessel density in a subject, comprising selecting a subject with a tumor, wherein the subject is in need of reduction of tumor microvessel density, and administering to the subject one or more agents that inhibit expression or activity of GRP78.