Amy Lee Newman

US Patent:

52583864, Nov 2, 1993

Filed:

Jun 5, 1991

Appl. No.:

7/715084

Inventors:

Amy H. Newman - Silver Spring MD
Frank C. Tortella - Columbia MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A61K 31485

US Classification:

514289

Abstract:

It has been discovered that certain (+)-3-substituted-N-alkylmorphinans are ffective anticonvulsant and neuroprotective agents. Novel compounds having these biological properties are presented in a method of use for preventing, treating or controlling convulsions in mammals having a need for such treatment. The compounds do not lead to dependency, have low toxicity, and provide effective anticonvulsant or neuroprotective treatment with little or no behavioral detriment to the recipient. A number of pharmacological formulations and methods of administering compounds of the invention are suitable for anticonvulsive or neuroprotective treatments.

US Patent:

53310101, Jul 19, 1994

Filed:

Jun 5, 1991

Appl. No.:

7/715082

Inventors:

Amy H. Newman - Silver Spring MD
Silvia N. Calderon - Silver Spring MD
Frank C. Tortella - Columbia MD

Assignee:

The United States of America as represented by the Secretary of the Army - Washington DC

International Classification:

A01N 3718
A01N 3302
C07C23300

US Classification:

514617

Abstract:

The compounds belong to the class of non-narcotic, non-opiate derivatives the 1-phenylalkanecarboxylic acid basic structure useful as anticonvulsant and neuroprotective agents. The compounds include novel derivatives as well as previously published species. Methods for controlling convulsions in a variety of pharmaceutical formulations and modalities are also provided.

US Patent:

56682859, Sep 16, 1997

Filed:

Mar 12, 1992

Appl. No.:

7/851672

Inventors:

Kenner C. Rice - Bethesda MD
Amy H. Newman - Silver Spring MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C07D48902

US Classification:

546 44

Abstract:

The invention involves a method of making key intermediates useful in the synthesis of many opiate narcotics and antagonists and agonists; and the non-opiate enantiomers thereof which have potent antitussive properties. The synthesis starts from either the natural or unnatural enantiomer of nordihydrocodeinone and produces 8, 14-dihydronorthebaine, the diketal of 7-bromonordihydrocodeinone, northebaine, norcodeinone diketal and 14-hydroxynorcodeinone intermediates without the necessity of leaving the N-nor structure. The syntheses have fewer steps than previous methods, and also have high yields.