Amy E Tapper

US Patent:

20100137383, Jun 3, 2010

Filed:

Jul 14, 2009

Appl. No.:

12/502559

Inventors:

Amy E. Tapper - Boston MA, US
Stephan D. Parent - West Lafayette IN, US
Patricia Andres - West Lafayette IN, US
Jason A. Hanko - West Lafayette IN, US
Huamin Zhang - West Lafayette IN, US

Assignee:

FERROKIN BIOSCIENCES, INC. - San Carlos CA

International Classification:

A61K 31/426
C07D 277/12
A61P 43/00
A61P 7/06

US Classification:

514365, 548201

Abstract:

Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

US Patent:

20110160257, Jun 30, 2011

Filed:

Mar 7, 2011

Appl. No.:

13/042193

Inventors:

Amy E. Tapper - Boston MA, US
Stephan D. Parent - West Lafayette IN, US
Patricia Andres - West Lafayette IN, US
Jason A. Hanko - West Lafayette IN, US
Huamin Zhang - West Lafayette IN, US

Assignee:

FERROKIN BIOSCIENCES, INC. - San Carlos CA

International Classification:

A61K 31/426
C07D 277/12
A61P 3/00
A61P 43/00
A61P 7/00

US Classification:

514365, 548201

Abstract:

Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

US Patent:

20120202857, Aug 9, 2012

Filed:

Aug 4, 2011

Appl. No.:

13/198287

Inventors:

Amy E. Tapper - Boston MA, US
Stephan D. Parent - West Lafayette IN, US
Patricia Andres - West Lafayette IN, US
Jason A. Hanko - West Lafayette IN, US
Huamin Zhang - West Lafayette IN, US

Assignee:

FERROKIN BIOSCIENCES, INC. - San Carlos CA

International Classification:

A61K 31/426
A61P 7/06
A61P 31/14
A61P 3/10
A61P 1/16
A61P 39/04
A61P 35/02

US Classification:

514365

Abstract:

Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

US Patent:

20120270911, Oct 25, 2012

Filed:

Oct 6, 2011

Appl. No.:

13/267285

Inventors:

Amy E. Tapper - Boston MA, US
Stephan D. Parent - West Lafayette IN, US
Patricia Andres - West Lafayette IN, US
Jason A. Hanko - West Lafayette IN, US
Huamin Zhang - West Lafayette IN, US

Assignee:

FERROKIN BIOSCIENCES, INC. - San Carlos CA

International Classification:

C07D 277/10
A61P 39/04
A61K 31/426

US Classification:

514365, 548201

Abstract:

Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

US Patent:

20210163522, Jun 3, 2021

Filed:

Dec 2, 2020

Appl. No.:

17/109970

Inventors:

- Baltimore MD, US
Amanda HILL - Cambridge, GB
Kate WITTERING - Cambridge, GB
Amy TAPPER - Boston MA, US
Nikola KALUDOV - Deale MD, US

International Classification:

C07H 17/08
A61K 45/06
A61P 33/06

Abstract:

Disclosed herein are new salts and polymorphs of cethromycin for the treatment of diseases due to infection by bacteria and certain protozoans, including, for example, malaria, Babesosis, Toxoplasmosis, diarrheal disease, respiratory disease, sexually transmitted bacterial infections, and some bioterror bacteria, including, for example, plague, tularemia and post-inhalation anthrax. Also disclosed herein are new salts and polymorphs of cethromycin for the treatment of inflammatory diseases, including, for example, pelvic inflammatory disease, and peptic ulcer disease.

US Patent:

20200283397, Sep 10, 2020

Filed:

Nov 1, 2019

Appl. No.:

16/672083

Inventors:

- San Carlos CA, US
John M. MCCALL - Boca Grande FL, US
Michael CLARE - Skokie IL, US
Cassandra CELATKA - Hull MD, US
Amy E. TAPPER - Boston MA, US

International Classification:

C07D 249/06
C07C 309/30
A61K 9/00
A61K 31/496
C07D 239/26
A61K 31/506
C07D 295/192
A61K 31/495
C07D 279/12
A61K 31/54
C07D 205/04
A61K 31/397
C07D 295/26
C07D 215/54
C07C 53/18
C07D 231/12
C07D 263/32
A61K 31/541
C07B 59/00
C07D 403/12
A61K 31/4192
C07D 401/12
A61K 31/454
C07D 249/08
A61K 31/4196
C07D 211/66
A61K 31/445
C07D 239/42
C07D 491/107
C07D 413/12
A61K 31/5377
C07D 498/08
A61K 31/5383
C07D 471/10
A61K 31/435
C07D 401/04
A61K 31/41
C07D 487/04
A61K 31/4162
C07D 487/08
A61K 31/4995
A61K 31/551
C07D 237/08
A61K 31/501
A61K 9/16
A61K 9/48
A61K 45/06
A61P 29/00
A61P 35/00
A61P 35/02
A61P 43/00

Abstract:

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

US Patent:

20180312474, Nov 1, 2018

Filed:

Apr 12, 2018

Appl. No.:

15/952073

Inventors:

- San Carlos CA, US
John M. MCCALL - Boca Grande FL, US
Michael CLARE - Skokie IL, US
Cassandra CELATKA - Hull MD, US
Amy E. TAPPER - Boston MA, US

International Classification:

C07D 249/06
A61K 31/501
C07D 237/08
A61K 31/551
A61K 31/4995
C07D 487/08
A61K 31/4162
C07D 487/04
A61K 31/41
C07D 401/04
A61K 31/435
C07D 471/10
A61K 31/5383
C07D 498/08
A61K 31/5377
C07D 413/12
C07D 491/107
C07D 239/42
A61K 31/445
C07D 211/66
A61K 31/4196
C07D 249/08
A61K 31/454
C07D 401/12
A61K 31/4192
C07D 403/12
A61K 31/541
C07D 263/32
C07D 231/12
C07D 215/54
C07D 295/26
A61K 31/397
C07D 205/04
A61K 31/54
C07D 279/12
A61K 31/495
C07D 295/192
A61K 31/506
C07D 239/26
A61K 31/496
C07C 309/30
C07B 59/00
C07C 53/18
A61K 9/00
A61P 43/00
A61P 35/02
A61P 35/00
A61P 29/00
A61K 45/06
A61K 9/48
A61K 9/16

Abstract:

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

US Patent:

20160237043, Aug 18, 2016

Filed:

Feb 12, 2016

Appl. No.:

15/043121

Inventors:

- San Carlos CA, US
John M. McCall - Boca Grande FL, US
Michael Clare - Skokie IL, US
Cassandra Celatka - Hull MD, US
Amy E. Tapper - Boston MA, US

International Classification:

C07D 249/06
A61K 9/00
A61K 31/496
C07D 239/26
A61K 31/506
C07D 295/192
A61K 31/495
C07D 279/12
A61K 31/54
C07D 205/04
A61K 31/397
C07D 295/26
C07D 215/54
C07C 53/18
C07D 231/12
C07D 263/32
A61K 31/541
C07B 59/00
C07D 403/12
A61K 31/4192
C07D 401/12
A61K 31/454
C07D 249/08
A61K 31/4196
C07D 211/66
A61K 31/445
C07D 239/42
C07D 491/107
C07D 413/12
A61K 31/5377
C07D 498/08
A61K 31/5383
C07D 471/10
A61K 31/435
C07D 401/04
A61K 31/41
C07D 487/04
A61K 31/4162
C07D 487/08
A61K 31/4995
A61K 31/551
C07D 237/08
A61K 31/501
C07C 309/30

Abstract:

Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.