Amy C Wang

US Patent:

6454759, Sep 24, 2002

Filed:

Feb 28, 2001

Appl. No.:

09/795384

Inventors:

Peter A. Krulevitch - Pleasanton CA
Amy W. Wang - Oakland CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 922

US Classification:

6048911, 6048922, 424423

Abstract:

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

US Patent:

6480730, Nov 12, 2002

Filed:

Dec 20, 2000

Appl. No.:

09/742775

Inventors:

Christopher B. Darrow - Pleasanton CA
Stephen M. Lane - Oakland CA
Abraham P. Lee - Walnut Creek CA
Amy W. Wang - Berkeley CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 505

US Classification:

600347, 600345

Abstract:

An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e. g. , frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.

US Patent:

6576459, Jun 10, 2003

Filed:

Mar 23, 2001

Appl. No.:

09/815624

Inventors:

Robin R. Miles - Danville CA
Amy W. Wang - Oakland CA
Christopher K. Fuller - Livermore CA
Asuncion V. Lemoff - Union City CA
Kerry A. Bettencourt - Dublin CA
June Yu - Livermore CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12M 136

US Classification:

4352865, 4352867, 4352872, 4352885, 4352887, 435810, 435962

Abstract:

A sample preparation and analysis device which incorporates both immunoassays and PCR assays in one compact, field-portable microchip. The device provides new capabilities in fluid and particle control which allows the building of a fluidic chip with no moving parts, thus decreasing fabrication cost and increasing the robustness of the device. The device can operate in a true continuous (not batch) mode. The device incorporates magnetohydrodynamic (MHD) pumps to move the fluid through the system, acoustic mixing and fractionation, dielectropheretic (DEP) sample concentration and purification, and on-chip optical detection capabilities.

US Patent:

6866759, Mar 15, 2005

Filed:

Dec 13, 2000

Appl. No.:

09/738462

Inventors:

Robin R. Miles - Danville CA, US
Amy Wei-Yun Wang - Oakland CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N027/447
G01N027/453

US Classification:

204457, 204458, 204608, 204609, 204451, 204601, 204643, 204547, 435 6, 4352872

Abstract:

A fluidic channel patterned with a series of thin-film electrodes makes it possible to move and concentrate DNA in a fluid passing through the fluidic channel. The DNA has an inherent negative charge and by applying a voltage between adjacent electrodes the DNA is caused to move. By using a series of electrodes, when one electrode voltage or charge is made negative with respect to adjacent electrodes, the DNA is repelled away from this electrode and attached to a positive charged electrode of the series. By sequentially making the next electrode of the series negative, the DNA can be moved to and concentrated over the remaining positive electrodes.

US Patent:

7601286, Oct 13, 2009

Filed:

Mar 26, 2002

Appl. No.:

10/107933

Inventors:

William Benett - Livermore CA, US
Peter Krulevitch - Pleasanton CA, US
Mariam Maghribi - Livermore CA, US
Julie Hamilton - Tracy CA, US
Klint Rose - Boston MA, US
Amy W. Wang - Oakland CA, US

Assignee:

Lawrence Livermore National Security, LLC - Livermore CA

International Classification:

B29C 33/76

US Classification:

264221, 264317

Abstract:

A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure.

US Patent:

20110077478, Mar 31, 2011

Filed:

Nov 9, 2010

Appl. No.:

12/942246

Inventors:

Dominique Freeman - La Honda CA, US
Ajay Deshmukh - San Francisco CA, US
Jason Hegener - San Francisco CA, US
Thomas Shoup - Los Altos CA, US
Brent Eaton - Mountain View CA, US
Joshua Molho - Oakland CA, US
Amy Wang - Hayward CA, US
Jeffrey Perry - Sunnyvale CA, US

International Classification:

A61B 5/157
A61B 5/151

US Classification:

600309, 600583

Abstract:

A body fluid sampling device includes a housing, a penetrating member positioned in the housing and a test strip. A compliant front end is coupled to the housing. The compliant front-end includes a rigid member with an interior aperture to receive the body fluid from a wound site.

US Patent:

62019805, Mar 13, 2001

Filed:

Oct 5, 1998

Appl. No.:

9/166236

Inventors:

Christopher B. Darrow - Pleasanton CA
Joe H. Satcher - Modesto CA
Stephen M. Lane - Oakland CA
Abraham P. Lee - Walnut Creek CA
Amy W. Wang - Berkeley CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61B 505

US Classification:

600347

Abstract:

An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e. g. , frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.