Amy Darlene Williams

US Patent:

7785827, Aug 31, 2010

Filed:

Sep 20, 2002

Appl. No.:

10/251648

Inventors:

Susan A. Martinis - Houston TX, US
James M. Briggs - Katy TX, US
Richard S. Mursinna - Houston TX, US
Keun Woo Lee - Houston TX, US
Tommie L. Lincecum - Houston TX, US
Amy M. Williams - Houston TX, US
Yuxin Zhai - Houston TX, US

Assignee:

University of Houston System - Houston TX

International Classification:

C07K 14/47
C07H 21/04
C12P 21/06

US Classification:

435 691, 435183, 4353201, 536 235

Abstract:

A method and composition for tRNA synthetases that activate and aminoacylate nonstandard and noncognate amino acids to tRNA adaptor molecules is described that can be used to generate custom designed protein products for uses in medicinal, therapeutic, diagnostic, biotechnology, engineering, and spectroscopy applications. Some tRNA synthetases naturally misactivate and misaminoacylate noncognate amino acids. Many of these tRNA synthetases, including but not limited to leucyl-, isoleucyl-, and valyl-tRNA synthetases, have evolved proofreading and editing mechanisms to correct these mistakes. Inactivation of the enzyme's editing activity allows and facilitates production and accumulation of tRNAs that are misaminoacylated with nonstandard and noncognate amino acids. These misaminoacylated tRNAs can be used to introduce novel amino acids into proteins.

US Patent:

20080091005, Apr 17, 2008

Filed:

Jul 20, 2007

Appl. No.:

11/781160

Inventors:

Hongyi Wang - Houston TX, US
Xiaolian Gao - Houston TX, US
Peilin Yu - Houston TX, US
Mitsu Reddy - Pearland TX, US
Susan Hardin - College Station TX, US
Tommie Lincecum - Houston TX, US
Amy Williams - Houston TX, US
Norha Deluge - Houston TX, US
Yuri Belosludtsev - The weedlands TX, US
Steven Menchen - Fremont CA, US
Joe Lam - Castro Valley CA, US

Assignee:

VISIGEN BIOTECHNOLOGIES, INC. - Houston TX
APPLIED BIOSYSTEMS - Foster City CA

International Classification:

C07H 21/04

US Classification:

536026600

Abstract:

Modified nucleotides are disclosed for use in single molecule sequencing, methods for making the modified nucleotides and method for using the modified nucleotides. Linkers for making the modified nucleotide are also disclosed.

US Patent:

20090186343, Jul 23, 2009

Filed:

Feb 21, 2008

Appl. No.:

12/035352

Inventors:

Hongyi Wang - Houston TX, US
Norha Deluge - Pearland TX, US
Kristi Kincaid - Houston TX, US
Yuri Belosludtsev - The Woodlands TX, US
Tommie Lincecum, JR. - Houston TX, US
Amy Williams - Houston TX, US
Amy Bryant - League City TX, US
Ming Fa - Pearland TX, US
Benjamin Stevens - Houston TX, US
Susan H. Hardin - College Station TX, US

Assignee:

VISIGEN BIOTECHNOLOGIES, INC. - Houston TX

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 6, 536124

Abstract:

A novel and efficient single pot synthetic schemes are disclosed for preparing modified nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs. The novel method is used to prepare nucleotides, nucleotide analogs, nucleotide polyphosphates, and nucleotide polyphosphate analogs having non-persistent or persistent and non-persistent modifications. Novel biomolecular reactions are also disclosed using the novel modified biomolecules disclosed herein.

Address:

7777 Greenbriar St APT 2091, Houston, TX 77030

Phone:

(713)3839858

VIN:

1NXBR32E27Z912121

Make:

TOYOTA

Model:

COROLLA

Year:

2007