Amy Loo Wong

US Patent:

20040102406, May 27, 2004

Filed:

Jun 12, 2003

Appl. No.:

10/312752

Inventors:

Pnina Brodt - Montreal, CA
John Nip - Brooklyn NY, US
Amy Wong - New York NY, US

International Classification:

A61K048/00
C07H021/04

US Classification:

514/044000, 536/023200

Abstract:

The present invention relates to a novel class of inhibitors of angiogenesis and/or metastasis that targets cell adhesion molecules, and more particularly to antisense phosphorothioate oligonucleotides directed to a subunit of an integrin vitronectin receptor to inhibit angiogenesis and/or metastasis. There is provided an antisense phosphorothioate oligonucleotide directed to one of a , and subunit of an integrin vitronectin receptor. The antisense phosphorothioate oligonucleotide blocks synthesis of the integrin vitronectin receptor on a target cell, thereby inhibiting angiogenesis and/or metastasis. There is provided a method for blocking angiogenesis and/or metastasis in a patient, comprising delivering an efficient amount of such an antisense phosphorothioate oligonucleotide to the target cell of the patient, thereby blocking synthesis of the integrin vitronectin receptor on the target cell and blocking angiogenesis and/or metastasis.

US Patent:

52000290, Apr 6, 1993

Filed:

Dec 4, 1991

Appl. No.:

7/803290

Inventors:

Allan J. Bruce - Westfield NJ
Joseph Shmulovich - Murray Hill NJ
Amy Wong - Whitestone NY

Assignee:

AT&T Bell Laboratories - Murray Hill NJ

International Classification:

C03C 1500

US Classification:

156657

Abstract:

An active optical device comprises a glass, waveguiding structure disposed on a substantially planar principal surface of a substrate. The structure includes a silica-based, erbium-doped active core. The active core has an erbium-to-silicon atomic ratio of at least about 0. 01, an absolute erbium concentration of at least about 1. 4. times. 10. sup. 20 atoms per cubic centimeter, and a radiative lifetime of the erbium lasing level of at least about 7 milliseconds. Also disclosed is a method for forming an active optical device, including the step of depositing an erbium-doped active core by sputtering.