An Thanh Tran

US Patent:

6448382, Sep 10, 2002

Filed:

Apr 14, 2000

Appl. No.:

09/549290

Inventors:

Michael Kunitani - Corte Madera CA
An D. Tran - Moraga CA
Hugh Parker - Oakland CA

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C07K 1449

US Classification:

530416, 530399, 530412, 435 695, 43525421, 435183, 4241851

Abstract:

Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of these proteins is achieved using TSK sulfopropyl cation exchange chromatography and reverse phase high performance liquid chromatography. A reverse charged capillary zone electrophoresis method enables quantification of substantially pure isoforms of these proteins resulting from endoproteolytic post-translational modifications. Compositions of the invention are substantially purified isoforms of secreted PDGF proteins having structural heterogeneity, more particularly purified intact, single-clipped, and double-clipped isoforms of recombinant PDGF-BB. Pharmaceutical compositions comprising at least one of these substantially purified recombinant PDGF isoforms and methods for their use in promoting wound healing are also provided.

US Patent:

7084262, Aug 1, 2006

Filed:

Jul 26, 2002

Appl. No.:

10/205693

Inventors:

Michael Kunitani - Corte Madera CA, US
An D. Tran - Moraga CA, US
Hugh Parker - Oakland CA, US

Assignee:

Chiron Corporation - Emeryville CA

International Classification:

C07K 14/49
A61K 38/18

US Classification:

530412, 530416, 530399, 435 691, 43525421

Abstract:

Methods for improving purification and quantification of platelet derived growth factor (PDGF) proteins having structural heterogeneity are provided. Preparation of substantially pure isoforms of these proteins is achieved using TSK sulfopropyl cation exchange chromatography and reverse phase high performance liquid chromatography. A reverse charged capillary zone electrophoresis method enables quantification of substantially pure isoforms of these proteins resulting from endoproteolytic post-translational modifications. Compositions of the invention are substantially purified isoforms of secreted PDGF proteins having structural heterogeneity, more particularly purified intact, single-clipped, and double-clipped isoforms of recombinant PDGF-BB. Pharmaceutical compositions comprising at least one of these substantially purified recombinant PDGF isoforms and methods for their use in promoting wound healing are also provided.

US Patent:

D538836, Mar 20, 2007

Filed:

Feb 11, 2005

Appl. No.:

29/223353

Inventors:

Hans Karsten Moritz - Foothill Ranch CA, US
Colin Baden - Irvine CA, US
Eric Daniels - Dana Point CA, US
An Tran - Austin TX, US

Assignee:

Oakley, Inc. - Foothill Ranch CA

International Classification:

1606

US Classification:

D16330

US Patent:

7874669, Jan 25, 2011

Filed:

Feb 27, 2009

Appl. No.:

12/395500

Inventors:

Hans Karsten Moritz - Foothill Ranch CA, US
Mark Bu - Aliso Viejo CA, US
Errol Tazbaz - Mission Viejo CA, US
An Tran - Austin TX, US

Assignee:

Oakley, Inc. - Foothill Ranch CA

International Classification:

G02C 5/14

US Classification:

351119, 351 52, 351158

Abstract:

An eyeglass component mounting system is provided that can comprise a frame and at least a first ear stem. The first ear stem extends rearwardly from the frame and defines an anterior end and a posterior end. The anterior end of the first ear stem can be hingedly coupled to the frame such that the first ear stem can be pivotably movable between a stowed position and a deployed position. The first ear stem can comprise a mounting area configured to receive an eyewear component thereon such that the eyewear component can be removed or seated onto the mounting area when the first ear stem is in the stowed position and such that the eyewear component is retained on the mounting area when the first ear stem is in the deployed position.

US Patent:

7954942, Jun 7, 2011

Filed:

Jul 3, 2009

Appl. No.:

12/497632

Inventors:

Ryan Calilung - Irvine CA, US
David Ginther - Ladera Ranch CA, US
Hans Moritz - Foothill Ranch CA, US
Carlos Reyes - Rancho Santa Margarita CA, US
Ryan Saylor - Mission Viejo CA, US
An Tran - Austin TX, US

Assignee:

Oakley, Inc. - Foothill Ranch CA

International Classification:

G02C 1/08

US Classification:

351 98, 351 92, 351137

Abstract:

Various embodiments of an eyeglass and eyeglass system are provided that can maintain the geometric and optical quality of a lens supported by the eyeglass. The eyeglass can comprise a frame, a support member carried by the frame, and a lens mounting area or groove extending at least partially along at least one of the frame and the support member. The support member can be pivoted, moved, or deflected relative to the frame between a retaining position and an open position. In the open position, the lens can be seated within the lens mounting area. In the retaining position, the support member and the frame retain the lens without exerting deformative forces on the lens. Accordingly, the as-molded geometric and optical qualities of the lens can be preserved.

US Patent:

8123351, Feb 28, 2012

Filed:

Jan 6, 2011

Appl. No.:

12/985910

Inventors:

Hans Karsten Moritz - Foothill Ranch CA, US
Mark Bu - Aliso Viejo CA, US
Errol Tazbaz - Mission Viejo CA, US
An Tran - Austin TX, US

Assignee:

Oakley, Inc. - Foothill Ranch CA

International Classification:

G02C 5/14

US Classification:

351119, 351 52, 351158

Abstract:

An eyeglass component mounting system is provided that can comprise a frame and at least a first ear stem. The first ear stem extends rearwardly from the frame and defines an anterior end and a posterior end. The anterior end of the first ear stem can be hingedly coupled to the frame such that the first ear stem can be pivotably movable between a stowed position and a deployed position. The first ear stem can comprise a mounting area configured to receive an eyewear component thereon such that the eyewear component can be removed or seated onto the mounting area when the first ear stem is in the stowed position and such that the eyewear component is retained on the mounting area when the first ear stem is in the deployed position.

US Patent:

8262219, Sep 11, 2012

Filed:

Jan 7, 2011

Appl. No.:

12/986971

Inventors:

Duane J. Lee - Orange CA, US
Kevin K. Grant - Lake Forest CA, US
An Tran - Austin TX, US

Assignee:

Oakley, Inc. - Foothill Ranch CA

International Classification:

G02C 5/16

US Classification:

351122, 351123

Abstract:

An earstem for eyeglasses is provided that can incorporate an interchangeable elastomeric traction member disposed in a recessed seat which extends along a length of the earstem to provide a contact area between the earstem and the head. The traction member can be disposed along the bottom portion of the earstem and/or around the periphery of the earstem. The traction device can be detachably coupled to the earstem so that the traction device can be exchanged to accommodate different needs or situations.

US Patent:

8408695, Apr 2, 2013

Filed:

Jun 6, 2011

Appl. No.:

13/154209

Inventors:

Ryan Calilung - Irvine CA, US
David Ginther - Ladera Ranch CA, US
Hans Moritz - Foothill Ranch CA, US
Carlos Reyes - Rancho Santa Margarita CA, US
Ryan Saylor - Mission Viejo CA, US
An Tran - Austin TX, US

Assignee:

Oakley, Inc. - Foothill Ranch CA

International Classification:

G02C 1/08

US Classification:

351 98, 351 92, 351137

Abstract:

Various embodiments of an eyeglass and eyeglass system are provided that can maintain the geometric and optical quality of a lens supported by the eyeglass. The eyeglass can comprise a frame, a support member carried by the frame, and a lens mounting area or groove extending at least partially along at least one of the frame and the support member. The support member can be pivoted, moved, or deflected relative to the frame between a retaining position and an open position. In the open position, the lens can be seated within the lens mounting area. In the retaining position, the support member and the frame retain the lens without exerting deformative forces on the lens. Accordingly, the as-molded geometric and optical qualities of the lens can be preserved.