Anagha A Bhakay

US Patent:

20130295190, Nov 7, 2013

Filed:

Mar 14, 2013

Appl. No.:

13/829948

Inventors:

Ecevit Bilgili - Woodbridge NJ, US
Rajesh Dave - Princeton NJ, US
Anagha Bhakay - Harrison NJ, US
Mohammad Azad - Newark NJ, US

Assignee:

New Jersey Institute of Technology - Newark NJ

International Classification:

A61J 3/00

US Classification:

424499, 427 216, 424489, 514462, 514543, 241 16

Abstract:

The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g., micro-particle formulations) and enhance the recovery of the nanoparticles of active agents during aqueous re-dispersion and their dissolution rate in vitro and in vivo.

US Patent:

20210161867, Jun 3, 2021

Filed:

Dec 11, 2018

Appl. No.:

16/769509

Inventors:

- Madison NJ, US
Anagha Avinash Bhakay - Fanwood NJ, US

Assignee:

Intervet Inc. - Madison NJ

International Classification:

A61K 31/42
A61K 9/00
A61K 9/16
A61K 9/50
A61K 9/20
A61K 47/02
A61K 47/12
A61K 47/10

Abstract:

An implant for the control of parasites in livestock comprising an isoxazoline compound of Formula (I) or salt or solvate thereof, wherein the implant comprises one or more pellets each of which comprises the isoxaxoline compound and a pharmaceutically acceptable excipient and a method of preventing or treating a parasite infestation using the same.

US Patent:

20160346209, Dec 1, 2016

Filed:

Aug 12, 2016

Appl. No.:

15/235397

Inventors:

- Newark NJ, US
Rajesh Dave - Princeton NJ, US
Anagha Bhakay - Harrison NJ, US
Mohammad Azad - Newark NJ, US

Assignee:

New Jersey Institute of Technology - Newark NJ

International Classification:

A61K 9/14
B05D 7/24
A61K 31/343
A61J 3/02
A61K 31/216

Abstract:

The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g., micro-particle formulations) and enhance the recovery of the nanoparticles of active agents during aqueous re-dispersion and their dissolution rate in vitro and in vivo.

US Patent:

20160022599, Jan 28, 2016

Filed:

Mar 17, 2014

Appl. No.:

14/777191

Inventors:

- Newark NJ, US
Ramani Susarla - Broad View Heights OH, US
Boris Khusid - New Providence NJ, US
Anagha A. Bhakay - Philadelphia PA, US
Ecevit A. Bilgili - Woodbridge NJ, US
Fernando Muzzio - Pennington NJ, US

Assignee:

NEW JERSEY INSTITUTE OF TECHNOLOGY - Newark NJ

International Classification:

A61K 9/70
A61K 47/38
B29C 39/14
A61K 31/216
B29C 39/00
A61K 31/343
A61K 47/32

Abstract:

The present disclosure provides improved stripfilm based pharmaceutical products (e.g., for enhancing dissolution and bioavailability). More particularly, the present disclosure provides improved systems/methods for fabricating stripfilm based pharmaceutical products by utilizing higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products. Exemplary systems/methods advantageously use high viscosity, bio-compatible polymeric precursors, (optional use of surface modified drug powders), and convective drying for fabrication of thin films loaded with nano and/or micro sized particles of poorly water-soluble active pharmaceutical ingredients (APIs) to achieve improved active content uniformity and very fast dissolution from poorly water soluble actives, while accomplishing fast drying during the fabrication process. The present disclosure provides for the fast drying (e.g., via low temperature forced convection) of biocompatible polymer films loaded with poorly water-soluble drug nano-particles.