Andreas W Schirmer

US Patent:

6624302, Sep 23, 2003

Filed:

Dec 27, 2002

Appl. No.:

10/331047

Inventors:

Daniel Chu - Santa Clara CA
Maria Fardis - San Carlos CA
Chaitan Khosla - Palo Alto CA
Christopher Reeves - Orinda CA
Daniel Santi - San Francisco CA
Andreas Schirmer - Hayward CA

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C07D49816

US Classification:

540456

Abstract:

The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a âmacrolidesâ or âmacrolactonesâ) that include as part of their structure and bind to a FK binding protein wherein R and R are each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of R and R is hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.

US Patent:

7189549, Mar 13, 2007

Filed:

Jun 13, 2003

Appl. No.:

10/461194

Inventors:

Richard C. Hutchinson - San Mateo CA, US
Ralph C. Reid - San Rafael CA, US
Zhihao Hu - Castro Valley CA, US
Andreas Rascher - San Francisco CA, US
Andreas Schirmer - Hayward CA, US
Robert McDaniel - Palo Alto CA, US

Assignee:

Kosan Biosciences, Inc. - Hayward CA

International Classification:

C12N 9/02
C12N 9/10
C12N 15/53
C12N 15/54
C12N 15/74

US Classification:

435190, 435193, 435 697, 43525235, 4353201, 536 232

Abstract:

The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.

US Patent:

7671190, Mar 2, 2010

Filed:

Jan 16, 2007

Appl. No.:

11/654485

Inventors:

Richard C. Hutchinson - San Mateo CA, US
Ralph C. Reid - San Rafael CA, US
Zhihao Hu - Castro Valley CA, US
Andreas Rascher - San Francisco CA, US
Andreas Schirmer - Hayward CA, US
Robert McDaniel - Palo Alto CA, US

Assignee:

Kosan Biosciences Incorporation - Princeton NJ

International Classification:

C12N 15/53
C12N 15/74
C12N 15/76
C12N 15/31
C12N 9/06

US Classification:

536 232, 435189, 435 691, 4352523, 43525235, 4353201, 536 2432

Abstract:

The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains of geldanamycin and herbimycin polyketide synthases, polynucleotides that encode such enzymes, and to host cells in which such encoding polynucleotides can be advantageously expressed.

US Patent:

8183028, May 22, 2012

Filed:

Dec 22, 2008

Appl. No.:

12/673752

Inventors:

Murtaza Alibhai - Austin TX, US
Mathew Rude - San Francisco CA, US
Andreas Schirmer - Fremont CA, US

Assignee:

LS9, Inc. - South San Francisco CA

International Classification:

C12N 1/20
C12P 5/02

US Classification:

4352523, 435167, 435232, 536 232

Abstract:

Compositions and methods for producing olefins are described herein. The olefins can be used to produced biofuels.

US Patent:

8268599, Sep 18, 2012

Filed:

Feb 22, 2010

Appl. No.:

12/710238

Inventors:

Andreas Schirmer - South San Francisco CA, US
Mathew Rude - South San Francisco CA, US
Shane Brubaker - Oakland CA, US

Assignee:

LS9, Inc. - South San Francisco CA

International Classification:

C12P 7/24

US Classification:

435147, 435 71, 435 691, 4353201, 530350

Abstract:

Compositions and methods for producing hydrocarbons such as aldehydes, alkanes, and alkenes are described herein. Certain hydrocarbons can be used in biofuels.

US Patent:

8323924, Dec 4, 2012

Filed:

Feb 22, 2010

Appl. No.:

12/710237

Inventors:

Andreas Schirmer - South San Francisco CA, US
Mathew Rude - South San Francisco CA, US
Shane Brubaker - Oakland CA, US

Assignee:

LS9, Inc. - South San Francisco CA

International Classification:

C12P 1/00

US Classification:

435 41, 435183, 435189, 4352523, 536 232

Abstract:

Compositions and methods for producing aldehydes, alkanes, and alkenes are described herein. The aldehydes, alkanes, and alkenes can be used in biofuels.

US Patent:

8530221, Sep 10, 2013

Filed:

May 10, 2011

Appl. No.:

13/104819

Inventors:

Zhihao Hu - South San Francisco CA, US
Grace J. Lee - South San Francisco CA, US
Andreas W. Schirmer - South San Francisco CA, US
Kseniya Zakharyevich - San Francisco CA, US
Derek L. Greenfield - South San Francisco CA, US
Tarah S. Baron - South San Francisco CA, US
Kevin Holden - South San Francisco CA, US

Assignee:

LS9, Inc. - South San Francisco CA

International Classification:

C12N 1/00
C12N 1/20
C12P 1/00

US Classification:

435243, 4352523, 435 41

Abstract:

Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of making branched fatty acid derivatives using the recombinant microbial cells.

US Patent:

20020065295, May 30, 2002

Filed:

May 10, 2001

Appl. No.:

09/853306

Inventors:

Daniel Chu - Santa Clara CA, US
Maria Fardis - San Carlos CA, US
Chaitan Khosla - Palo Alto CA, US
Christopher Reeves - Orinda CA, US
Daniel Santi - San Francisco CA, US
Andreas Schirmer - Hayward CA, US

International Classification:

C07D487/04
A61K031/4745

US Classification:

514/291000, 540/456000

Abstract:

The present invention relates to novel polyketides, host cells that produce the novel compounds, and methods fort their use. The compounds of the present invention are cyclic polyketides (also referred to as a “macrolides” or “macrolactones”) that include as part of their structure and bind to a FK binding protein wherein Rand Rare each selected from the group consisting of hydrogen, methyl, ethyl, and methoxy, provided that at least one of Rand Ris hydrogen, methyl, or ethyl. As will be explained in greater detail below, the compounds of the present invention have properties such as favorable P450 enzyme activity profiles that are desirable for use of these compounds as drugs.