Andrew S Cheng

US Patent:

8329447, Dec 11, 2012

Filed:

Dec 9, 2009

Appl. No.:

12/634504

Inventors:

Yang Liu - Mountain View CA, US
Rosa R. Yu - Sunnyvale CA, US
Andrew Cheng - San Jose CA, US
Qing Xia - Santa Clara CA, US
Qiang Xu - Cupertino CA, US

Assignee:

Osel, Inc. - Santa Clara CA

International Classification:

C12N 1/20
A01N 63/00

US Classification:

4352529, 424 9345

Abstract:

The invention provides a naturally occurring strain of with advantageous characteristics. The strain colonizes mucosal surfaces, particularly vaginal surfaces. The strain is also capable of rapid growth in a number of conditions and is highly viable after desiccation. Moreover, the strain is capable of preventing and reducing pathogenic infection of vaginal mucosa.

US Patent:

57064539, Jan 6, 1998

Filed:

Feb 6, 1995

Appl. No.:

8/384016

Inventors:

Andrew Y. Cheng - San Jose CA

International Classification:

G06F 1500

US Classification:

395347

Abstract:

A configuration management system which generates and updates its own real-time dynamic database for representing a system configuration. The configuration management system includes an user interface for receiving user input of free-hand graphic drawings representing system configuration changes. The configuration management system further includes an interactive graphic interpretive and linking actuator which employs the user input of free-hand graphic drawings representing the system configuration changes for linking to sections of the database corresponding to the user input of configuration changes and updating data stored therein thus representing a new system configuration updated by the user input of the configuration changes. The user interface future includes a dialog box for receiving system parameters relating to the user input of free-hand graphic drawings representing the system configuration changes. The interactive graphic interpretive and linking actuator further employs the system parameters received from the dialog box for updating the database.

US Patent:

20230050043, Feb 16, 2023

Filed:

Dec 22, 2020

Appl. No.:

17/787880

Inventors:

- San Francisco CA, US
Nicholas B. Justice - SE Atlanta GA, US
Magdalena K. Stoeva - Oakland CA, US
John S. Eid - San Francisco CA, US
Julia N. Myers - San Francisco CA, US
Andrew T. Cheng - San Francisco CA, US
Moe Brandi - San Francisco CA, US
Paul McMurdie - San Francisco CA, US
James H. Bullard - San Francisco CA, US

International Classification:

A61K 35/741
A61K 31/733
A61K 35/745
A61K 35/744
A61P 1/00
A61K 35/742
A23L 33/135
A23L 33/21

Abstract:

The disclosure provides microbial compositions (e.g., compositions comprising one or more microbes or protein components thereof), that can be administered to subjects to confer beneficial effects. Disclosed compositions can, for example, be useful in reducing visceral hypersensitivity, or pain in response to colorectal distension.

US Patent:

20210213078, Jul 15, 2021

Filed:

Mar 23, 2021

Appl. No.:

17/210078

Inventors:

- San Francisco CA, US
Colleen CUTCLIFFE - Menlo Park CA, US
Orville KOLTERMAN - San Francisco CA, US
Fanny PERRAUDEAU - San Francisco CA, US
James BULLARD - San Francisco CA, US
Paul MCMURDIE - San Francisco CA, US
Andrew CHENG - San Francisco CA, US
Marcus SCHICKLBERGER - San Francisco CA, US
Nicholas JUSTICE - San Francisco CA, US

International Classification:

A61K 35/747
A61K 9/00
A61K 35/742
A61K 35/741
A61K 35/745
A61K 35/744
A61K 31/155
A61P 3/10

Abstract:

Administering a composition comprising at least one mucin-regulating and at least one butyrate-producing microbe can provide a therapeutic effect for subjects having prediabetes or type 2 diabetes. Therapeutic effects can include a reduction in hemoglobin A1C levels, a reduction in glucose area under the curve after a meal tolerance test, or a reduction in the fasting glucose level.

US Patent:

20210205374, Jul 8, 2021

Filed:

Jan 15, 2021

Appl. No.:

17/150501

Inventors:

- San Francisco CA, US
Colleen CUTCLIFFE - Menlo Park CA, US
James H. BULLARD - San Francisco CA, US
Nicholas JUSTICE - San Francisco CA, US
Jessica GINES - San Francisco CA, US
Surabhi TYAGI - San Francisco CA, US
Marcus F. SCHICKLBERGER - Richmond CA, US
Andrew T. CHENG - San Mateo CA, US
Paul MCMURDIE - San Francisco CA, US
Christian SIEBER - San Francisco CA, US

International Classification:

A61K 35/74
A61P 37/06
A61K 38/28

Abstract:

The disclosure provides compositions and methods for therapeutic administration of the compositions to treat comorbidities associated with gut dysbiosis. The disclosure also provides compositions and methods for increasing engraftment of administered microbes. The disclosure also provides methods for stool sample collection.

US Patent:

20200121738, Apr 23, 2020

Filed:

Jun 4, 2019

Appl. No.:

16/431257

Inventors:

- San Francisco CA, US
John S. EID - San Francisco CA, US
James H. Bullard - San Francisco CA, US
Marcus F. SCHICKLBERGER - Richmond CA, US
Andrew T. CHENG - San Mateo CA, US
Orville G. KOLTERMAN - La Jolla CA, US
Tomer ALTMAN - San Francisco CA, US

International Classification:

A61K 35/741
C12N 1/20
A61K 9/00
A61K 9/19
A61K 31/733
A23L 33/135

Abstract:

The present disclosure provides a method for formulating a composition of isolated and purified microbes. The present disclosure provides methods for formulating a composition for administration to a subject in need thereof. The method can comprise obtaining a mixture that is substantially dry and comprises about 10% or less residual moisture. The mixture can comprise a population of isolated and purified microbes and a pharmaceutically acceptable carrier. The population can comprise one or more obligate anaerobes that are oxygen-stable. The methods can further comprise encapsulating said mixture in an enteric-coated capsule for delivery to said subject.

US Patent:

20180085387, Mar 29, 2018

Filed:

Sep 26, 2017

Appl. No.:

15/716249

Inventors:

- Foster City CA, US
Andrew Cheng - San Francisco CA, US
William A. Lee - Foster City CA, US
Diana Sperger - Belmont CA, US
Monica Tijerina - Foster City CA, US

International Classification:

A61K 31/7076
A61K 31/426
A61K 31/42
A61K 31/4995
A61K 31/4375
A61K 31/27
A61K 31/664
A61K 31/18

Abstract:

Pharmaceutical formulations suitable for treating viral infections such as HIV are provided, in particular solid oral dosage forms including the compounds of Formula I, Formula II, Formula III, Formula IV, or pharmaceutically acceptable salts or solvates thereof, and one or more excipients.

US Patent:

20160271189, Sep 22, 2016

Filed:

Mar 18, 2016

Appl. No.:

15/074923

Inventors:

- San Francisco CA, US
John S. Eid - San Francisco CA, US
James H. Bullard - San Francisco CA, US
Marcus F. SCHICKLBERGER - Richmond CA, US
Andrew T. CHENG - San Mateo CA, US

International Classification:

A61K 35/74
A61K 31/715
A61K 38/48
A61K 33/40
A61K 9/00
A61K 31/4172

Abstract:

The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The disclosure provides compositions and methods for the treatment of skin disorders using microbial compositions to a subject.