Andrew Z Fire

US Patent:

6506559, Jan 14, 2003

Filed:

Dec 18, 1998

Appl. No.:

09/215257

Inventors:

Andrew Fire - Baltimore MD
Stephen Kostas - Chicago IL
Mary Montgomery - St. Paul MN
Lisa Timmons - Lawrence KS
SiQun Xu - Ballwin MO
Hiroaki Tabara - Shizuoka, JP
Samuel E. Driver - Providence RI
Craig C. Mello - Shrewsbury MA

Assignee:

Carnegie Institute of Washington - Washington DC

International Classification:

C12Q 168

US Classification:

435 6, 435 911, 435325

Abstract:

A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

US Patent:

7282564, Oct 16, 2007

Filed:

Aug 20, 2003

Appl. No.:

10/645746

Inventors:

Craig C. Mello - Shrewsbury MA, US
Andrew Fire - Baltimore MD, US
Hiroaki Tabara - Worcester MA, US
Alla Grishok - Shrewsbury MA, US

Assignee:

University of Massachusetts - Boston MA
Carnegie Institute of Washington - Washington DC

International Classification:

C12P 21/06
C12N 15/00
C12N 1/20
C07K 1/00

US Classification:

530350, 435 691, 4352523, 4353201

Abstract:

Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.

US Patent:

7538095, May 26, 2009

Filed:

Oct 30, 2002

Appl. No.:

10/282996

Inventors:

Andrew Fire - Baltimore MD, US
Stephen Kostas - Chicago IL, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Shizuoka, JP
Samuel E. Driver - Providence RI, US
Craig C. Mello - Shrewsbury MA, US

Assignee:

The Carnegie Institution of Washington - Washington DC
The University of Massachusetts - Boston MA

International Classification:

A61K 31/70
C07H 21/04
C12N 5/00
C12N 15/00
C12Q 1/68
C12P 19/34

US Classification:

514 44, 536 245, 435 6, 435 913, 4353201, 435325

Abstract:

A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

US Patent:

7560438, Jul 14, 2009

Filed:

Oct 30, 2002

Appl. No.:

10/283190

Inventors:

Andrew Fire - Baltimore MD, US
Stephen Kostas - Chicago IL, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Shizuoka, JP
Samuel E. Driver - Providence RI, US
Craig C. Mello - Shrewsbury MA, US

Assignee:

The Carnegie Institution of Washington - Washington DC
The University of Massachusetts - Boston MA

International Classification:

A61K 31/70
C07H 21/04
C12N 5/00
C12N 15/00
C12Q 1/68
C12P 19/34

US Classification:

514 44, 536 235, 435 6, 435 913, 4353201, 435325

Abstract:

A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

US Patent:

7622633, Nov 24, 2009

Filed:

Oct 30, 2002

Appl. No.:

10/283267

Inventors:

Andrew Fire - Baltimore MD, US
Stephen Kostas - Chicago IL, US
Mary Montgomery - St. Paul MN, US
Lisa Timmons - Lawrence KS, US
SiQun Xu - Ballwin MO, US
Hiroaki Tabara - Shizuoka, JP
Samuel E. Driver - Providence RI, US
Craig C. Mello - Shrewsbury MA, US

Assignee:

Carnegie Institution of Washington - Washington DC

International Classification:

C12N 15/82
C12N 15/90
C12N 5/10

US Classification:

800285, 435468

Abstract:

A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with double-stranded structure. Inhibition is sequence-specific in that the nucleotide sequences of the duplex region of the RNA and of a portion of the target gene are identical. The present invention is distinguished from prior art interference in gene expression by antisense or triple-strand methods.

US Patent:

7759463, Jul 20, 2010

Filed:

Feb 22, 2007

Appl. No.:

11/710152

Inventors:

Craig C. Mello - Shrewsbury MA, US
Hiroaki Tabara - Worcester MA, US
Andrew Fire - Baltimore MD, US
Alla Grishok - Shrewsbury MA, US

Assignee:

University of Massachusetts - Boston MA

International Classification:

C07K 16/00
C12P 21/08

US Classification:

5303879, 5303881, 5303873, 5303891, 530350

Abstract:

Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.

US Patent:

20050100913, May 12, 2005

Filed:

Aug 20, 2003

Appl. No.:

10/645735

Inventors:

Craig Mello - Shrewsbury MA, US
Andrew Fire - Baltimore MD, US
Hiroaki Tabara - Worcester MA, US
Alla Grishok - Shrewsbury MA, US

Assignee:

UNIVERSITY OF MASSACHUSETTS MEDICAL - Boston MA

International Classification:

C12Q001/68
C07H021/02
C12N009/22

US Classification:

435006000, 435069100, 435199000, 435320100, 435325000, 536023100

Abstract:

Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.

US Patent:

20060024798, Feb 2, 2006

Filed:

Jun 3, 2005

Appl. No.:

11/144985

Inventors:

Craig Mello - Shrewsbury MA, US
Andrew Fire - Baltimore MD, US
Hiroaki Tabara - Worcester MA, US
Alla Grishok - Shrewsbury MA, US

Assignee:

UNIVERSITY OF MASSACHUSETTS - Boston MA

International Classification:

A61K 48/00
C12P 19/34
C12N 15/88

US Classification:

435091100, 435458000, 514044000

Abstract:

Genes involved in double-stranded RNA interference (RNAi pathway genes) are identified and used to investigate the RNAi pathway. The genes and their products are also useful for modulating RNAi pathway activity.

Address:

834 Allardice Way, Stanford, CA 94305

Phone:

(650)4808204

VIN:

JTDZN3EU3C3112476

Make:

TOYOTA

Model:

PRIUS V

Year:

2012