Andrew C Hatch

US Patent:

20120091059, Apr 19, 2012

Filed:

Nov 3, 2010

Appl. No.:

12/938715

Inventors:

Neil Reginald Beer - Pleasanton CA, US
Abraham P. Lee - Irvine CA, US
Andrew C. Hatch - Irvine CA, US
Jeffrey S. Fisher - Irvine CA, US

International Classification:

B81B 1/00
C12M 1/00
B01J 19/00
B01D 63/00

US Classification:

210634, 2103216, 4352831, 422129

Abstract:

An apparatus for passive sorting of microdroplets including a main flow channel, a flow stream of microdroplets in the main flow channel wherein the microdroplets have substantially the same diameter and wherein the flow stream of microdroplets includes first microdroplets having a first degree of stiffness and second microdroplets having a second degree of stiffness wherein the second degree of stiffness is different than the first degree of stiffness. A second flow channel is connected to the main flow channel for the second microdroplets having a second degree of stiffness. A separator separates the second microdroplets having a second degree of stiffness from the first microdroplets and directs the second microdroplets having a second degree of stiffness into the second flow channel.

US Patent:

20120184464, Jul 19, 2012

Filed:

Sep 29, 2011

Appl. No.:

13/249096

Inventors:

Abraham P. Lee - Irvine CA, US
Andrew C. Hatch - American Fork UT, US
Jeffrey S. Fisher - San Diego CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

C40B 40/08
C40B 50/18

US Classification:

506 17, 506 32

Abstract:

A method and device is disclosed for increasing droplet and micro-well reactor densities per unit area for microfluidic platforms. The device and method use controlled Height to Droplet Diameter Ratios (HDR) of the collection region which can produce different crystalline packing formations. HDR ratios above unity and less than about 2.65 are used to create a variety of three-dimensional packing schemes with increased density over conventional single layer hexagonal packing.

US Patent:

20130052649, Feb 28, 2013

Filed:

Aug 22, 2012

Appl. No.:

13/592071

Inventors:

Abraham P. Lee - Irvine CA, US
Andrew C. Hatch - Queen Creek AZ, US

International Classification:

B01L 3/00
C12M 1/34
B23P 17/04
G01N 21/78

US Classification:

435 612, 436 94, 4352872, 422552, 422 8205, 29428

Abstract:

A multilayer well device includes a first substrate comprising an array of wells having a first pattern disposed therein and a second substrate comprising an array of wells having a second pattern, complementary to the first pattern disposed therein, wherein the second substrate is secured adjacent to a face of the first substrate. A common channel is interposed between the array of wells of the respective first and second substrates and is coupled to an inlet and an outlet.

US Patent:

20220288591, Sep 15, 2022

Filed:

May 27, 2022

Appl. No.:

17/827614

Inventors:

- Scottsdale AZ, US
Andrew HATCH - Tempe AZ, US
Andrew LARSEN - Scottsdale AZ, US
Tathagata RAY - Tempe AZ, US
Matthew UNDERHILL - Gilbert AZ, US

International Classification:

B01L 3/00
B01L 7/00
C12Q 1/6848

Abstract:

Described herein are systems relating to a continuous-flow instrument that includes all necessary components for digital droplet quantification without the need to introduce key reagents or collect and transfer droplets between stages of instrument operation. Digital quantification can proceed without any additional fluid or consumable handling and without exposing fluids to risk of external contamination.

US Patent:

20220193681, Jun 23, 2022

Filed:

Jul 29, 2021

Appl. No.:

17/389253

Inventors:

- Scottsdale AZ, US
Andrew HATCH - Tempe AZ, US
Tathagata RAY - Tempe WA, US
Andrew LARSEN - Scottsdale AZ, US
Matthew UNDERHILL - Gilbert AZ, US

International Classification:

B01L 7/00
G01N 35/10
B01L 3/00
C12Q 1/686
G01N 1/10

Abstract:

Systems and methods for continuous flow polymerase chain reaction (PCR) are provided. The system comprises an injector, a mixer, a coalescer, a droplet generator, a detector, a digital PCR system, and a controller. The injector takes in a sample, partitions the sample into sample aliquots with the help of an immiscible oil phase, dispenses waste, and sends the sample aliquot to the mixer. The mixer mixes the sample aliquot with a PCR master mix and diluting water, dispenses waste, and sends the sample mixture (separated by an immiscible oil) to the coalescer. The coalescer coalesces the sample mixture with primers dispensed from a cassette, dispenses waste, and sends the reaction mixture (separated by an immiscible oil) to the droplet generator. The droplet generator converts the sample mixture into an emulsion where aqueous droplets of the reaction mixture are maintained inside of an immiscible oil phase and dispenses droplets to the digital PCR system. The digital PCR system amplifies target DNAs in the droplets. The detector detects target DNAs in the droplets. The controller controls the system to run automatically and continuously.

US Patent:

20210123089, Apr 29, 2021

Filed:

Jun 7, 2019

Appl. No.:

16/631395

Inventors:

- Salt Lake City UT, US
Andrew Hemmert - Murray UT, US
Robert Crisp - Cottonwood Heights UT, US
Elizabeth Diana Campbell - West Valley City UT, US
Karina S. Kirk - Salt Lake City UT, US
Andrew Carter Hatch - West Jordan UT, US

International Classification:

C12Q 1/686

Abstract:

Instruments, methods, and kits are disclosed for performing fast thermocycling.

US Patent:

20200261914, Aug 20, 2020

Filed:

May 23, 2018

Appl. No.:

16/642797

Inventors:

- Salt Lake City UT, US
- Marcy, FR
Ali Laayoun - La Frette, FR
Carole Vachon - Saint Etienne de Crossey, FR
Agnes Dupont-Fillard - Les Adrets, FR
Laurent Mesta - Genas, FR
Andrew C. Hatch - West Jordan UT, US
Erik W. Huynh - West Jordan UT, US
David E. Jones - Layton UT, US

International Classification:

B01L 7/00
B01L 3/00

Abstract:

Systems, methods, and apparatuses are provided for self-contained nucleic acid preparation, amplification, and analysis.

US Patent:

20190291114, Sep 26, 2019

Filed:

May 15, 2019

Appl. No.:

16/413416

Inventors:

- Scottsdale AZ, US
Andrew HATCH - Tempe AZ, US
Andrew LARSEN - Scottsdale AZ, US

International Classification:

B01L 3/00
C12Q 1/6848
B01L 7/00

Abstract:

Described herein are systems relating to a continuous-flow instrument that includes all necessary components for digital droplet quantification without the need to introduce key reagents or collect and transfer droplets between stages of instrument operation. Digital quantification can proceed without any additional fluid or consumable handling and without exposing fluids to risk of external contamination.