Arun K. Ghosh - West Lafayette IN, US Jun Takayama - West Lafayette IN, US Andrew David Mesecar - Chicago IL, US Michael E. Johnson - Chicago IL, US Kiira M. Ratia - Chicago IL, US Rima Chaudhuri - Chicago IL, US Debbie C. Mulhearn - Chicago IL, US
Assignee:
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS - Urbana IL PURDUE RESEARCH FOUNDATION - West Lafayette IN
Described herein are compounds and compositions, and methods for using the compounds and compositions, for treating respiratory diseases and illness, such as severe acute respiratory syndrome (SARS).
- West Lafayette IN, US Andrew Mesecar - West Lafayette IN, US Margherita Brindisi - Corleto Perticara, IT Emilio Leal Cardenas - West Lafayette IN, US
Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.
Bace1 Inhibitors For The Treatment Of Alzheimer's Disease
- West Lafayette IN, US Andrew Mesecar - West Lafayette IN, US Margherita Brindisi - Corleto Perticara, IT Emilio Leal Cardenas - West Lafayette IN, US
Described herein are compounds of the formulae (I)-(III) as well as pharmaceutical compositions comprising such compounds and methods for using such compounds/pharmaceutical compositions for treating Alzheimer's disease.
6-Amino-2,4-Dihydropyrano [2,3-C] Pyrazoles And Methods Of Use
- West Lafayette IN, US Andrew Mesecar - West Lafayette IN, US
Assignee:
Purdue Research Foundation - West Lafayette IN
International Classification:
A61K 31/4162 C07D 491/052 A61K 45/06
Abstract:
The present invention generally relates to 6-amino-2,4-dihydropyrano [2,3-c] pyrazoles as a ubiquitin specific protease 7 (USP7) inhibitor useful for the treatment of diseases mediated by malfunction of USP7, such as inflammation, cancer, and immunological disorders. The invention described herein also pertains to pharmaceutical compositions and methods for treating diseases mediated by malfunction of USP7, in mammals using compounds disclosed herein.
This invention pertains to materials and methods for the treatment of patients with coronavirus infection and the control of zoonotic disease outbreaks using broad-spectrum non-covalent coronavirus protease inhibitors.
Name / Title
Company / Classification
Phones & Addresses
Andrew Mesecar Director
Advanced Life Sciences Holdings, Inc A Development Stage Company Engaged In Biopharmaceutical Research & Development · Commercial Physical Research Mfg Biological Products
1440 Davey Rd, Downers Grove, IL 60517 (630)7396744
Purdue University
Professor and Head, Department of Biochemistry
Purdue University
Deputy Director, Center For Cancer Research
Education:
University of California, Berkeley 1994 - 1998
Doctorates, Biology
University of Notre Dame 1988 - 1994
Doctorates, Doctor of Philosophy, Biochemistry, Philosophy
Purdue University 1984 - 1988
Bachelors, Bachelor of Science, Chemistry
James Whitcomb Riley High School
Skills:
Biochemistry Science Molecular Biology Protein Chemistry Cell Culture Protein Expression Life Sciences Protein Purification Chemistry Pcr Research Biotechnology Western Blotting Spectroscopy Higher Education Microbiology Structural Biology Lifesciences Mentoring X Ray Crystallography Grant Writing Assay Development Enzyme Kinetics Isothermal Titration Calorimetry Drug Discovery Molecular Cloning Data Analysis Teaching Cancer Research
News
Viral Outbreaks Are Here to Stay. This is How Humans Will Fight Back
Scientists shouldnt be relying on private companies in this way, says Andrew Mesecar, a coronavirus researcher and head of biochemistry at Purdue University, who researches coronaviruses. He is currently working on a solution: he and his team have studied the proteins, or enzymes, that different st
Date: Jan 30, 2020
Category: Health
Source: Google
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