Andrew G Meyer

US Patent:

7456315, Nov 25, 2008

Filed:

Feb 26, 2004

Appl. No.:

10/787906

Inventors:

Robert Eugene Hormann - Melrose Park PA, US
David W. Potter - North Wales PA, US
Orestes Chortyk - Thompson Station TN, US
Colin M. Tice - Elkins Park PA, US
Glenn Richard Carlson - North Wales PA, US
Andrew Meyer - Maple Glen PA, US
Thomas R. Opie - North Wales PA, US

Assignee:

Intrexon Corporation - Blacksburg VA

International Classification:

C07C 243/38
C07D 213/63

US Classification:

564148, 564 36, 564149, 5483044, 5483335, 5483611, 5483711, 548469, 544224, 544242, 544336, 546291, 546292

Abstract:

The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

US Patent:

7563928, Jul 21, 2009

Filed:

Aug 20, 2007

Appl. No.:

11/841568

Inventors:

Robert Eugene Hormann - Melrose Park PA, US
David W. Potter - North Wales PA, US
Orestes Chortyk - Thompson Station TN, US
Colin M. Tice - Elkins Park PA, US
Glenn Richard Carlson - North Wales PA, US
Andrew Meyer - Maple Glen PA, US
Thomas R. Opie - North Wales PA, US

Assignee:

Intrexon Corporation - Blacksburg VA

International Classification:

C01C 243/32
A61K 31/16

US Classification:

564149, 564148, 514614, 514615

Abstract:

The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

US Patent:

8524948, Sep 3, 2013

Filed:

Sep 23, 2011

Appl. No.:

13/243210

Inventors:

Robert Eugene Hormann - Melrose Park PA, US
David W. Potter - North Wales PA, US
Orestes Chortyk - Thompson Station TN, US
Colin M. Tice - Elkins Park PA, US
Glenn Richard Carlson - North Wales PA, US
Andrew Meyer - Maple Glen PA, US
Thomas R. Opie - North Wales PA, US

Assignee:

Intrexon Corporation - Blacksburg VA

International Classification:

C07C 243/18
A61K 31/16

US Classification:

564148, 514615

Abstract:

The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

US Patent:

20080077602, Mar 27, 2008

Filed:

Dec 16, 2005

Appl. No.:

11/303656

Inventors:

Rand Warsaw - Monroeville PA, US
Andrew J. Meyer - Pittsburgh PA, US
Vijay Parmar - Pittsburgh PA, US

Assignee:

WEATHERWISE USA, INC. - PITTSBURGH PA

International Classification:

G06F 17/30

US Classification:

707101, 707E17001

Abstract:

An operating system independent computer language to enable non-technical users to manipulate data from within large pre-existing files or databases with limited involvement of programmers. This language can also be used to distribute the processing for such file manipulations across any group of networked computers.

US Patent:

20130035487, Feb 7, 2013

Filed:

Sep 5, 2012

Appl. No.:

13/603965

Inventors:

Robert Eugene HORMANN - Elkins Park PA, US
David W. Potter - North Wales PA, US
Orestes Chortyk - Thompson Station TN, US
Colin M. Tice - Elkins Park PA, US
Glenn Richard Carlson - North Wales PA, US
Andrew Meyer - Maple Glen PA, US
Thomas R. Opie - North Wales PA, US

Assignee:

Intrexon Corporation - Blacksburg VA

International Classification:

C07D 241/24
C07C 243/18
C07F 7/10
C07C 229/34
C07D 235/06
C07D 319/08

US Classification:

544406, 5483044, 5483094, 549365, 556419, 560 38, 562443, 564149

Abstract:

The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

US Patent:

20130040389, Feb 14, 2013

Filed:

Sep 5, 2012

Appl. No.:

13/604001

Inventors:

Robert Eugene HORMANN - Elkins Park PA, US
David W. Potter - North Wales PA, US
Orestes Chortyk - Thompson Station TN, US
Colin M. Tice - Elkins Park PA, US
Glenn Richard Carlson - North Wales PA, US
Andrew Meyer - Maple Glen PA, US
Thomas R. Opie - North Wales PA, US

Assignee:

Intrexon Coporation - Blacksburg VA

International Classification:

C07C 243/38
C07D 407/12
C07C 317/28
C07D 241/24
C07D 319/14
C07D 235/08
C07D 209/42
C07D 233/90
C07D 231/56
C07D 405/12
C12N 5/00
C07D 213/81

US Classification:

435375, 564149, 549365, 564150, 560251, 544406, 546322, 5483044, 548492, 5483335, 5483625, 5462824, 549362

Abstract:

The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

US Patent:

20140045903, Feb 13, 2014

Filed:

Jul 30, 2013

Appl. No.:

13/954376

Inventors:

David W. Potter - North Wales PA, US
Orestes Chortyk - Thompson TN, US
Colin M. Tice - Elkins Park PA, US
Glenn Richard Carlson - North Wales PA, US
Andrew Meyer - Maple Glen PA, US
Thomas R. Opie - North Wales PA, US

Assignee:

Intrexon Corporation - Blacksburg VA

International Classification:

C07D 319/18
C07D 213/87
C07C 243/18

US Classification:

514346, 549362, 564150, 546291, 514452, 514615

Abstract:

The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

US Patent:

20160039750, Feb 11, 2016

Filed:

Aug 4, 2015

Appl. No.:

14/817901

Inventors:

- Blacksburg VA, US
David W. Potter - North Wales PA, US
Orestes Chortyk - Thompson Station TN, US
Colin M. Tice - Elkins Park PA, US
Glenn Richard Carlson - North Wales PA, US
Andrew Meyer - Maple Glen PA, US
Thomas R. Opie - North Wales PA, US

Assignee:

Intrexon Corporation - Blacksburg VA

International Classification:

C07C 241/04
A61K 31/357
C07D 319/08
A61K 31/222
C07C 315/02
A61K 31/4965
C07D 241/24
A61K 31/455
C07D 213/86
A61K 31/4184
C07D 235/24
A61K 31/404
C07D 209/42
A61K 31/415
C07D 231/14
A61K 31/166

Abstract:

The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.