Andrew G Myers

US Patent:

6809099, Oct 26, 2004

Filed:

Nov 5, 2001

Appl. No.:

10/011466

Inventors:

Andrew G. Myers - Boston MA
Alleyn T. Plowright - Didsbury, GB
Daniel W. Kung - Salem CT
Brian Lanman - Cambridge MA

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 314985

US Classification:

514250, 544342

Abstract:

In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof. In another aspect, the present invention provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. In yet another aspect, the present invention provides methods for treating cancer comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof.

US Patent:

7065187, Jun 20, 2006

Filed:

Jan 10, 2002

Appl. No.:

10/041571

Inventors:

Andrew Myers - Wayland MA, US
Srinivasa Rao Kolaparthi - North Chelmsford MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

H04M 1/64

US Classification:

379 8822, 379 8811

Abstract:

A system and method for enabling annotation of audible voice messages in a unified communication services (UCS) system. In some embodiments, subscribers access a message presentation form that enables simultaneous playback and annotation of audible voice messages.

US Patent:

7122549, Oct 17, 2006

Filed:

Apr 16, 2004

Appl. No.:

10/826859

Inventors:

Andrew G. Myers - Boston MA, US
Alleyn T. Plowright - Manchester, GB

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 31/4985
C07O 471/18

US Classification:

514250, 544342

Abstract:

In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof. In another aspect, the present invention provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. In yet another aspect, the present invention provides methods for treating cancer comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof.

US Patent:

7143417, Nov 28, 2006

Filed:

Jan 10, 2002

Appl. No.:

10/041570

Inventors:

Andrew Myers - Wayland MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 9/44

US Classification:

719318, 719312, 709213

Abstract:

A system and method for providing notification of significant events such as received or disposed of messages in a unified communication services network. Notifications are event based and may be filtered according to predetermined criteria. One or more event managers may, among other things, manage the receipt and dispersal of event notifications and pass the notifications to one or more notification handlers for dispersal of the notifications to subscribers.

US Patent:

7183054, Feb 27, 2007

Filed:

Jun 3, 2003

Appl. No.:

10/453243

Inventors:

Andrew G. Myers - Boston MA, US
Jacob R. LaPorte - Cambridge MA, US
Chengguo Xing - Minneapolis MN, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C12Q 1/68
C12Q 1/70
G01N 33/53
C07H 21/00
A61K 31/70
A61K 38/00
A01N 61/00

US Classification:

435 6, 536 231, 536 243, 530300, 514 1, 514 44, 435 5, 435 71, 435 72

Abstract:

The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also provides methods of screening chemical compounds for those which act in a similar method and may be more potent than known compounds. The inventive methods are particularly useful in the high-throughput screening of chemical compounds that target GAPDH. The invention also provides kits useful in the practice of the inventive method. Compounds identified by inventive methods are also included in the invention.

US Patent:

7502924, Mar 10, 2009

Filed:

Jan 25, 2005

Appl. No.:

11/042559

Inventors:

David J. Miller - Burlington MA, US
Andrew S. Myers - Wayland MA, US
John C. Wray - Chelmsford MA, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

H04L 9/00

US Classification:

713156, 713155, 713150

Abstract:

The present invention provides a method, system, and computer program product for transparent on-demand certificate provisioning for secure email. The method comprises: generating a keypair and a self-signed certificate; requesting a certificate from a certification authority; temporarily securing email using the self-signed certificate; and securing email using the requested certificate, after receipt of the requested certificate from the certification authority. The present inventions uses self-signed certificates as an initial, interim security mechanism, provides automatic submission of certificate requests and renewal requests, provides an administrative policy to specify when keypairs and self-signed certificates are generated by a user's client system, and when certificate requests are submitted, and provides automatic transition from end-user defined trust to delegated trust based upon CA-issued certificates.

US Patent:

7691896, Apr 6, 2010

Filed:

Feb 8, 2008

Appl. No.:

12/028024

Inventors:

Andrew G. Myers - Boston MA, US
Binyuan Sun - Boston MA, US
Stona R Jackson - Seattle WA, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

A61K 31/407
C07D 491/044

US Classification:

514421, 548453

Abstract:

Disclosed herein are analogs of Salinosporamide A, having the Formula I as follows:.

US Patent:

7763735, Jul 27, 2010

Filed:

Oct 11, 2007

Appl. No.:

11/870772

Inventors:

Andrew G. Myers - Boston MA, US
Jason D. Brubaker - Cheshire CT, US

Assignee:

President and Fellows of Harvard College - Cambridge MA

International Classification:

C07D 261/20
C07D 261/12

US Classification:

548242, 548243

Abstract:

The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides a more efficient route for preparing the enone intermediate.