Andrew D Myers

US Patent:

57634513, Jun 9, 1998

Filed:

Feb 8, 1996

Appl. No.:

8/598316

Inventors:

Andrew Gordon Myers - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

A61K 3144
C07D22118
C07D49100
C07D51300

US Classification:

514279

Abstract:

Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.

US Patent:

54881315, Jan 30, 1996

Filed:

Mar 23, 1994

Appl. No.:

8/216926

Inventors:

Andrew G. Myers - Pasadena CA

Assignee:

California Institute of Technology

International Classification:

C07C27100
C07C23304

US Classification:

560 3

Abstract:

A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxiliary can then be cleaved off, affording chiral end products useful for further transformations. The enantiomeric enrichment of the chiral end products may exceed 98%, and the chiral auxiliary can be recovered. Novel amides of pseudoephedrine used in this method are also disclosed.

US Patent:

58497501, Dec 15, 1998

Filed:

Mar 5, 1997

Appl. No.:

8/811826

Inventors:

Andrew Gordon Myers - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

A16K 3147

US Classification:

514279

Abstract:

Non-naturally occuring dynemicin analogs are provided, which are useful as DNA cleaving agents, cytotoxic agents, and/or anti-tumor compounds. Methods of making dynemicin analogs are also provided.

US Patent:

57602379, Jun 2, 1998

Filed:

Aug 25, 1995

Appl. No.:

8/519650

Inventors:

Andrew G. Myers - Pasadena CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C07D21316
A61K 3144

US Classification:

546300

Abstract:

A practical synthesis of the potential chemotherapeutic agent L-azatyrosine is described. The key step involved the alkylation of (R,R)-(-)-pseudoephedrine glycinamide with 5-benzenesulfonyloxy-2-iodomethylpyridine and proceeded in 70-95% yield and 89-95% de. Simultaneous hydrolysis of the auxiliary and the benzenesulfonate protecting group afforded L-azatyrosine of. gtoreq. 99% ee in 73% yield on multigram scale (recovery yield of (R,R)-(-)-pseudoephedrine: 90%).