Andrew J Price

US Patent:

20220314187, Oct 6, 2022

Filed:

Dec 29, 2021

Appl. No.:

17/565038

Inventors:

- Pleasanton CA, US
Andrew D. PRICE - San Diego CA, US

International Classification:

B01J 19/00
C12Q 1/6834

Abstract:

Provided in some aspects are methods for light-controlled in situ surface patterning of an array. Compositions such as nucleic acid arrays produced by the methods are also disclosed.

US Patent:

20220228201, Jul 21, 2022

Filed:

Dec 29, 2021

Appl. No.:

17/565028

Inventors:

- Pleasanton CA, US
David Michael PATTERSON - Oakland CA, US
Andrew D. PRICE - San Diego CA, US
Eswar Prasad RAMACHANDRAN IYER - Sunnyvale CA, US

International Classification:

C12Q 1/6837
C12Q 1/6869

Abstract:

Provided in some aspects are methods for light-controlled in situ surface patterning of a substrate. Compositions such as nucleic acid arrays produced by the methods are also disclosed. In some embodiments, provided herein is photocontrollable hybridization, where oligonucleotides with photo-caged bases prevent hybridization of complementary nucleic acid strands. Uncaging of the oligonucleotides allows hybridization and/or ligation of nucleic acid molecules at the exposed area. A large diversity of barcodes can be created in molecules on the substrate via sequential rounds of light exposure, hybridization, and ligation.

US Patent:

20200239954, Jul 30, 2020

Filed:

Jan 23, 2020

Appl. No.:

16/750897

Inventors:

- San Diego CA, US
Tarun Kumar Khurana - Freemont CA, US
Liangliang Qiang - San Diego CA, US
Andrew J. Price - San Mateo CA, US
Elisabet Rosas - El Cerrito CA, US

International Classification:

C12Q 1/6874
C12N 15/10

Abstract:

An example of a sequencing kit includes a flow cell, an encapsulation matrix precursor composition, and a radical initiator. The flow cell includes a plurality of chambers and primers attached within each of the plurality of chambers. The encapsulation matrix precursor composition consists of a fluid, a monomer or polymer including a radical generating and chain elongating functional group, a radical source, and a crosslinker. The radical initiator is part of the encapsulation matrix precursor composition or is a separate component.