Andrew J Schaeffer

US Patent:

20030119070, Jun 26, 2003

Filed:

Jul 29, 2002

Appl. No.:

10/209323

Inventors:

Andrew Schaeffer - La Mirada CA, US
Janet Tseng-Law - Aliso Viejo CA, US
Jeffrey Thornton - Rancho Santa Margarita CA, US
Dennis Van Epps - Coto de Caza CA, US

Assignee:

Nexell Therapeutics, Inc.

International Classification:

G01N033/53
G01N033/567
G01N033/574
C12N005/08
C07K016/30

US Classification:

435/007200, 530/388220, 530/391100, 435/372000, 435/007230

Abstract:

The present invention provides peptide-ligand conjugates containing a peptide, where a free form of the peptide is capable of displacing a second ligand specific for the peptide. The invention also provides a method of selecting a cell. The method includes the steps of contacting a cell population with a peptide-ligand conjugate, wherein the conjugate comprises a first ligand specific for a cell in the population conjugated to a peptide capable of displacing a second ligand specific for the peptide, thereby forming a cell-conjugate complex; contacting the peptide-ligand conjugate with the second ligand; and isolating the cell-conjugate complex. The method can further include the step of adding a free form of the peptide to release the cell from the complex. The invention also provides a subpopulation of cells containing two or more specifically isolated cells and methods of isolating cell subpopulations. The invention additionally provides a method of diagnosing a condition using peptide-ligand conjugates. The invention further provides a kit for isolating a cell containing a peptide capable of displacing an antibody specific for the peptide and the antibody.

US Patent:

20030219445, Nov 27, 2003

Filed:

Sep 25, 2002

Appl. No.:

10/256277

Inventors:

Andrew Schaeffer - La Mirada CA, US
Janet Tseng-Law - Aliso Viejo CA, US
Jeffrey Thornton - Rancho Santa Margarita CA, US

Assignee:

Nexell Therapeutics, Inc.

International Classification:

A61K039/395
C07K016/46

US Classification:

424/178100, 530/391100

Abstract:

The present invention provides peptide-ligand conjugates containing a peptide, where a free form of the peptide is capable of displacing a second ligand specific for the peptide. The invention also provides a method of selecting a cell. The method includes the steps of contacting a cell population with a peptide-ligand conjugate, wherein the conjugate comprises a first ligand specific for a cell in the population conjugated to a peptide capable of displacing a second ligand specific for the peptide, thereby forming a cell-conjugate complex; contacting the peptide-ligand conjugate with the second ligand; and isolating the cell-conjugate complex. The method can further include the step of adding a free form of the peptide to release the cell from the complex. The invention additionally provides a method of diagnosing a condition using peptide-ligand conjugates. The invention further provides a kit for isolating a cell containing a peptide capable of displacing an antibody specific for the peptide and the antibody.

US Patent:

20180052112, Feb 22, 2018

Filed:

Oct 27, 2017

Appl. No.:

15/796220

Inventors:

- Redondo Beach CA, US
Brian R. Fernandez - Los Angeles CA, US
Andrew T. Schaeffer - Redondo Beach CA, US
Mina Ghadessi - Irvine CA, US

International Classification:

G01N 21/78
B32B 37/14
B01L 3/00
B32B 38/00
A61B 10/00

Abstract:

A liquid holding liquid holding apparatus for insertion of a test device into a test liquid, the liquid holding apparatus having a) a liquid holding device for holding test liquid; and b) test liquid in the liquid holding device. The liquid holding device has a front wall and a rear wall. The upper section of the liquid holding device has an access section where the front wall can be detached from the rear wall to allow access for a test strip test device. At least a portion of the front wall is substantially transparent or translucent. The front wall is attached to the rear wall at the access section by a first lamination and the front wall is attached to the rear wall below the access section by a second lamination. The peel strength of the second lamination is greater than the peel strength of the first lamination.

US Patent:

20150314286, Nov 5, 2015

Filed:

May 5, 2014

Appl. No.:

14/269568

Inventors:

- Redondo Beach CA, US
Brian Robert Fernandez - Los Angeles CA, US
Andrew Todd Schaeffer - Redondo Beach CA, US
Mina Ghadessi - Irvine CA, US

International Classification:

B01L 3/00
B32B 38/00
B32B 37/14

Abstract:

A liquid holding apparatus has a liquid holding device and a backing attached to the liquid holding device. The liquid holding device has a front wall and a rear wall and includes a periphery wherein the front wall and the rear wall are sealed together. The upper section of the liquid holding device has an access section where the front wall can be detached from the rear wall to allow access for a test device. At least a portion of the front wall is substantially transparent. The backing is stiffer than both the front wall and the rear wall.

US Patent:

20150316484, Nov 5, 2015

Filed:

Jun 22, 2015

Appl. No.:

14/745657

Inventors:

- Redondo Beach CA, US
Brian Robert Fernandez - Los Angeles CA, US
Andrew Todd Schaeffer - Redondo Beach CA, US
Mina Ghadessi - Irvine CA, US

International Classification:

G01N 21/78
B32B 37/14

Abstract:

A liquid holding liquid holding apparatus for insertion of a test device into a test liquid, the liquid holding apparatus having a) a liquid holding device for holding test liquid; and b) test liquid in the liquid holding device. The liquid holding device has a front wall and a rear wall. The upper section of the liquid holding device has an access section where the front wall can be detached from the rear wall to allow access for a test strip test device. At least a portion of the front wall is substantially transparent or translucent. The front wall is attached to the rear wall at the access section by a first lamination and the front wall is attached to the rear wail below the access section by a second lamination. The peel strength of the second lamination is greater than the peel strength of the first lamination.