Andrew E Thompson

US Patent:

20130190500, Jul 25, 2013

Filed:

Dec 10, 2012

Appl. No.:

13/709802

Inventors:

Neuron Systems, Inc. - Burlington MA, US
Thomas Elliott Jacks - South Plainfield NJ, US
Andrew Steven Thompson - South Plainfield NJ, US

Assignee:

NEURON SYSTEMS, INC. - Burlington MA

International Classification:

C07D 215/38
C07C 221/00
C07D 215/48

US Classification:

546159, 564417

Abstract:

This invention relates to a process for the preparation of 6-chloro-3-amino-2-(2-hydroxypropyl)-1-azanapthalene. It comprises treating 6-chloro-3-pyridylium-2-ethoxycarbonyl-1-azanaphthanlene bromide with morpholine at about 80 C., followed by treating the product thereof with methylmagnesium chloride.

US Patent:

20210017155, Jan 21, 2021

Filed:

Feb 27, 2020

Appl. No.:

16/802959

Inventors:

- South San Francisco CA, US
- Cambridge MA, US
Tracy J. JENKINS - Watertown MA, US
Patrick CONLON - Wakefield MA, US
Xiongwei CAI - Arlington MA, US
Michael HUMORA - Cranbury NJ, US
Xianglin SHI - Cambridge MA, US
Ross A. MILLER - South Plainfield NJ, US
Andrew THOMPSON - Portola Valley CA, US

International Classification:

C07D 401/14

Abstract:

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

US Patent:

20190047986, Feb 14, 2019

Filed:

Mar 5, 2018

Appl. No.:

15/911546

Inventors:

- South San Francisco CA, US
- Cambridge MA, US
Tracy J. JENKINS - Watertown MA, US
Patrick CONLON - Wakefield MA, US
Xiongwei CAI - Arlington MA, US
Michael HUMORA - Cranbury NJ, US
Xianglin SHI - Cambridge MA, US
Ross A. MILLER - South Plainfield NJ, US
Andrew THOMPSON - Portola Valley CA, US

International Classification:

C07D 401/14

Abstract:

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

US Patent:

20180326130, Nov 15, 2018

Filed:

May 23, 2018

Appl. No.:

15/987310

Inventors:

- Canton MA, US
Andrew Thompson - Canton MA, US
Chinawut P. Paesang - Cumberland RI, US
Casper Crouse - Taunton MA, US
Elizabeth Nelson - Wellesley MA, US

International Classification:

A61M 1/06

Abstract:

Systems for expressing milk from a human breast are provided herein. Such systems can include a compression device having multiple fingers configured to at least partially surround a breast and apply pressure to a major portion of a breast without applying pressure to a remainder portion, thereby activating milk ducts within the breast. The fingers can be configured to apply pressure to an inferior portion and one or more lateral portions of the breast, without applying direct pressure to a superior portion. The fingers can be configured to apply pressure to a superior portion and one or more lateral portions of the breast, without applying direct pressure to an inferior portion. The fingers of the compression device can be configured to apply pressure to a superior portion, an inferior portion, and a first lateral portion of the breast, without applying direct pressure to a second lateral portion of the breast.

US Patent:

20180291001, Oct 11, 2018

Filed:

Jan 19, 2018

Appl. No.:

15/875629

Inventors:

- Cambridge MA, US
- South San Francisco CA, US
Timothy R. Chan - Newton MA, US
Patrick Conlon - Wakefield MA, US
Michael Humora - Weston MA, US
Tracy J. Jenkins - Watertown MA, US
J. Michael Macphee - Weston MA, US
Xianglin Shi - Weston MA, US
Ross A. Miller - South Plainfield NJ, US
Andrew Thompson - South Plainfield NJ, US

International Classification:

C07D 401/14
C07D 207/16
C07D 211/56
C07D 207/28
C07D 401/04

Abstract:

The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

US Patent:

20170114039, Apr 27, 2017

Filed:

May 27, 2016

Appl. No.:

15/167508

Inventors:

- Cambridge MA, US
- South San Francisco CA, US
Timothy R. Chan - Newton MA, US
Patrick Conlon - Wakefield MA, US
Michael Humora - Weston MA, US
Tracy J. Jenkins - Watertown MA, US
J. Michael Macphee - Weston MA, US
Xianglin Shi - Weston MA, US
Ross A. Miller - South Plainfield NJ, US
Andrew Thompson - South Plainfield NJ, US

International Classification:

C07D 401/14
C07D 401/04
C07D 207/16
C07D 211/56
C07D 207/28

Abstract:

The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

US Patent:

20160304494, Oct 20, 2016

Filed:

Jun 29, 2016

Appl. No.:

15/196389

Inventors:

- Cambridge MA, US
- South San Francisco CA, US
Tracy J. Jenkins - Watertown MA, US
Patrick Conlon - Wakefield MA, US
Xiongwei Cai - Weston MA, US
Michael Humora - Cranbury NJ, US
Xianglin Shi - Cambridge MA, US
Ross A. Miller - South Plainfield NJ, US
Andrew Thompson - South Plainfield NJ, US

International Classification:

C07D 401/14

Abstract:

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

US Patent:

20150158843, Jun 11, 2015

Filed:

Jun 7, 2013

Appl. No.:

14/406315

Inventors:

- Cambridge MA, US
- South San Francisco CA, US
Timothy R. Chan - Newton MA, US
Tracy J. Jenkins - Watertown MA, US
Xiongwei Cai - Arlington MA, US
Michael Humora - Weston MA, US
Xianglin Shi - Newton MA, US
Ross A. Miller - Fanwood NJ, US
Andrew Thompson - Mountainside NJ, US

International Classification:

C07D 401/14

Abstract:

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.