Angela Rios Wilkins

US Patent:

20140066382, Mar 6, 2014

Filed:

Nov 8, 2013

Appl. No.:

14/076150

Inventors:

Olivier Lichtarge - Dallas TX, US
Angela D. Wilkins - Houston TX, US

Assignee:

Baylor College of Medicine - Houston TX
Board of Regents, The University of Texas System - Dallas TX

International Classification:

C07K 14/47
C07K 14/005

US Classification:

514 189, 530324, 530317, 436501

Abstract:

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising beclin-1 residues 269-283 and a heterologous moiety that promotes therapeutic stability or delivery of the compound. The compound may be used to induce autophagy and in assays with beclin-1 binding partners.

US Patent:

20150359840, Dec 17, 2015

Filed:

Sep 3, 2015

Appl. No.:

14/844007

Inventors:

- Austin TX, US
- Houston TX, US
Nick V. Grishin - Dallas TX, US
Lisa N. Kinch - Dallas TX, US
Olivier Lichtarge - Houston TX, US
Angela D. Wilkins - Houston TX, US

Assignee:

BAYLOR COLLEGE OF MEDICINE - Houston TX
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

A61K 38/08
C07K 7/06

Abstract:

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 peptides immediately N- and C-terminally flanked by moieties Rand R, respectively, wherein up to six of said peptide residues may be substituted, Rand Rdo not naturally flank the Belclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.