Angela A Wilkins

US Patent:

20140066382, Mar 6, 2014

Filed:

Nov 8, 2013

Appl. No.:

14/076150

Inventors:

Olivier Lichtarge - Dallas TX, US
Angela D. Wilkins - Houston TX, US

Assignee:

Baylor College of Medicine - Houston TX
Board of Regents, The University of Texas System - Dallas TX

International Classification:

C07K 14/47
C07K 14/005

US Classification:

514 189, 530324, 530317, 436501

Abstract:

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising beclin-1 residues 269-283 and a heterologous moiety that promotes therapeutic stability or delivery of the compound. The compound may be used to induce autophagy and in assays with beclin-1 binding partners.

US Patent:

20160203118, Jul 14, 2016

Filed:

Mar 16, 2016

Appl. No.:

15/071743

Inventors:

- Armonk NY, US
- Houston TX, US
- Austin TX, US
Lawrence A. Donehower - Houston TX, US
Olivier Lichtarge - Houston TX, US
Sam J. Regenbogen - Houston TX, US
Angela D. Wilkins - Houston TX, US
Curtis R. Pickering - Houston TX, US

Assignee:

International Business Machines Corporation - Armonk NY
Baylor College of Medicine - Houston TX
The Board of Regents, The University of Texas System - Austin TX

International Classification:

G06F 17/27
G06F 17/30

Abstract:

A new information in a language and relating to a subject matter domain is parsed into a constituent set of complete grammatical constructs. In a subset of the complete grammatical constructs, a set of linguistic styles of the language is identified according to a subset of a set of word-style associations related to the language and independent of the subject matter domain. A first weight is assigned to a first linguistic style and a second weight to a second linguistic style from the set of linguistic styles. A first intention information is mapped to the first style using a first style-intention rule, and a second intention information to the second style using a second style-intention rule. A complete grammatical construct in the subset is tagged with the first intention information responsive to a weight associated with the first intention information exceeding an intention selection threshold.

US Patent:

20160162465, Jun 9, 2016

Filed:

Dec 8, 2014

Appl. No.:

14/564068

Inventors:

- Armonk NY, US
- Houston TX, US
- Austin TX, US
Lawrence A. Donehower - Houston TX, US
Olivier Lichtarge - Houston TX, US
Sam J. Regenbogen - Houston TX, US
Angela D. Wilkins - Houston TX, US
Curtis R. Pickering - Houston TX, US

Assignee:

International Business Machines Corporation - Armonk NY
Baylor College of Medicine - Houston TX
The Board of Regents, The University of Texas System - Austin TX

International Classification:

G06F 17/27
G06F 17/28

Abstract:

A new information in a language and relating to a subject matter domain is parsed into a constituent set of complete grammatical constructs. In a subset of the complete grammatical constructs, a set of linguistic styles of the language is identified according to a subset of a set of word-style associations related to the language and independent of the subject matter domain. A first weight is assigned to a first linguistic style and a second weight to a second linguistic style from the set of linguistic styles. A first intention information is mapped to the first style using a first style-intention rule, and a second intention information to the second style using a second style-intention rule. A complete grammatical construct in the subset is tagged with the first intention information responsive to a weight associated with the first intention information exceeding an intention selection threshold.

US Patent:

20160162788, Jun 9, 2016

Filed:

Dec 8, 2014

Appl. No.:

14/564040

Inventors:

- Armonk NY, US
- Houston TX, US
- Austin TX, US
Meenakshi Nagarajan - San Jose CA, US
William Scott Spangler - San Martin CA, US
Ioana R. Stanoi - Bronx NY, US
Anbu Karani Adikesavan - Houston TX, US
Benjamin J. Bachman - Houston TX, US
Lawrence A. Donehower - Houston TX, US
Olivier Lichtarge - Houston TX, US
Sam J. Regenbogen - Houston TX, US
Angela D. Wilkins - Houston TX, US
Curtis R. Pickering - Houston TX, US

Assignee:

International Business Machines Corporation - Armonk NY
Baylor College of Medicine - Houston TX
The Board of Regents, The University of Texas System - AUSTIN TX

International Classification:

G06N 5/02
G06F 9/54
G06N 99/00

Abstract:

A method, system, and computer program product for event detection using roles and relationships of entities are provided in the illustrative embodiments. A training event and a set of entities participating in the training event are identified in a training data. For a first entity in the set of entities, a first role occupied by the entity in the event is determined. A behavior attribute is assigned to the first role. A relationship of the first role with a second role corresponding to a second entity in the set of entities is determined. An event rule is constructed to detect an event corresponding to the training event in new data and comprising a plurality of roles, behavior attributes, and the relationship. The plurality of roles includes the first role and the second role, and the plurality of behavior attributes includes the behavior attribute assigned to the first role.

US Patent:

20150359840, Dec 17, 2015

Filed:

Sep 3, 2015

Appl. No.:

14/844007

Inventors:

- Austin TX, US
- Houston TX, US
Nick V. Grishin - Dallas TX, US
Lisa N. Kinch - Dallas TX, US
Olivier Lichtarge - Houston TX, US
Angela D. Wilkins - Houston TX, US

Assignee:

BAYLOR COLLEGE OF MEDICINE - Houston TX
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM - Austin TX

International Classification:

A61K 38/08
C07K 7/06

Abstract:

An autophagy-inducing compound comprises an autophagy-inducing peptide comprising Beclin 1 peptides immediately N- and C-terminally flanked by moieties Rand R, respectively, wherein up to six of said peptide residues may be substituted, Rand Rdo not naturally flank the Belclin 1 residues, and F270 and F274 are optionally substituted and optionally linked. The compounds may be used to induce autophagy.