Sarit Larisch - Zichron-Yaakov, IL Seong-Jin Kim - Bethesda MD, US Robert Lechleider - Bethesda MD, US Anita Roberts - Bethesda MD, US Youngsuk Yi - Redwood City CA, US
Assignee:
The Government of the United States of America - Rockville MD
The invention provides a newly identified and isolated nucleotide sequence encoding a polypeptide referred to in the present application as ARTS, for Apoptosis Related protein in the TGF- Signaling pathway.
Inhibition Of Smad3 To Prevent Fibrosis And Improve Wound Healing
Anita Roberts - Bethesda MD, US Gillian Ashcroft - Lancashire, GB Angelo Russo - Bethesda MD, US James Mitchell - Damascus MD, US
International Classification:
A61K048/00 A61K038/17
US Classification:
514/044000, 514/012000
Abstract:
The invention is related to modulation of Smad3 expression to prevent fibrosis and improve wound healing. Aspects of the invention, for example, include approaches to improve wound healing and/or reduce or prevent fibrosis by inhibiting Smad3. Embodiments described herein also include approaches to identify componds that modulate Smad3 expression and the preparation of pharmaceuticals comprising said compounds.
Use Of Smad3 Inhibitor In The Treatment Of Fibrosis Dependent On Epithelial To Mesenchymal Transition As In The Eye And Kidney
Anita Roberts - Bethesda MD, US Gillian Ashcroft - Lancashire, GB Angelo Russo - Bethesda MD, US James Mitchell - Damascus MD, US
International Classification:
A61K 48/00 A61K 38/54
US Classification:
514002000, 514044000
Abstract:
The invention is related to modulation of Smad3 expression to prevent fibrosis and improve wound healing. Aspects of the invention, for example, include approaches to improve wound healing and/or reduce or prevent fibrosis by inhibiting Smad3. Embodiments described herein also include approaches to identify componds that modulate Smad3 expression and the preparation of pharmaceuticals comprising said compounds.
Michael B. Sporn - Bethesda MD Anita B. Roberts - Bethesda MD Richard K. Assoian - Dobbs Ferry NY Charles A. Frolik - Indianapolis IN
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
C07K 1500
US Classification:
530399
Abstract:
A composition for the promotion of cell proliferation and tissue repair in animals having as active ingredients a TGF-. beta. which is activated by either a TGF-. alpha. or an EGF or both; and methods for administration. As another embodiment these active ingredients can be admixed with other (secondary) growth factors.
Compositions Of Transforming Growth Factor .Beta.(Tgf-.Beta.) Which Promotes Wound Healing And Methods For Their Use
Michael B. Sporn - Bethesda MD Anita B. Roberts - Bethesda MD
Assignee:
The United States of America as represented by the Department of Health and Human Services - Washington DC
International Classification:
A61K 3818 C07K 14495
US Classification:
514 2
Abstract:
A composition for the promotion of cell proliferation and tissue repair in animals having as active ingredients a TGF-. beta. which is activated by either a TGF-. alpha. or an EGF or both; and methods for administration. As another embodiment these active ingredients can be admixed with other (secondary) growth factors.
Promotion Of Cell Proliferation By Use Of Transforming Growth Factor Beta (Tgf-.Beta.)
Michael B. Sporn - Bethesda MD Anita B. Roberts - Bethesda MD
Assignee:
The United States of America as represented by the Secretary of the Department of Health and Human Services - Washington DC
International Classification:
A61K 3818 C07K 14495
US Classification:
514 2
Abstract:
A composition for the promotion of cell proliferation and tissue repair in animals having as active ingredients a TGF-. beta. which is activated by either a TGF-. alpha. or an EGF or both; and methods for administration. As another embodiment these active ingredients can be admixed with other (secondary) growth factors.