Ann E Horan

US Patent:

56188099, Apr 8, 1997

Filed:

Feb 27, 1995

Appl. No.:

8/394937

Inventors:

Ellen B. Barrabee - Fanwood NJ
Ann C. Horan - Summit NJ
Frank A. Gentile - Wayne NJ
Mahesh G. Patel - Verona NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07D49822
A61K 3155

US Classification:

514211

Abstract:

N-alkanoyl derivatives of staurospodne represented by the formula I ##STR1## wherein R. sub. a and R. sub. b are each H or ##STR2## wherein R. sub. 1 and R. sub. 2 are independently H or --OH or --OCH. sub. 3 and R. sub. 3 is OH, NHCH. sub. 3, NCH COCH. sub. 3 or NHCOCH. sub. 3 and R. sub. 4 is OH or H and, stereochemical isomers thereof with the provisos that (1) when R. sub. a and R. sub. b. dbd. A, and R. sub. 1. dbd. H. sub. 2 or OH R. sub. 3 is not NHCH. sub. 3 ; (2) when R. sub. a and R. sub. b. dbd. B, then R. sub. 1. dbd. R. sub. 4. dbd. OH or R. sub. 1. dbd. R. sub. 4. dbd. H; (3) when R. sub. a. dbd. R. sub. b. dbd. H R. sub. 1. dbd. --OCH. sub. 3, and (4) when R. sub. a and R. sub. b. dbd. A, and R. sub. 1. dbd. H and R. sub. 2. dbd. OCH. sub. 3, then R3 is not and ##STR3## pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti-inflammatory effect in warm-blood animals such as man are disclosed.

US Patent:

51263505, Jun 30, 1992

Filed:

Jun 13, 1990

Appl. No.:

7/537383

Inventors:

Raymond Cooper - Yardley PA
Ann C. Horan - Summit NJ
Joseph A. Marquez - Montclair NJ
Mahesh G. Patel - Verona NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31435
C07D49116
A23K 117
C17P 1718

US Classification:

514279

Abstract:

A compound represented by the formula I: ##STR1## wherein R. sub. 1 and R. sub. 2 are independently hydrogen or (C. sub. 2 -C. sub. 10) alkanoyl in substantially chemically pure form, and pharmaceutical compositions thereof are disclosed.

US Patent:

45979685, Jul 1, 1986

Filed:

Jun 21, 1984

Appl. No.:

6/623266

Inventors:

Jay A. Waitz - Warren NJ
Mahesh G. Patel - Verona NJ
Joseph A. Marquez - Montclair NJ
Manohar G. Kalyanpur - Winchester MA
Ann C. Horan - Summit NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 3574
C12P 106

US Classification:

424118

Abstract:

The antibiotic 13-384 complex is elaborated by a new variety of Micromonospora carbonacea; namely Micromonospora carbonacea var africana NRRL 15099.