Ann Michelle Mccormick

US Patent:

20100204055, Aug 12, 2010

Filed:

Dec 5, 2009

Appl. No.:

12/631824

Inventors:

Henry Hepburne-Scott - Encinitas CA, US
Ann McCormick - Encinitas CA, US

International Classification:

C40B 30/04
C40B 40/10

US Classification:

506 9, 506 18

Abstract:

Autoantibodies in biological samples such as serum can result from changes to biomolecules (e.g., proteins, polysaccharides, and lipids) that are associated with disease. Such autoantibodies are useful biomarkers because they frequently appear early in disease and are readily accessible, particularly in biological fluids such as blood and serum. CT antigens are particularly useful for detecting autoantibodies correlated with cancer. Numerous population-based profiles for pluralities of different autoantibody species, at least some of which are specifically reactive with CT antigens, allow for simultaneous assessment of multiple disease-associated analytes is a single test, which can be more effective in diagnostics and drug development than individual profiles. The instant invention provides autoantibody detection array devices that include a plurality of independently selected autoantibody-reactive reagent species, such as full-length CT antigens or the antigenic portions thereof, disposed on a substrate. Such arrays can be used to screen biological samples taken from patients or other subjects for diagnostic, drug development, and other applications.