Tesfaye Biftu - Freehold NJ, US Xiaoxia Qian - New York NY, US Ann E. Weber - Scotch Plains NJ, US Danqing Dennis Feng - Branchburg NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D 243/08 A61K 31/551 A61P 3/10
US Classification:
514218, 540492
Abstract:
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Piperidino Pyrimidine Dipeptidyl Peptidase Inhibitors For The Treatment Of Diabetes
The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Hexahydrodiazepinones As Dipeptidyl Peptidase-Iv Inhibitors For The Treatment Or Prevention Of Diabetes
Tesfaye Biftu - Freehold NJ, US Danqing Dennis Feng - Branchburg NJ, US Ann E. Weber - Scotch Plains NJ, US
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D 243/08 A61K 31/551 A61P 3/10
US Classification:
514218, 514221, 540492, 540500
Abstract:
The present invention is directed to hexahydrodiazepinone compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Aminocyclohexanes As Dipeptidyl Peptidase-Iv Inhibitors For The Treatment Or Prevention Of Diabetes
The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Aminotetrahydropyrans As Dipeptidyl Peptidase-Iv Inhibitors For The Treatment Or Prevention Of Diabetes
Tesfaye Biftu - Freehold NJ, US Ann E. Weber - Scotch Plains NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07D 251/00
US Classification:
544180
Abstract:
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Aminocyclohexanes As Dipeptidyl Peptidase-Iv Inhibitors For The Treatment Or Prevention Of Diabetes
Tesfaye Biftu - Freehold NJ, US Jason Cox - East Windsor NJ, US Danqing Feng - Branchburg NJ, US Anthony Mastracchio - Princeton NJ, US Xiaoxia Qian - New York NY, US Ann E. Weber - Scotch Plains NJ, US
The present invention is directed to novel substituted aminocyclohexanes of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Substitued [1,2,4]Triazolo[1,5-A]Pyrazines As Dipeptidyl Peptidase-Iv Inhibitors For The Treatment Or Prevention Of Diabetes
Tesfaye Biftu - Freehold NJ, US Ping Chen - Edison NJ, US Danqing Feng - Green Brook NJ, US Ann E. Weber - Scotch Plains NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/50
US Classification:
51425505, 544350, 549424
Abstract:
The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Aminopiperidines As Dipeptidyl Peptidase-Iv Inhibitors For The Treatment Or Prevention Of Diabetes
The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Name / Title
Company / Classification
Phones & Addresses
Ann Weber Executive Director Of Medicinal Chemistry
Merck & Co., Inc. Noncommercial Research Organizations
Saint Francis of Assisi School Los Angeles CA 1949-1953, Micheltorena Elementary School Los Angeles CA 1953-1953, Thomas Starr King Junior High School Los Angeles CA 1954-1956
Community:
Anthony Tony, Victor Ornelas
Biography:
Life
Retired from Pacific Bell in 1996, was a customer service rep for over 20 years...
San Francisco, CAPrincipal at Whiteshirt Design Past: Creative Director at LeapFrog, Creative Director at Ubisoft Entertainment A Creative Director and Designer with extensive experience delivering strategic, integrated brand campaigns from concept to execution. Professional and cool... A Creative Director and Designer with extensive experience delivering strategic, integrated brand campaigns from concept to execution. Professional and cool under fire, with a broad range of creative, management and technical skills.
An early adopter with a passion for design, music and film, my...
Gerry and Ann Weber were recognized by the Dog Obedience Committee, chaired by Frank Mams, for their many years of volunteer service directing the eight-week dog training school held each spring at Camp Pioneer. The High Riders 4-H club presented certificates to Claire St. Peter, Erica Janes and Lis
Ann Weber, chief medical officer at NFRMC, said the hospital has a timeline of implementations required under the Affordable Care Act that is around 4 feet long. But Weber said many of the requirements have already been implemented.