Anna R Hazlewood

US Patent:

8188283, May 29, 2012

Filed:

Mar 12, 2010

Appl. No.:

12/722642

Inventors:

Hayley Binch - Encinitas CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Sara S. Hadida Ruah - La Jolla CA, US
Jinglan Zhou - San Diego CA, US
Anna Hazlewood - San Diego CA, US
Lev T. D. Fanning - San Marcos CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07K 1/00

US Classification:

546123

Abstract:

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

US Patent:

8242149, Aug 14, 2012

Filed:

Mar 13, 2006

Appl. No.:

11/374334

Inventors:

Sara Hadida Ruah - La Jolla CA, US
Anna Hazlewood - San Diego CA, US
Peter Grootenhuis - San Diego CA, US
Jinglan Zhou - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A01N 43/64
A01N 43/36
A01N 43/38
A61K 31/41
A61K 31/40

US Classification:

514359, 514408, 514410, 514412

Abstract:

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

US Patent:

8314256, Nov 20, 2012

Filed:

Oct 6, 2006

Appl. No.:

11/544785

Inventors:

Sara Hadida Ruah - La Jolla CA, US
Anna Hazlewood - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 209/12
A61K 31/405

US Classification:

548493, 514419

Abstract:

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

US Patent:

8324242, Dec 4, 2012

Filed:

Jan 9, 2009

Appl. No.:

12/351447

Inventors:

Sara Hadida Ruah - La Jolla CA, US
Anna Hazlewood - San Diego CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Fredrick Van Goor - San Diego CA, US
Ashvani Singh - San Diego CA, US
Jinglan Zhou - San Diego CA, US
Jason McCartney - Cardiff-by-the-Sea CA, US

Assignee:

Vertex Pharmaceutical Incorporated - Cambridge MA

International Classification:

A61K 31/4709
A61P 3/06
A61P 43/00
A61P 3/10
A61P 35/00
A61P 25/28
A61P 25/16

US Classification:

514312

Abstract:

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

US Patent:

8410132, Apr 2, 2013

Filed:

Apr 23, 2012

Appl. No.:

13/453193

Inventors:

Hayley Binch - Encinitas CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Sara S Hadida Ruah - La Jolla CA, US
Jinglan Zhou - San Diego CA, US
Anna Hazlewood - San Diego CA, US
Lev T. D. Fanning - San Marcos CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/4375
A61P 3/10
A61P 5/18
A61P 11/00
A61P 25/16
A61P 25/28
C07D 471/04
C12N 5/00
C07K 1/00

US Classification:

514300, 435375, 530402, 546123

Abstract:

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

US Patent:

8614327, Dec 24, 2013

Filed:

Nov 30, 2012

Appl. No.:

13/690924

Inventors:

Lev T. D. Fanning - San Marcos CA, US
Mehdi Michel Djamel Numa - San Diego CA, US
Hayley Binch - Encinitas CA, US
Dennis Hurley - San Marcos CA, US
Jinglan Zhou - San Diego CA, US
Sara S. Hadida Ruah - La Jolla CA, US
Anna Hazlewood - San Diego CA, US
Alina Silina - San Diego CA, US
Rajendran Vairagoundar - Kalamazoo MI, US
Fredrick Van Goor - San Diego CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Martyn Botfield - Concord MA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

C07D 215/38
A61K 31/04

US Classification:

546159, 514312

Abstract:

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

US Patent:

8629162, Jan 14, 2014

Filed:

Oct 8, 2012

Appl. No.:

13/647034

Inventors:

Anna Hazlewood - San Diego CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Fredrick Van Goor - San Diego CA, US
Ashvani Singh - San Diego CA, US
Jinglan Zhou - San Diego CA, US
Jason McCartney - Cardiff by the Sea CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A61K 31/04

US Classification:

514312

Abstract:

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

US Patent:

8642609, Feb 4, 2014

Filed:

Jun 7, 2004

Appl. No.:

10/862909

Inventors:

Lewis R. Makings - Encinitas CA, US
Ashavini K. Singh - San Diego CA, US
Mark T. Miller - San Diego CA, US
Sarah S. Hadida Ruah - La Jolla CA, US
Peter D. J. Grootenhuis - San Diego CA, US
Matthew Hamilton - Wallingford PA, US
Anna Ruth Hazlewood - San Diego CA, US
Liming Huang - San Diego CA, US

Assignee:

Vertex Pharmaceuticals Incorporated - Cambridge MA

International Classification:

A01N 43/54
A61K 31/517
C07D 239/72
C07D 401/00

US Classification:

5142662, 544283, 544284

Abstract:

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.