Anna Vetrano

US Patent:

7105511, Sep 12, 2006

Filed:

Aug 19, 2004

Appl. No.:

10/922300

Inventors:

Jeffrey D. Laskin - Piscataway NJ, US
Ned Heindel - Easton PA, US
Diane Heck - Rumson NJ, US
Anna Marie Vetrano - North Brunswick NJ, US
Christophe Guillon - Bethlehem PA, US
Peter DeMatteo - Allentown PA, US

Assignee:

University of Medicine and Dentistry of New Jersey - New Brunswick NJ
Rutgers, the State University - New Brunswick NJ
Lehigh University - Bethlehem PA

International Classification:

C07D 513/04
A61K 31/542
A61P 35/00

US Classification:

5142228, 544 10

Abstract:

Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.

US Patent:

7598238, Oct 6, 2009

Filed:

Jul 28, 2006

Appl. No.:

11/495948

Inventors:

Jeffrey D. Laskin - Piscataway NJ, US
Ned Heindel - Easton PA, US
Diane Heck - Rumson NJ, US
Anna Marie Vetrano - North Brunswick NJ, US
Christophe Guillon - Bethlehem PA, US
Peter DeMatteo - Allentown PA, US

Assignee:

University of Medicine and Dentistry of New Jersey - New Brunswick NJ
Rutgers, the State University - New Brunswick NJ
Lehigh University - Bethlehem PA

International Classification:

C07D 513/04
A61K 31/542

US Classification:

5142228, 544 10

Abstract:

Fused-ring triazole compounds which inhibit proliferation of cells and exhibit a unique and intense fluorescence are provided. Also provided are methods for synthesizing these compounds and methods for using these compounds to inhibit cell proliferation and infection and to label and fluorescently detect selected molecules.

US Patent:

20030228648, Dec 11, 2003

Filed:

Jun 7, 2002

Appl. No.:

10/165841

Inventors:

Jeffrey Laskin - Piscataway NJ, US
Anna Vetrano - North Brunswick NJ, US
Diane Heck - Rumson NJ, US

International Classification:

C12Q001/26
C12Q001/30
A61K038/44
C12P007/22

US Classification:

435/025000, 435/156000, 424/094400, 435/262500

Abstract:

A catalase-dependent enzymatic oxidation process wherein a substrate to be oxidized is contacted with catalase in the absence of hydrogen peroxide is provided. Also provided are methods for using this process in a variety of biomedical, clinical and diagnostic applications as well as industrial processes. A method for stimulating the enzymatic oxidation process by treatment with ultraviolet light and uses for this method are also provided.

US Patent:

20140243381, Aug 28, 2014

Filed:

Feb 22, 2013

Appl. No.:

13/774231

Inventors:

UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - , US
Diane E. Heck - Rumson NJ, US
Geraldine Guillon - Macungie PA, US
Thomas Finetti - Livingston NJ, US
Angela Hunter - Mickleton NJ, US
Christophe Guillon - Macungie PA, US
Robert D. Rapp - Laurel Dale PA, US
Anna T. Vetrano - Hamilton NJ, US
Ned D. Heindel - Easton PA, US

Assignee:

UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY - Somerset NJ

International Classification:

C07D 409/04
C07D 409/12
C07D 405/04
C07D 409/14
C07D 405/14

US Classification:

514384, 5482638

Abstract:

Nitric oxide biosynthesis-inhibiting anti-inflammatory and anti-microbial compounds of Formula (3) and Formula (4) wherein R1 and R2 are independently selected from optionally substituted thienyl, optionally substituted furyl, optionally substituted —CH═CH-thienyl and optionally substituted provided that R2 is substituted with as nitro groupTreatment methods utilizing the compounds, and methods of synthesis of the compounds are also disclosed.