Anne Nell Andrews

US Patent:

20210140917, May 13, 2021

Filed:

Apr 11, 2019

Appl. No.:

17/045842

Inventors:

- Oakland CA, US
Anne M. Andrews - Los Angeles CA, US
Kevin M. Cheung - Los Angeles CA, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA

International Classification:

G01N 27/414
C12Q 1/6827

Abstract:

A method of detecting and/or discriminating mismatched or complementary nucleic acids using a field-effect transistor (FET). The FET comprises source and drain electrodes formed on substrate and separated by a channel that includes a thin semiconducting film. One or more nucleic acid molecules are immobilized to thin semiconducting film. The FET includes a gate electrode in contact with solution containing the sample (or located on the surface of the device). Samples possibly containing target nucleic acid are exposed to the FET of the biosensor device and current response is measured after samples containing target nucleic acid have been exposed to the FET of the biosensor device. Measured current response in the FET is used to detect and/or discriminate whether target nucleic acid is present as well as complementary or mismatched. Measured current response may also be used to differentiate among different mismatches.

US Patent:

20190187040, Jun 20, 2019

Filed:

Feb 25, 2019

Appl. No.:

16/284861

Inventors:

- Oakland CA, US
Anne M. Andrews - Los Angeles CA, US
Andrea L. Bertozzi - Santa Monica CA, US
Stanley J. Osher - Pacific Palisades CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 15/08
G01N 15/06
G01N 15/14

Abstract:

Systems and methods of fabricating and functionalizing patterned nanowire probes that are stable under fluid reservoir conditions and have imageable patterns are provided. Additional embodiments possess functionalized molecular groups to collect content data of desired chemical species from a fluid reservoir in order to detect even highly dilute quantities of the desire chemical species in the reservoir. Optical imaging and deconstruction methods and systems are also provided that are capable of determining the distribution of nanowires of a particular pattern to determine the mixing between or leakage from fluid reservoirs.

US Patent:

20170052104, Feb 23, 2017

Filed:

May 5, 2015

Appl. No.:

15/308049

Inventors:

- Oakland CA, US
Anne M. Andrews - Los Angeles CA, US
Andrea L. Bertozzi - Santa Monica CA, US
Stanley J. Osher - Pacific Palisades CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G01N 15/08
G01N 15/06
G01N 15/14

Abstract:

Systems and methods of fabricating and functionality patterned nanowire probes that are stable under fluid reservoir conditions and have imageable contrast are provided. Optical imaging and deconstruction methods and systems are also provided that are capable of determining the distribution of nanowires of a particular pattern to determine the mixing between or leakage from fluid reservoirs.