Anne E Bailey

US Patent:

6441189, Aug 27, 2002

Filed:

Dec 13, 2001

Appl. No.:

10/020326

Inventors:

Anne E. Bailey - Beach Park IL
David R. Hill - Gurnee IL
Chi-nung W. Hsiao - Libertyville IL
Ravi Kurukulasuriya - Gurnee IL
Steve Wittenberger - Mundelein IL
Todd McDermott - Oak Park IL
Maureen A. McLaughlin - Gurnee IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D26306

US Classification:

548232

Abstract:

The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

US Patent:

20020019539, Feb 14, 2002

Filed:

Mar 30, 2001

Appl. No.:

09/821887

Inventors:

Anne Bailey - Beach Park IL, US
David Hill - Gurnee IL, US
Chi-Nung Hsiao - Libertyville IL, US
Ravi Kurukulasuriya - Gurnee IL, US
Steve Wittenberger - Mundelein IL, US
Todd McDermott - Oak Park IL, US
Maureen McLaughlin - Gurnee IL, US

International Classification:

C07D263/20
C07D233/32

US Classification:

548/225000, 548/323500

Abstract:

The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.

US Patent:

6211395, Apr 3, 2001

Filed:

Jun 13, 2000

Appl. No.:

9/592909

Inventors:

Daniel J. Plata - Wadsworth IL
Steven A. King - Gurnee IL
Frederick A. Plagge - Port Washington WI
Anne E. Bailey - Waukegan IL
Louis Seif - Buffalo Grove IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07C30966

US Classification:

558 49

Abstract:

The invention relates to a process of preparing a chiral compound of the formula: ##STR1## wherein R. sub. 1 is selected from the group consisting of hydrogen and lower alkyl, and R. sub. 2 and R. sub. 2' are the same, and R. sub. 2 and R. sub. 2' are selected from a group consisting of hydrogen and primary alkyl, or R. sub. 2 and R. sub. 2' taken together form a C. sub. 3 to C. sub. 6 cycloalkyl, comprising the steps of chirally reducing a. beta. -keto ester to afford a. beta. -hydroxy ester, activating the. beta. -hydroxy ester by treatment with a sulfonic acid or a derivative thereof to provide an activated compound having sulfonate leaving group, displacing the sulfonate leaving group with an azido moiety, or treating the activated compound with an alkylamine, deprotecting and cyclizing to afford a pyrrolidinone, and reducing the pyrrolidinone to afford a stereoisomerically preferred 3-aminopyrrolidine derivative.

US Patent:

61979740, Mar 6, 2001

Filed:

Oct 25, 1999

Appl. No.:

9/426237

Inventors:

Daniel J. Plata - Wadsworth IL
Steven A. King - Gurnee IL
Frederick A. Plagge - Port Washington WI
Anne E. Bailey - Waukegan IL
Louis Seif - Buffalo Grove IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C07D20714
C07D20954

US Classification:

548408

Abstract:

The invention relates to a process of preparing a chiral compound of the formula: ##STR1## wherein R. sub. 1 is selected from the group consisting of hydrogen and lower alkyl, and R. sub. 2 and R. sub. 2' are the same, and R. sub. 2 and R. sub. 2' are selected from a group consisting of hydrogen and primary alkyl, or R. sub. 2 and R. sub. 2' taken together form a C. sub. 3 to C. sub. 6 cycloalkyl, comprising the steps of chirally reducing a. beta. -keto ester to afford a. beta. -hydroxy ester, activating the. beta. -hydroxy ester by treatment with a sulfonic acid or a derivative thereof to provide an activated compound having sulfonate leaving group, displacing the sulfonate leaving group with an azido moiety, or treating the activated compound with an alkylamine, deprotecting and cyclizing to afford a pyrrolidinone, and reducing the pyrrolidinone to afford a stereoisomerically preferred 3-aminopyrrolidine derivative.