Anne E Strouse

US Patent:

20130040302, Feb 14, 2013

Filed:

Jul 11, 2012

Appl. No.:

13/546365

Inventors:

Thomas J. Burke - Madison WI, US
Michael Miller - Madison WI, US
Michael McLachlan - Verona WI, US
Sarah Jane Dickerson - Madison WI, US
Anne Strouse - Madison WI, US

International Classification:

C12N 15/87
C12Q 1/68
G01N 27/72
C12Q 1/04
C12N 15/90
G01N 21/64

US Classification:

435 612, 435465, 435456, 435462, 435463, 435 34, 435 61

Abstract:

Methods for producing engineered induced pluripotent stem (iPS) cells are provided comprising introducing a first nucleic acid into somatic cells for integration into their genome and reprogramming the cells to produce engineered iPS cells having the nucleic acid integrated into their genome. For example, in certain aspects the cells are reprogrammed by introduction of a genetic element that expresses one or more reprogramming factor and culturing of the cells under conditions sufficient to produce reprogrammed cells.

US Patent:

20220251516, Aug 11, 2022

Filed:

Jun 15, 2020

Appl. No.:

17/619096

Inventors:

- Madison WI, US
- Valhalla NY, US
Sarah BURTON - Madison WI, US
Madelyn GOEDLAND - Madison WI, US
Michael McLACHLAN - Madison WI, US
Abbey MUSINSKY - Madison WI, US
Kwi Hye KIM - Madison WI, US
Michael HANCOCK - Madison WI, US
Makiko OHSHIMA - Madison WI, US
Anne STROUSE - Madison WI, US
Sarah DICKERSON - Madison WI, US

Assignee:

FUJIFILM Cellular Dynamics, Inc. - Madison WI
FUJIFILM Holdings America Corporation - Valhalla NY

International Classification:

C12N 5/074
C12N 5/00

Abstract:

The present disclosure provides methods of producing progenitor cells from induced pluripotent stem cells, wherein the progenitor cells comprise endothelial cells, pericytes, brain microvascular endothelial cells (BMECs), mesenchymal stem cells (MSCs), hematopoietic precursor cells (HPCs), microglia or neural precursor cells (NPCs).

US Patent:

20180179496, Jun 28, 2018

Filed:

Oct 5, 2017

Appl. No.:

15/725931

Inventors:

- Madison WI, US
Anne STROUSE - Madison WI, US
Sarah BURTON - Madison WI, US
Christie MUNN - Madison WI, US
Bradley SWANSON - Madison WI, US

International Classification:

C12N 5/078
C12N 5/0783
C12N 5/071
C12N 5/079

Abstract:

Provided herein are methods for the efficient in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells with disruption of the MeCP2 gene into various erythroid, myeloid, lymphoid, or endoderm lineages, particularly mature erythrocytes. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the precursor cells.

US Patent:

20160281063, Sep 29, 2016

Filed:

Feb 23, 2016

Appl. No.:

15/051541

Inventors:

- Madison WI, US
Michael MILLER - Madison WI, US
Michael McLACHLAN - Verona WI, US
Sarah Jane DICKERSON - Madison WI, US
Anne STROUSE - Madison WI, US

Assignee:

Cellular Dynamics International, Inc. - Madison WI

International Classification:

C12N 5/074
C12N 15/90

Abstract:

Methods for producing engineered induced pluripotent stem (iPS) cells are provided comprising introducing a first nucleic acid into somatic cells for integration into their genome and reprogramming the cells to produce engineered iPS cells having the nucleic acid integrated into their genome. For example, in certain aspects the cells are reprogrammed by introduction of a genetic element that expresses one or more reprogramming factor and culturing of the cells under conditions sufficient to produce reprogrammed cells.