Charles Baker-Glenn - Puckeridge, GB Daniel Jon Burdick - Burlingame CA, US Mark Chambers - St. Neots, GB Bryan K. Chan - Burlingame CA, US Huifen Chen - Burlingame CA, US Anthony Estrada - San Carlos CA, US Daniel Shore - San Francisco CA, US Zachary Sweeney - Redwood City CA, US Shumei Wang - Foster City CA, US Guiling Zhao - San Mateo CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 31/505 C07D 239/28
US Classification:
514269, 544330, 514272
Abstract:
Compounds of the formula I:.
Compounds And Their Administration For Treating A Neurodegenerative Disease As Well As A Method For Identifying A Compound Capable Of Inhibiting A Kinase, Such As Lrrk
Bryan K. Chan - South San Francisco CA, US Huifen Chen - South San Francisco CA, US Anthony Estrada - South San Francisco CA, US Daniel Shore - South San Francisco CA, US Zachary Sweeney - Emeryville CA, US Edward Giles McIver - London, GB
Assignee:
Medical Research Council Technology - London Genentech, Inc. - South San Francisco CA
The present invention relates to substituted pyrazolopyridine compounds, and pharmaceutically acceptable salts or esters thereof. The present invention further relates to therapeutic uses of pharmaceutical compositions comprising the substituted pyrazolopyridine compounds, for example, in cancer and neurodegenerative diseases.
Pyrazole Aminopyrimidine Derivatives As Lrrk2 Modulators
Charles Baker-Glenn - St. Neots, GB Daniel Jon Burdick - Burlingame CA, US Mark Chambers - Puckeridge, GB Bryan K. Chan - San Carlos CA, US Huifen Chen - Burlingame CA, US Anthony Estrada - San Carlos CA, US Zachary Kevin Sweeney - Redwood City CA, US
Philippe Bergeron - San Mateo CA, US Frederick Cohen - San Francisco CA, US Anthony Estrada - San Carlos CA, US Michael F.T. Koehler - Palo Alto CA, US Kevin Hon Luen Lau - San Mateo CA, US Coung Ly - Daly City CA, US Joseph P. Lyssikatos - Piedmont CA, US Daniel Ortwine - San Ramon CA, US Zhonghua Pei - Burlingame CA, US Xianrui Zhao - San Mateo CA, US
Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
Daniel Jon Burdick - Burlingame CA, US Mark Chambers - Puckeridge, GB Bryan K. Chan - San Carlos CA, US Huifen Chen - Burlingame CA, US Anthony Estrada - San Carlos CA, US Daniel Shore - San Francisco CA, US Zachary Kevin Sweeney - Redwood City CA, US Shumei Wang - Foster City CA, US Guiling Zhao - Palo Alto CA, US
Assignee:
GENENTECH, INC. - South San Francisco CA
International Classification:
C07D 413/14 C07D 498/08 C07D 413/12
US Classification:
51421018, 5142358, 514275, 544122, 544324
Abstract:
Compounds of the formula I:or pharmaceutically acceptable salts thereof,
Fluorine-18 And Carbon-11 Labeled Radioligands For Positron Emission Tomography (Pet) Imaging For Lrrk2
Zachary Kevin Sweeney - Redwood City CA, US Bryan K. Chan - San Carlos CA, US Anthony Estrada - San Carlos CA, US
Assignee:
GENENTECH, INC. - South San Francisco CA
International Classification:
C07D 403/12 C07D 239/48
US Classification:
424 189, 424 181, 544122, 544323, 544324
Abstract:
A method for positron emission tomography (PET) imaging of LRRK2 in tissue of a subject, the method comprising: administering a compound of formula I, formula II or formula III, or a pharmaceutically acceptable salt thereof to the subject, wherein the compound includes at least one Cor Flabel thereon; allowing the compound to penetrate into the tissue of the subject; and collecting a PET image of the CNS or brain tissue of the subject
Daniel Jon Burdick - Burlingame CA, US Mark Chambers - Puckeridge, GB Bryan K. Chan - Burlingame CA, US Huifen Chen - Burlingame CA, US Anthony Estrada - San Carlos CA, US Daniel Shore - San Francisco CA, US Zachary Kevin Sweeney - Redwood City CA, US Shumei Wang - Foster City CA, US Guiling Zhao - Palo Alto CA, US
Compounds of the formula I:or pharmaceutically acceptable salts thereof,wherein A, X, R, R, Rand Rare as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
Jul 2014 to 2000 Adminstrative AssistantCSIX Connect - Peninsula
Apr 2012 to 2000 VolunteerAppleOne Staffing San Mateo County, CA Jun 2013 to Jun 2014 Data Entry Specialist, Proctor, and Customer Service RepresentativeStansbury Staffing San Mateo County, CA Mar 2013 to Apr 2014 Data Entry SpecialistRandstad Staffing San Mateo County, CA Jul 2012 to Dec 2012 Administrative AssistantWollborg / Michelson Personnel Services San Mateo County, CA May 2011 to Apr 2012 Administrative Clerk-Mid Pen HousingUniversity Custom Publishing Mountain View, CA Sep 1997 to Apr 2011 Customer Service Representative
Education:
Regional Occupational Program (ROP) Burlingame, CA 2006 to 2011 Certificate of Completion in Business Office CareersCollege of San Mateo 1987 to 1990 Associate of Science in Electronics Technology
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Microsoft Word and Excel, fax machines, copying machines, data entry,
Fresh & Easy Gilbert, AZ Apr 2009 to Oct 2013 Store managerWalgreens Tempe, AZ Apr 2007 to Apr 2009 Executive Assistant ManagerWalmart Mesa, AZ Jun 1997 to Apr 2007 Overnight support manager
Education:
Western New Mexico University Silver City, NM 1996 to 1998 2 year degree in Business management
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