Anthony Giordano - Phoenixville PA Gordon Donald Powers - Malvern PA Michael Alan Sturgess - Perkasie PA Ke Yang - Boothwyn PA
Assignee:
Message Pharmaceuticals - Malvern PA
International Classification:
C07D40102
US Classification:
546139, 548566, 5462764, 560 21, 564 50
Abstract:
The invention features screening assays for compounds that are potentially useful for treating or preventing a proliferative disease. The assays are based on contacting a candidate compound with a cell containing a nucleic acid including a HER2 regulatory element and a reporter sequence. In addition, the invention features compounds identified by the assays of the invention. The invention further features compounds structurally related to those identified by the screening assays. Finally, the invention features methods of treating or preventing a proliferative disease using the compounds of the invention.
Methods For Identifying Novel Nucleic Acid Regulatory Elements And Compounds That Affect The Regulation
Anthony Giordano - Phoenixville PA, US Paul S. Eder - Oreland PA, US Deborah Beach McGill - Wilmington DE, US Gregg Johannes - Exton PA, US
Assignee:
Message Pharmaceutical, Inc. - Malvern PA
International Classification:
C12Q 1/68 C12N 15/63 C12N 15/64
US Classification:
435 6, 435 71, 435 29, 435455
Abstract:
Described herein are methods for identifying novel nucleic acid regulatory elements and compounds that modulate the regulation of such elements. Also described herein are nucleic acid sequence identified as novel nucleic acid regulatory elements and host cells containing such nucleic acid regulatory elements in a vector.
Nucleic Acid Sequences And Methods For Identifying Compounds That Affect Rna/Rna Binding Protein Interactions And Mrna Functionality
Anthony Giordano - Phoenixville PA, US Asish Xavier - West Chester PA, US
International Classification:
C12Q001/68 C07H021/04 C12P019/34
US Classification:
435/006000, 435/091100, 536/023200
Abstract:
Disclosed herein are nucleic acid sequences and their optimized subfragments which are located in the mRNA untranslated regions of therapeutically-relevant genes. These sequences specifically bind RNA binding proteins (RBPs) and/or regulate the mRNA functionality. Also disclosed are methods of optimizing a subfragment of a parent nucleic acid sequence such that the RBP binding activity or mRNA functionality of the parent nucleic acid sequence is preserved in the optimized subfragment.
Nucleic Acid Sequences And Methods For Identifying Compounds That Affect Rna/Rna Binding Protein Interactions And Mrna Functionality
ANTHONY GIORDANO - Phoenixville PA, US ASHISH XAVIER - West Chester, IN
International Classification:
C12Q001/68
US Classification:
435/006000
Abstract:
Disclosed herein are nucleic acid sequences and their optimized subfragments which are located in the mRNA untranslated regions of therapeutically-relevant genes. These sequences specifically bind RNA binding proteins (RBPs) and/or regulate the mRNA functionality. Also disclosed are methods of optimizing a subfragment of a parent nucleic acid sequence such that the RBP binding activity or mRNA functionality of the parent nucleic acid sequence is preserved in the optimized subfragment.
Nucleic Acid Sequences And Methods For Identifying Compounds That Affect Rna/Rna Binding Protein Interactions And Mrna Functionality
Disclosed herein are nucleic acid sequences and their optimized subfragments which are located in the mRNA untranslated regions of therapeutically-relevant genes. These sequences specifically bind RNA binding proteins (RBPs) and/or regulate the mRNA functionality. Also disclosed are methods of optimizing a subfragment of a parent nucleic acid sequence such that the RBP binding activity or mRNA functionality of the parent nucleic acid sequence is preserved in the optimized subfragment.
Nucleic Acid Sequences And Methods For Identifying Compounds That Affect Rna/Rna Binding Protein Interactions And Mrna Functionality
Disclosed herein are nucleic acid sequences and their optimized subfragments which are located in the mRNA untranslated regions of therapeutically-relevant genes. These sequences specifically bind RNA binding proteins (RBPs) and/or regulate the mRNA functionality. Also disclosed are methods of optimizing a subfragment of a parent nucleic acid sequence such that the RBP binding activity or mRNA functionality of the parent nucleic acid sequence is preserved in the optimized subfragment.
Methods For Identifying Novel Nucleic Acid Regulatory Elements And Compounds That Affect The Regulation
Anthony Giordano - Phoenixville PA, US Paul Eder - Oreland PA, US Deborah McGill - Wilmington DE, US Gregg Johannes - Exton PA, US
International Classification:
C12Q 1/68 C12N 5/10 C12N 15/09
US Classification:
435006000, 435455000, 435325000
Abstract:
Described herein are methods for identifying novel nucleic acid regulatory elements and compounds that modulate the regulation of such elements. Also described herein are nucleic acid sequence identified as novel nucleic acid regulatory elements and host cells containing such nucleic acid regulatory elements in a vector.
Methods For Identifying Novel Nucleic Acid Regulatory Elements And Compounds That Affect The Regulation
Described herein are methods for identifying novel nucleic acid regulatory elements and compounds that modulate the regulation of such elements. Also described herein are nucleic acid sequence identified as novel nucleic acid regulatory elements and host cells containing such nucleic acid regulatory elements in a vector.
License Records
Anthony Giordano
License #:
34EI00515200 - Expired
Category:
Electrical Contractors
Issued Date:
Jan 4, 1975
Expiration Date:
Mar 31, 1985
Type:
Electrical Contractor
Anthony Giordano
License #:
LPR00007 - Expired
Category:
Podiatric Medicine
Issued Date:
Jun 19, 2000
Expiration Date:
Jun 19, 2001
Type:
Limited Podiatric Registration
Anthony M Giordano
License #:
LS128027A - Expired
Category:
Real Estate Commission
Type:
Cemetery Salesperson-Standard
Anthony Giordano
License #:
34EI00515200 - Expired
Category:
Electrical Contractors
Issued Date:
Jan 4, 1975
Expiration Date:
Mar 31, 1985
Type:
Electrical Contractor
Name / Title
Company / Classification
Phones & Addresses
Anthony Giordano Psychologist
Rhonda Allen Phd Offices and Clinics of Health Practitioners
641 Mcdonnell Dr, Tallahassee, FL 32310
Anthony Giordano Owner
Anthony Giordano Rev Radio Broadcast Station
2150 Cdbury Retirement Hm, Cherry Hill, NJ 08002
Anthony Giordano Principal
Ag Jamesons Inc Eating Place · Nonclassifiable Establishments
4439 Main St, Philadelphia, PA 19127
Anthony J. Giordano Principal
Anthony J. Giordano M.D., PC Medical Doctor's Office
Pediatric Health Care Associates PC 10 Centennial Dr STE L, Peabody, MA 01960 (978)5351110 (phone), (978)5355910 (fax)
Pediatric Health Care Associates PC 30 New Xing Rd STE 300, Reading, MA 01867 (781)4396744 (phone), (781)4396751 (fax)
Education:
Medical School SUNY Upstate Medical University Graduated: 2007
Procedures:
Destruction of Benign/Premalignant Skin Lesions Electrocardiogram (EKG or ECG) Hearing Evaluation Psychological and Neuropsychological Tests Pulmonary Function Tests Vaccine Administration
Dr. Giordano graduated from the SUNY Upstate Medical University in 2007. He works in Reading, MA and 1 other location and specializes in Pediatrics and Adolescent Medicine. Dr. Giordano is affiliated with Beverly Hospital and North Shore Medical Center Salem Campus.
Medical School Hahnemann University School of Medicine Graduated: 1976
Procedures:
Rhinoplasty Sinus Surgery Allergen Immunotherapy Allergy Testing Hearing Evaluation Inner Ear Tests Myringotomy and Tympanotomy Skull/Facial Bone Fractures and Dislocations Tonsillectomy or Adenoidectomy Tracheostomy Tympanoplasty
Dr. Giordano graduated from the Hahnemann University School of Medicine in 1976. He works in Richmond, VA and 1 other location and specializes in Otolaryngology. Dr. Giordano is affiliated with Johnston-Willis Hospital.
Dr. Giordano works in Shelby Township, MI and 1 other location and specializes in Podiatric Medicine. Dr. Giordano is affiliated with Beaumont Health System, Genesys Regional Medical Center, Henry Ford Macomb Hospital and Hurley Medical Center.
Northwell Health Physician PartnersLenox Hill Hospital Anesthesiology PLLC 100 E 77 St, New York, NY 10075 (212)4342878 (phone), (212)4344527 (fax)
Education:
Medical School University of Florida College of Medicine at Gainesville Graduated: 1986
Languages:
English
Description:
Dr. Giordano graduated from the University of Florida College of Medicine at Gainesville in 1986. He works in New York, NY and specializes in Anesthesiology. Dr. Giordano is affiliated with Lenox Hill Hospital.
"It's an incredible story because it's not true," Bedi's attorney, Anthony Giordano, said Tuesday. "For every dollar transferred, there is a written contract, and most of them were evaluated by Mr. Davidson's attorneys."