Anu A Sharma

US Patent:

7576221, Aug 18, 2009

Filed:

Jun 20, 2005

Appl. No.:

11/158574

Inventors:

Weibo Wang - Moraga CA, US
Paul A. Barsanti - Pleasant Hill CA, US
Yia Xia - Palo Alto CA, US
Rustum Boyce - Singapore, SG
Sabina Pecchi - Oakland CA, US
Nathan Brammeier - Walnut Creek CA, US
Megan C. Phillips - Walnut Creek CA, US
Kris Mendenhall - Concord CA, US
Kelly Wayman - San Rafael CA, US
Liana Marie Lagniton - Berkeley CA, US
Ryan Constantine - Salt Lake City UT, US
Hong Yang - Pleasant Hill CA, US
Elizabeth Mieuli - Oakland CA, US
Savithri Ramurthy - Walnut Creek CA, US
Elisa Jazan - Richmond CA, US
Anu Sharma - El Cerrito CA, US
Rama Jain - Fremont CA, US
Sharadha Subramanian - San Ramon CA, US
Paul A. Renhowe - Danville CA, US
Kenneth W. Bair - Oakland CA, US
David Duhl - Oakland CA, US
Annette Walter - Mill Valley CA, US
Tinya Abrams - Richmond CA, US
Kay Huh - San Mateo CA, US
Eric Martin - El Cerrito CA, US
Mark Knapp - Oakland CA, US
Vincent P. Le - San Francisco CA, US

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

A61K 31/4174
C07D 233/64

US Classification:

5483381, 514400

Abstract:

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:.

US Patent:

8318791, Nov 27, 2012

Filed:

Jun 5, 2009

Appl. No.:

12/455798

Inventors:

Weibo Wang - Moraga CA, US
Paul A. Barsanti - Pleasant Hill CA, US
Yia Xia - Palo Alto CA, US
Rustum Boyce - Singapore, SG
Sabina Pecchi - Oakland CA, US
Nathan Brammeier - Walnut Creek CA, US
Megan C. Phillips - Walnut Creek CA, US
Kris Mendenhall - Concord CA, US
Kelly Wayman - San Rafael CA, US
Liana Marie Lagniton - Berkeley CA, US
Ryan Constantine - Salt Lake City UT, US
Hong Yang - Pleasant Hill CA, US
Elizabeth Mieuli - Oakland CA, US
Savithri Ramurthy - Walnut Creek CA, US
Elisa Jazan - Richmond CA, US
Anu Sharma - El Cerrito CA, US
Rama Jain - Fremont CA, US
Sharadha Subramanian - San Ramon CA, US
Paul A. Renhowe - Danville CA, US
Kenneth W. Bair - Oakland CA, US
David Duhl - Oakland CA, US
Annette Walter - Mill Valley CA, US
Tinya Abrams - Richmond CA, US
Kay Huh - San Mateo CA, US
Eric Martin - El Cerrito CA, US
Mark Knapp - Oakland CA, US
Vincent P. Le - San Francisco CA, US

Assignee:

Novartis Vaccines and Diagnostics, Inc. - Emeryville CA

International Classification:

A61K 39/395
A61K 31/4178
A61K 31/427
A61K 31/5386
A61K 31/4174

US Classification:

514397, 514365, 5142305, 514400, 5142102, 4241331

Abstract:

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula:.

US Patent:

20080045528, Feb 21, 2008

Filed:

Apr 18, 2007

Appl. No.:

11/737069

Inventors:

James Sutton - Pleasanton CA, US
Marion Wiesmann - Brisbane CA, US
Weibo Wang - Moraga CA, US
Mika Lindvall - Oakland CA, US
Jiong Lan - Moraga CA, US
Savithri Ramurthy - Walnut Creek CA, US
Anu Sharma - El Cerrito CA, US
Elizabeth Mieuli - Stanford CA, US
Liana Klivansky - Oakland CA, US
William Lenahan - San Leandro CA, US
Susan Kaufman - Lafayette CA, US
Hong Yang - Foster City CA, US
Simon Ng - Walnut Creek CA, US
Keith Pfister - San Ramon CA, US
Allan Wagman - Belmont CA, US
Victoria Sung - San Francisco CA, US
Martin Sendzik - San Mateo CA, US

International Classification:

A61K 31/535
A61K 31/44
A61K 31/445
C07D 211/00
C07D 413/00
C07D 417/00
C07D 401/00
A61P 43/00
A61K 31/497

US Classification:

514233800, 514252160, 514318000, 514333000, 514338000, 544129000, 544360000, 546193000, 546256000, 546270100

Abstract:

Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

US Patent:

20100280006, Nov 4, 2010

Filed:

May 8, 2009

Appl. No.:

12/387946

Inventors:

James C. Sutton - Pleasanton CA, US
Marion Wiesmann - Brisbane CA, US
Weibo Wang - Moraga CA, US
Mika Lindvall - Oakland CA, US
Jiong Lan - Moraga CA, US
Savithri Ramurthy - Walnut Creek CA, US
Anu Sharma - El Cerrito CA, US
Elizabeth J. Mieuli - Stanford CA, US
Liana M. Klivansky - Oakland CA, US
William Lenahan - San Leandro CA, US
Susan Kaufman - Lafayette CA, US
Hong Yang - Foster City CA, US
Simon C. Ng - Walnut Creek CA, US
Keith Pfister - San Ramon CA, US
Allan S. Wagman - Belmont CA, US
Victoria Sung - San Francisco CA, US
Martin Sendzik - San Mateo CA, US

International Classification:

A61K 31/55
A61K 31/4439
A61K 31/4545
A61K 31/5377
A61K 31/444
A61K 31/496
A61K 31/497
A61K 31/4709
A61K 31/437
A61K 31/428
A61K 31/506
A61P 35/02
A61P 35/00
A61P 19/02
A61P 29/00
A61P 19/10
A61P 9/10
A61P 43/00
C12N 5/02

US Classification:

51421208, 514338, 514318, 5142338, 514333, 5142531, 51425505, 514312, 514300, 514256, 514275, 51425218, 435375

Abstract:

Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

US Patent:

20120225861, Sep 6, 2012

Filed:

Apr 23, 2012

Appl. No.:

13/453202

Inventors:

James C. Sutton - Pleasanton CA, US
Marion Wiesmann - Brisbane CA, US
Weibo Wang - Moraga CA, US
Mika Lindvall - Oakland CA, US
Jiong Lan - Moraga CA, US
Savithri Ramurthy - Walnut Creek CA, US
Anu Sharma - El Cerrito CA, US
Elizabeth J. Mieuli - Stanford CA, US
Liana M Klivansky - Oakland CA, US
William Lenahan - San Leandro CA, US
Susan Kaufman - Lafayette CA, US
Hong Yang - Foster City CA, US
Simon C. Ng - Walnut Creek CA, US
Keith Pfister - San Ramon CA, US
Allan S. Wagman - Belmont CA, US
Victoria Sung - San Francisco CA, US
Martin Sendzik - San Mateo CA, US

International Classification:

A61K 31/4439
C07D 413/14
A61K 31/4545
A61K 31/5377
C07D 417/14
A61P 35/02
A61P 35/00
A61P 19/10
A61P 19/02
A61P 9/10
A61P 13/12
C07D 413/12
A61K 31/55

US Classification:

51421208, 5462717, 514338, 546194, 514318, 544131, 5142338, 540524

Abstract:

Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

US Patent:

20130017196, Jan 17, 2013

Filed:

Sep 13, 2012

Appl. No.:

13/613977

Inventors:

Weibo Wang - Moraga CA, US
Paul A. Barsanti - Pleasant Hill CA, US
Yia Xia - Palo Alto CA, US
Rustum Boyce - New York NY, US
Sabina Pecchi - Oakland CA, US
Nathan Brammeier - Walnut Creek CA, US
Megan C. Phillips - Lake Orion MI, US
Kris Mendenhall - Concord CA, US
Kelly Wayman - San Rafael CA, US
Ryan Constantine - Salt Lake City UT, US
Hong Yang - Fremont CA, US
Elizabeth Mieuli - Redwood City CA, US
Savithri Ramurthy - Walnut Creek CA, US
Elisa Jazan - Siena, IT
Anu Sharma - El Cerrito CA, US
Rama Jain - Fremont CA, US
Sharadha Subramanian - San Ramon CA, US
Paul A. Renhowe - Danville CA, US
Kenneth W. Bair - Oakland CA, US
David Duhl - Oakland CA, US
Annette Walter - Mill Valley CA, US
Tinya Abrams - Richmond CA, US
Kay Huh - San Mateo CA, US
Eric Martin - El Cerrrito CA, US
Mark Knapp - Oakland CA, US
Vincent P. Le - San Francisco CA, US

International Classification:

A61K 31/4174
C07D 401/12
A61K 31/454
C07D 403/12
A61K 31/496
A61K 31/4439
C07D 405/12
A61K 31/4178
C07D 417/12
A61K 31/427
C07D 413/12
A61K 31/422
A61K 31/5377
C07D 498/10
A61P 35/00
A61K 31/4745
A61K 31/7068
A61K 39/395
A61K 33/24
A61K 31/664
A61P 35/02
C07D 233/64

US Classification:

4241331, 5483381, 514400, 5483385, 546210, 514326, 544370, 51425405, 5462751, 514341, 5483154, 514397, 5483127, 5483124, 548200, 514365, 5483147, 548248, 514378, 544139, 5142358, 5142365, 5142102, 544 71, 514283, 514 49, 51425218, 424649, 514110

Abstract:

The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds. The compounds of the invention have the following general formula: