Anuraag Renuka Singh Singh

US Patent:

20080255663, Oct 16, 2008

Filed:

Apr 13, 2007

Appl. No.:

11/735179

Inventors:

Esen K. Akpek - Baltimore MD, US
Gopalan V. Balaji - Kennett Square PA, US
Paul J. Fischer - Greenville DE, US
Thomas B. Schmiedel - Bear DE, US
Anuraag Singh - Newark DE, US

International Classification:

A61F 2/14

US Classification:

623 514

Abstract:

The present invention is an artificial cornea designed to restore vision in patients who are not candidates to receive a natural cornea transplant (allograft). The present device construction involves the use of a biocompatible, non-porous optic disk intimately bonded to one or more anchoring layers of porous polymeric material, and a unique sealing region which enhances sealing of the artificial cornea in the recipient's eye.

US Patent:

20210252194, Aug 19, 2021

Filed:

Jun 14, 2019

Appl. No.:

17/252036

Inventors:

- Newark DE, US
Paul J. Fischer - Wilmington DE, US
Thomas B. Schmiedel - Middletown DE, US
Anuraag Singh - Hockessin DE, US

International Classification:

A61L 27/56
A61L 27/16
A61L 27/34
A61L 27/44

Abstract:

A microporous biocomposite that is suitable for surgical implantation in an avascular environment is provided. The microporous biocomposite includes (1) a polymer scaffold having a thickness less than about 100 μm and nodal structures that extend to at least one surface of the polymer scaffold and (2) a hydrophilic coating on the polymer scaffold. In some embodiments, the porous scaffold is a microporous biomaterial with nodal structures that extend from a first surface to a second surface of the microporous biomaterial. The hydrophilic coating may be a node and fibril coating. The microporous biocomposite allows for the integration and sustained viability of epithelial cells on the surface thereof as well as tissue integration and the internal colonization of the biomaterial with other cell types, such as keratocytes and fibroblasts. In at least one embodiment, the microporous biocomposite may be incorporated into an artificial corneal implant or in other avascular mesoplants.

US Patent:

20210244528, Aug 12, 2021

Filed:

Jun 14, 2019

Appl. No.:

17/252017

Inventors:

- newark DE, US
- Baltimore MD, US
Anuraag Singh - Hockessin DE, US
Esen K. Akpek - Baltimore MD, US

International Classification:

A61F 2/14
A61F 2/00
A61L 27/16
A61B 3/16
C08F 214/26
C08F 216/14

Abstract:

Artificial corneas suitable for surgical implantation are provided. Embodiments of artificial corneas include an optical an optical element that includes a body having an anterior side and a posterior side, an annular flange extending about the body, the anterior side including an anterior optical surface and the posterior side of the body including a posterior optical surface, and a tissue integration skirt coupled to the optical element, the tissue integration skirt being configured to promote tissue ingrowth, the tissue integration skirt being coupled to the optical element such that at least a portion of a periphery of the annular flange defined between the anterior and posterior sides of the optical element is covered by the tissue integration skirt. Also described are methods for implanting an artificial cornea of the present disclosure, the methods including providing the artificial cornea, removing a section of corneal tissue from the patient's cornea to form a tissue bed of existing tissue to which the artificial cornea can be affixed, implanting the art the artificial cornea such that the posterior side of the artificial cornea is suspended above the interior of the eye, and mechanically affixing the implanted artificial cornea to the existing corneal tissue of the tissue bed.