Arash Olyie Naghavi

US Patent:

20130177624, Jul 11, 2013

Filed:

May 7, 2010

Appl. No.:

13/319466

Inventors:

David Brian Corry - Houston TX, US
Farrah Kheradmand - Houston TX, US
Preethi Gunaratne - Houston TX, US
Sumanth Polikepahad - Houston TX, US
Arash Olyie Naghavi - Katy TX, US

International Classification:

C12N 15/113
A61K 31/713
A61K 45/06
C12Q 1/68

US Classification:

424450, 506 16, 435375, 514 44 A, 4241311, 435 612, 536 245, 435 613, 506 9

Abstract:

Disclosed are methods for detecting an allergic lung disease that involve assessing the level of one or more microRNAs (miRNAs) in a biological sample, wherein the level of the one or more miRNAs in the biological sample compared to a reference level of the one or more miRNAs is indicative of allergic lung disease. Also disclosed are methods for the treatment or prevention of inflammatory or allergic lung disease that involve administration of a let-7 miRNA inhibitor as set forth herein, as well as biochips and kits that can be applied in the methods of the present invention.